Imitrex vs. Treximet

Are Imitrex and Treximet the Same Thing?

Imitrex (sumatriptan) and Treximet (sumatriptan and naproxen sodium) are used to treat migraine headaches.

Imitrex is a selective serotonin receptor agonist (also called a triptan) and Treximet is a combination of a triptan and a nonsteroidal anti-inflammatory drug (NSAID).

What Are Possible Side Effects of Imitrex?

Common side effects of Imitrex include:

  • mild headache (not a migraine),
  • pain or chest tightness,
  • pressure or heavy feeling in any part of your body,
  • weakness,
  • feeling hot or cold,
  • dizziness,
  • spinning sensation,
  • drowsiness,
  • nausea,
  • vomiting,
  • drooling,
  • unusual taste in your mouth after using nasal spray,
  • burning/numbness/pain/irritation in your nose or throat after using nasal spray, or
  • flushing (warmth, redness, or tingling under the skin).

What Are Possible Side Effects of Treximet?

Common side effects of Treximet include:

  • dizziness
  • drowsiness
  • flushing (warmth, heat, or tingly feeling)
  • redness in your face
  • feelings of prickling/heat
  • tiredness
  • nausea
  • heartburn
  • constipation
  • upset stomach
  • dry mouth
  • tight muscles
  • weakness
  • mild pressure or heavy feeling in any part of your body

What is Imitrex?

Imitrex (sumatriptan) is a selective serotonin receptor agonist used in oral, intranasal or injectable dosage form to treat migraine headaches. Imitrex is available as a generic drug.

What is Treximet?

Treximet (sumatriptan and naproxen sodium) is a combination of a headache medicine and a nonsteroidal anti-inflammatory drug (NSAID) used to treat migraine headaches. Treximet will only treat a headache that has already begun.


Who suffers more frequently from migraine headaches? See Answer

What Drugs Interact With Imitrex?

Imitrex may interact with sibutramine (Meridia); monoamine oxidase inhibitors (MAOIs) isocarboxazid (Marplan); selective serotonin reuptake inhibitors, fluoxetine (Prozac) and sertraline (Zoloft), serotonin; norepinephrine reuptake inhibitors, venlafaxine (Effexor)) and duloxetine (Cymbalta); and ergot-containing medications, dihydroergotamine (Migranal) and ergotamine (Methergine).

What Drugs Interact With Treximet?

Treximet may interact with blood thinners, lithium, methotrexate, probenecid, diuretics (water pills), steroids, aspirin, other NSAIDs (nonsteroidal anti-inflammatory drugs), ACE inhibitors, beta-blockers, or antidepressants.

How Should Imitrex Be Taken?

The maximum single recommended adult dose of Imitrex Injection for the acute treatment of migraine or cluster headache is 6 mg injected subcutaneously. For the treatment of migraine, if side effects are dose limiting, lower doses (1 mg to 5 mg) of Imitrex may be used.

How Should Treximet Be Taken?

Treximet is a tablet with a fixed dose combination of 85 mg sumatriptan and 500 mg naproxen sodium. The usual dose is one tablet.


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Medical Editor: John P. Cunha, DO, FACOEP


GSK. Imitrex Product Information.

Treximet Product Information.

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