Imuran vs. Azulfidine

Are Imuran and Azulfidine the Same Thing?

Imuran (azathioprine) and Azulfidine EN-tabs (sulfasalazine delayed release tablets) are used to treat symptoms of rheumatoid arthritis.

Imuran is also used to prevent the body from rejecting a transplanted kidney.

Azulfidine EN-tabs is also used to treat moderate to severe ulcerative colitis.

Imuran and Azulfidine belong to different drug classes. Imuran is an immunosuppressive antimetabolite and Azulfidine is an anti-inflammatory agent and immunomodulatory agent.

Side effects of Imuran and Azulfidine that are similar include upset stomach, nausea, vomiting, diarrhea, loss of appetite, or skin rash.

Side effects of Imuran that are different from Azulfidine include hair loss.

Side effects of Azulfidine that are different from Imuran include headache, ringing in your ears, dizziness, spinning sensation, unusual tiredness, white patches or sores inside your mouth or on your lips, sleep problems (insomnia), or itching. Azulfidine may also cause temporary male infertility.

Imuran may interact with allopurinol, mercaptopurine, methotrexate, blood thinners, cyclosporine, olsalazine, sulfasalazine, sulfamethoxasole, trimethoprim, or ACE inhibitors.

Azulfidine may interact with digoxin, folic acid, or vitamin or mineral supplements that contain folic acid.

What Are Possible Side Effects of Imuran?

Common side effects of Imuran include:

  • upset stomach,
  • nausea,
  • vomiting,
  • diarrhea,
  • loss of appetite,
  • hair loss, or
  • skin rash.

Tell your doctor if you experience unlikely but serious side effects of Imuran including:

  • muscle loss,
  • hair loss,
  • cold/numbness in the fingers,
  • mouth sores,
  • difficult/painful swallowing, or
  • greasy stools.

What Are Possible Side Effects of Azulfidine?

Common side effects of Azulfidine include:

  • stomach upset,
  • nausea,
  • vomiting,
  • loss of appetite,
  • diarrhea,
  • headache,
  • ringing in your ears,
  • dizziness,
  • spinning sensation,
  • unusual tiredness,
  • white patches or sores inside your mouth or on your lips,
  • sleep problems (insomnia), or
  • itching or skin rash.

Azulfidine may cause temporary male infertility. This effect is reversible when Azulfidine is stopped. Tell your doctor if you have serious side effects of Azulfidine including:

What Is Imuran?

Imuran (azathioprine) is an immunosuppressive antimetabolite used to prevent the body from rejecting a transplanted kidney. Imuran is also used to treat symptoms of rheumatoid arthritis. Imuran is available in generic form.

What Is Azulfidine?

Azulfidine EN-tabs (sulfasalazine delayed release tablets) is an anti-inflammatory agent and immunomodulatory agent used to treat moderate to severe ulcerative colitis. Azulfidine is also used to treat rheumatoid arthritis in children and adults who have received other arthritis medications without successful treatment of symptoms. Azulfidine is available in generic form.

SLIDESHOW

What Is Rheumatoid Arthritis (RA)? Symptoms, Treatment, Diagnosis See Slideshow

What Drugs Interact With Imuran?

Imuran may interact with other medicines that weaken the immune system.

Imuran may interact with allopurinol, methotrexate, blood thinners, olsalazine, sulfasalazine, sulfamethoxasole, trimethoprim, or ACE inhibitors.

What Drugs Interact With Azulfidine?

Azulfidine EN-tabs may interact with digoxin, folic acid, or vitamin or mineral supplements that contain folic acid. There may be other drugs that can interact with Azulfidine. Tell your doctor about all the prescription and over-the-counter medications and supplements you use. During pregnancy, Azulfidine EN-tabs should be used only when prescribed. Caution is advised if this medication is used near the expected delivery date because similar drugs may cause harm to a newborn. This medication may lower folic acid levels, increasing the risk of spinal cord defects. Consult your doctor about taking enough folic acid. This drug passes into breast milk and could have undesirable effects on a nursing infant. Consult your doctor before breastfeeding.

How Should Imuran Be Taken?

The dose of Imuran to prevent transplant rejection and minimize toxicity varies. The initial dose is usually 3 to 5 mg/kg daily, beginning at the time of transplant. It is usually given as a single daily dose on the day of, and in some cases 1 to 3 days before, transplantation. Maintenance levels of 1 to 3 mg/kg daily are usually possible. For rheumatoid arthritis, the initial dose is approx. 1.0 mg/kg (50 to 100 mg) given as a single dose or twice-daily. Maximum dose is 2.5 mg/kg per day.

How Should Azulfidine Be Taken?

Adult doses of Azulfidine range from 1000 mg to 4000 mg daily, taken 2 to 4 times daily depending on the condition being treated. Pediatric doses are determined by weight.

QUESTION

The term arthritis refers to stiffness in the joints. See Answer
Disclaimer

All drug information provided on RxList.com is sourced directly from drug monographs published by the U.S. Food and Drug Administration (FDA).

Any drug information published on RxList.com regarding general drug information, drug side effects, drug usage, dosage, and more are sourced from the original drug documentation found in its FDA drug monograph.

Drug information found in the drug comparisons published on RxList.com is primarily sourced from the FDA drug information. The drug comparison information found in this article does not contain any data from clinical trials with human participants or animals performed by any of the drug manufacturers comparing the drugs.

The drug comparisons information provided does not cover every potential use, warning, drug interaction, side effect, or adverse or allergic reaction. RxList.com assumes no responsibility for any healthcare administered to a person based on the information found on this site.

As drug information can and will change at any time, RxList.com makes every effort to update its drug information. Due to the time-sensitive nature of drug information, RxList.com makes no guarantees that the information provided is the most current.

Any missing drug warnings or information does not in any way guarantee the safety, effectiveness, or the lack of adverse effects of any drug. The drug information provided is intended for reference only and should not be used as a substitute for medical advice.

If you have specific questions regarding a drug’s safety, side effects, usage, warnings, etc., you should contact your doctor or pharmacist, or refer to the individual drug monograph details found on the FDA.gov or RxList.com websites for more information.

You may also report negative side effects of prescription drugs to the FDA by visiting the FDA MedWatch website or calling 1-800-FDA-1088.

References
Dailymed. Imuran Product Information.
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=aaa6c540-4c84-48a0-939c-cd423134fa2a&audience=consumer
Dailymed. Azulfidine Product Information.
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ddbe69f3-bd55-45f3-a64f-f60226c744c4&audience=consumer

Health Solutions From Our Sponsors