Implanon Side Effects Center

Last updated on RxList: 10/28/2022
Implanon Side Effects Center

What Is Implanon?

Implanon (etonogestrel) is a contraceptive used to prevent pregnancy.

What Are Side Effects of Implanon?

Common side effects of Implanon include

Implanon may cause serious side effects including:

  • warmth, redness, swelling, or oozing where the implant was inserted,
  • severe pain or cramping in your pelvic area,
  • sudden numbness or weakness (especially on one side of the body),
  • sudden severe headache,
  • slurred speech,
  • problems with vision or balance,
  • sudden vision loss,
  • stabbing chest pain,
  • feeling short of breath,
  • coughing up blood,
  • pain or warmth in one or both legs,
  • chest pain or pressure,
  • pain spreading to your jaw or shoulder,
  • nausea,
  • sweating,
  • severe headache,
  • blurred vision,
  • pounding in your neck or ears,
  • swelling in your hands, ankles or feet,
  • yellowing of the skin or eyes,
  • breast lump,
  • depression,
  • sleep problems,
  • weakness,
  • tired feeling, and
  • mood changes

Get medical help right away, if you have any of the symptoms listed above.

  • nausea,
  • stomach cramping/bloating/pain,
  • dizziness,
  • headache,
  • mood changes,
  • depression,
  • breast tenderness or pain,
  • acne,
  • hair loss,
  • weight gain,
  • problems with contact lenses,
  • sore throat,
  • flu symptoms,
  • back pain,
  • nervousness,
  • menstrual cramps,
  • changes in menstrual periods,
  • vaginal itching, and
  • vaginal irritation or discharge.

Other side effects of Implanon include

  • pain,
  • bruising,
  • numbness,
  • infection,
  • tingling,
  • minor bleeding, and
  • scarring at the site where the rod is placed.

Seek medical care or call 911 at once if you have the following serious side effects:

  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheadedness, or passing out;
  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

Dosage for Implanon?

The medicine in Implanon is contained in a small plastic rod that is implanted into the skin of your upper arm. The medicine dose is released slowly into the body. The rod can remain in place and provide continuous contraception for up to 3 years.

Implanon may cause serious side effects including:

  • warmth, redness, swelling, or oozing where the implant was inserted,
  • severe pain or cramping in your pelvic area,
  • sudden numbness or weakness (especially on one side of the body),
  • sudden severe headache,
  • slurred speech,
  • problems with vision or balance,
  • sudden vision loss,
  • stabbing chest pain,
  • feeling short of breath,
  • coughing up blood,
  • pain or warmth in one or both legs,
  • chest pain or pressure,
  • pain spreading to your jaw or shoulder,
  • nausea,
  • sweating,
  • severe headache,
  • blurred vision,
  • pounding in your neck or ears,
  • swelling in your hands, ankles or feet,
  • yellowing of the skin or eyes,
  • breast lump,
  • depression,
  • sleep problems,
  • weakness,
  • tired feeling, and
  • mood changes

Get medical help right away, if you have any of the symptoms listed above.

Seek medical care or call 911 at once if you have the following serious side effects:

  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheartedness, or passing out;
  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

What Drugs, Substances, or Supplements Interact with Implanon?

Implanon may interact with phenylbutazone, modafinil, St. John's wort, antibiotics, seizure medicines, barbiturates, and HIV medicines. Tell your doctor all medications you are taking.

Implanon During Pregnancy and Breastfeeding

Implanon should not be used during pregnancy. If you become pregnant or think you may be pregnant, inform your doctor immediately. A certain serious pregnancy problem (ectopic pregnancy) may be more likely if you become pregnant while using this product. Implanon passes into breast milk in small amounts. Consult your doctor before breast-feeding.

Additional Information

Our Implanon Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

QUESTION

Which of the following are methods for contraception? See Answer
Implanon Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • warmth, redness, swelling, or oozing where the implant was inserted;
  • severe pain or cramping in your pelvic area (may be only on one side);
  • signs of a stroke--sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance;
  • signs of a blood clot--sudden vision loss, stabbing chest pain, feeling short of breath, coughing up blood, pain or warmth in one or both legs;
  • heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;
  • increased blood pressure--severe headache, blurred vision, pounding in your neck or ears;
  • swelling in your hands, ankles, or feet;
  • jaundice (yellowing of the skin or eyes);
  • a breast lump; or
  • symptoms of depression--sleep problems, weakness, tired feeling, mood changes.

