Imbruvica

Last updated on RxList: 11/15/2021
Imbruvica Patient Information Including Side Effects

Brand Names: Imbruvica

Generic Name: ibrutinib

What is ibrutinib (Imbruvica)?

Ibrutinib is used to treat mantle cell lymphoma, marginal zone lymphoma, Waldenstrom's macroglobulinemia, chronic lymphocytic leukemia, and small lymphocytic lymphoma.

Ibrutinib is also used to treat chronic graft-versus-host disease.

Ibrutinib may also be used for purposes not listed in this medication guide.

What are the possible side effects of ibrutinib (Imbruvica)?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using ibrutinib and call your doctor at once if you have:

  • severe or ongoing diarrhea;
  • chest pain, pounding heartbeats or fluttering in your chest, feeling like you might pass out;
  • severe headache, blurred vision, pounding in your neck or ears;
  • pale skin, cold hands and feet;
  • easy bruising or bleeding (nosebleeds, bleeding gums);
  • signs of bleeding inside your body--dizziness, confusion, problems with speech, prolonged headache, black or bloody stools, pink or brown urine, or coughing up blood or vomit that looks like coffee grounds;
  • signs of infection--fever, chills, weakness, mouth sores, cough with mucus, trouble breathing;
  • kidney problems--little or no urinating, swelling in your feet or ankles; or
  • signs of tumor cell breakdown--tiredness, muscle cramps, nausea, vomiting, diarrhea, fast or slow heart rate, tingling in your hands and feet or around your mouth;

Common side effects may include:

  • diarrhea, nausea;
  • fever, cough, trouble breathing;
  • blisters or ulcers in your mouth;
  • feeling tired;
  • bruising, rash; or
  • muscle pain, bone pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about ibrutinib (Imbruvica)?

Ibrutinib can make it easier for you to bleed, even from a minor injury. Seek medical attention if you have bleeding that will not stop.

Bleeding may also happen inside your body. Call your doctor at once if you have signs such as dizziness, confusion, headache, speech problems, black or bloody stools, pink or brown urine, or coughing up blood or vomit that looks like coffee grounds.

Ibrutinib also affects your immune system. You may get infections more easily, even serious or fatal infections. Tell your doctor if you have a fever, chills, cough, mouth sores, or other signs of infection.

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Imbruvica Patient Information including How Should I Take

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What should I discuss with my healthcare provider before taking ibrutinib (Imbruvica)?

You should not use ibrutinib if you are allergic to it.

Tell your doctor if you have ever had:

Using ibrutinib may increase your risk of developing other types of cancer. Ask your doctor about your specific risk.

Both men and women using this medicine should use birth control to prevent pregnancy. Ibrutinib can harm an unborn baby if the mother or father is using this medicine.

Keep using birth control for at least 1 month after your last dose. Tell your doctor right away if a pregnancy occurs while either the mother or the father is using ibrutinib .

Do not breastfeed while using this medicine, and for at least 1 week after your last dose.

How should I take ibrutinib (Imbruvica)?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. Ibrutinib is usually taken until your body no longer responds to the medication.

Take this medicine with a full glass of water, at the same time each day. Drink plenty of liquids while you are taking ibrutinib.

Swallow the tablet or capsule whole and do not crush, chew, break, or open it.

If you need surgery or dental work, tell your surgeon or dentist you currently use this medicine. You may need to stop for a short time.

Call your doctor if you have severe or ongoing diarrhea. You can easily become dehydrated while taking ibrutinib.

Ibrutinib affects your immune system. You may get infections more easily, even serious or fatal infections. You will need frequent medical tests.

Ibrutinib can make it easier for you to bleed, even from a minor injury. Seek medical attention if you have bleeding that will not stop. Bleeding may also happen inside your body, such as in your stomach or intestines, or in your brain.

Store in the original package at room temperature, away from moisture and heat.

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Imbruvica Patient Information including If I Miss a Dose

What happens if I miss a dose (Imbruvica)?

Take the missed dose on the same day you remember it. Take your next dose at the regular time and stay on your once-daily schedule. Do not take 2 doses on the same day.

What happens if I overdose (Imbruvica)?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking ibrutinib (Imbruvica)?

Grapefruit and Seville oranges may interact with ibrutinib and lead to unwanted side effects. Avoid the use of grapefruit products and orange marmalades.

What other drugs will affect ibrutinib (Imbruvica)?

Other drugs may affect ibrutinib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information (Imbruvica)?

Your pharmacist can provide more information about ibrutinib.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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