Impeklo Side Effects Center

Last updated on RxList: 5/27/2020
Impeklo Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Is Impeklo?

Impeklo (clobetasol propionate) lotion is a corticosteroid used to relieve inflammatory and itching manifestations of corticosteroid-responsive dermatoses, in patients 18 years of age or older.

What Are Side Effects of Impeklo?

Side effects of Impeklo include:

Dosage for Impeklo

Impeklo lotion should be applied directly onto the affected skin areas in a twice daily (not to exceed 10 actuations/application or 20 actuations/day) dose and rubbed in gently.

Impeklo In Children

Use of Impeklo lotion in pediatric patients is not recommended due to the potential for HPA axis suppression.

Because of higher ratio of skin surface area to body mass, pediatric patients are at a greater risk than adults of HPA axis suppression and Cushing's syndrome when they are treated with topical corticosteroids. They are therefore also at greater risk of glucocorticosteroid insufficiency during and/or after withdrawal of treatment.

What Drugs, Substances, or Supplements Interact with Impeklo?

Impeklo may interact with other medicines.

Tell your doctor all medications and supplements you use.

Impeklo During Pregnancy and Breastfeeding

Tell your doctor if you are pregnant or plan to become pregnant before using Impeklo; there may be a risk to the fetus. Systemically administered corticosteroids appear in human milk and can suppress growth, interfere with endogenous corticosteroid production, or cause other untoward effects. It is unknown if topically applied Impeklo could result in sufficient systemic absorption to produce detectable quantities in human milk. Consult your doctor before breastfeeding.

Additional Information

Our Impeklo (clobetasol propionate) Lotion, for Topical Use Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Impeklo Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • worsening of your skin condition;
  • redness, warmth, swelling, oozing, or severe irritation of any treated skin;
  • blurred vision, tunnel vision, eye pain, or seeing halos around lights;
  • high blood sugar--increased thirst, increased urination, dry mouth, fruity breath odor; or
  • possible signs of absorbing this medicine through your skin--weight gain in your face and shoulders, slow wound healing, skin discoloration, thinning skin, increased body hair, tiredness, mood changes, menstrual changes, sexual changes.

Common side effects may include:

  • burning, itching, swelling, or irritation of treated skin;
  • dry or cracking skin;
  • redness or crusting around your hair follicles;
  • spider veins;
  • stretch marks, thinning skin;
  • rash or hives;
  • acne; or
  • temporary hair loss.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Impeklo (Clobetasol Propionate Lotion)


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Impeklo Professional Information


The following adverse reactions are discussed in greater detail in other sections of the labeling:

  • Effects on the Endocrine System [see WARNINGS AND PRECAUTIONS]
  • Ophthalmic Adverse Reactions [see WARNINGS AND PRECAUTIONS]

Clinical Trials Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice.

In controlled, clinical trials with clobetasol propionate lotion, 0.05%, the following adverse reactions have been reported: burning/stinging, skin dryness, irritation, erythema, folliculitis, pruritus, skin atrophy, and telangiectasia. The pooled incidence of local adverse reactions in trials for psoriasis and atopic dermatitis with clobetasol propionate lotion, 0.05% at 1% or greater was:

Table 1: Adverse Reactions with Incidence ≥ 1% in Clinical Trials

Adverse ReactionIncidence
Skin Atrophy4.2%
Discomfort Skin1.3%
Skin Dry1.0%

Most local adverse events were rated as mild to moderate and they are not affected by age, race or gender.

Systemic absorption of topical corticosteroids has produced hypothalamic-pituitary-adrenal (HPA) axis suppression, manifestations of Cushing's syndrome, hyperglycemia, and glucosuria in some patients.

Postmarketing Experience

Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. The following adverse reactions have been identified during post-approval use of clobetasol propionate lotion, 0.05%.

  • Endocrine Disorders: Cushing's syndrome, adrenal suppression
  • Eye Disorders: cataracts, glaucoma and increased intraocular pressure.
  • Skin: rash, pain of skin, skin exfoliation, skin chapped, scaling, induration/papulation, lichenification.
  • Other: psoriasis (aggravation), plaque elevation, excoriation.

Read the entire FDA prescribing information for Impeklo (Clobetasol Propionate Lotion)

© Impeklo Patient Information is supplied by Cerner Multum, Inc. and Impeklo Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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