Common side effects may include:

  • pain where the implant was inserted;
  • changes in your menstrual periods;
  • vaginal itching or discharge;
  • acne, mood changes, weight gain;
  • back pain, menstrual cramps;
  • nausea, stomach pain;
  • breast pain;
  • headache, dizziness; or
  • flu-like symptoms, sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

SLIDESHOW

Choosing Your Birth Control Method See Slideshow
Implanon Professional Information

SIDE EFFECTS

The following adverse reactions reported with the use of hormonal contraception are discussed elsewhere in the labeling:

  • Changes in Menstrual Bleeding Patterns [see WARNINGS AND PRECAUTIONS]
  • Ectopic Pregnancies [see WARNINGS AND PRECAUTIONS]
  • Thrombotic and Other Vascular Events [see WARNINGS AND PRECAUTIONS]
  • Liver Disease [see WARNINGS AND PRECAUTIONS]

Clinical Trials Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.

In clinical trials involving 942 women who were evaluated for safety, change in menstrual bleeding patterns (irregular menses) was the most common adverse reaction causing discontinuation of use of the non-radiopaque etonogestrel implant (IMPLANON) (11.1% of women).

Adverse reactions that resulted in a rate of discontinuation of ≥1% are shown in Table 3.

Table 3: Adverse Reactions Leading to Discontinuation of Treatment in 1% or Moreof Subjects in Clinical Trials of the Non-Radiopaque Etonogestrel Implant (IMPLANON)

Adverse ReactionsAll Studies
N = 942
Bleeding Irregularities*11.1%
Emotional Lability1"2.3%
Weight Increase2.3%
Headache1.6%
Acne1.3%
Depression*1.0%
* Includes “frequent”, “heavy”, “prolonged”, “spotting”, and other patterns of bleeding irregularity.
†Among US subjects (N=330), 6.1% experienced emotional lability that led to discontinuation.
‡Among US subjects (N=330), 2.4% experienced depression that led to discontinuation.

Other adverse reactions that were reported by at least 5% of subjects in the non-radiopaque etonogestrel implant clinical trials are listed in Table 4.

Table 4: Common Adverse Reactions Reported by ≥5% of Subjects in Clinical Trials With the Non-Radiopaque Etonogestrel Implant (IMPLANON)

Adverse ReactionsAll Studies
N = 942
Headache24.9%
Vaginitis14.5%
Weight increase13.7%
Acne13.5%
Breast pain12.8%
Abdominal pain10.9%
Pharyngitis10.5%
Leukorrhea9.6%
Influenza-like symptoms7.6%
Dizziness7.2%
Dysmenorrhea7.2%
Back pain6.8%
Emotional lability6.5%
Nausea6.4%
Pain5.6%
Nervousness5.6%
Depression5.5%
Hypersensitivity5.4%
Insertion site pain5.2%

In a clinical trial of NEXPLANON, in which investigators were asked to examine the implant site after insertion, implant site reactions were reported in 8.6% of women. Erythema was the most frequent implant site complication, reported during and/or shortly after insertion, occurring in 3.3% of subjects. Additionally, hematoma (3.0%), bruising (2.0%), pain (1.0%), and swelling (0.7%) were reported.

Postmarketing Experience

The following additional adverse reactions have been identified during post-approval use of IMPLANON and NEXPLANON. Because these reactions are reported voluntarily from a population of uncertain size, it is not possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

Gastrointestinal disorders: constipation, diarrhea, flatulence, vomiting.

General disorders and administration site conditions: edema, fatigue, implant site reaction, pyrexia.

Immune system disorders: anaphylactic reactions.

Infections and infestations: rhinitis, urinary tract infection.

Investigations: clinically relevant rise in blood pressure, weight decreased.

Metabolism and nutrition disorders: increased appetite.

Musculoskeletal and connective tissue disorders: arthralgia, musculoskeletal pain, myalgia.

Nervous system disorders: convulsions, migraine, somnolence.

Pregnancy, puerperium and perinatal conditions: ectopic pregnancy.

Psychiatric disorders: anxiety, insomnia, libido decreased.

Renal and urinary disorders: dysuria.

Reproductive system and breast disorders: breast discharge, breast enlargement, ovarian cyst, pruritus genital, vulvovaginal discomfort.

Skin and subcutaneous tissue disorders: angioedema, aggravation of angioedema and/or aggravation of hereditary angioedema, alopecia, chloasma, hypertrichosis, pruritus, rash, seborrhea, urticaria.

Vascular disorders: hot flush.

Complications related to insertion or removal of the etonogestrel implants reported include: bruising, slight local irritation, pain or itching, fibrosis at the implant site, paresthesia or paresthesialike events, scarring and abscess. Expulsion or migration of the implant has been reported, including to the chest wall. In some cases, implants have been found within the vasculature, including the pulmonary artery. Some cases of implants found within the pulmonary artery reported chest pain and/or dyspnea; others have been reported as asymptomatic [see WARNINGS AND PRECAUTIONS]. Surgical intervention might be necessary when removing the implant.

Read the entire FDA prescribing information for Implanon (Etonogestrel Implant)

© Implanon Patient Information is supplied by Cerner Multum, Inc. and Implanon Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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