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Inderal XL

Last reviewed on RxList: 1/13/2017
Inderal XL Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 12/22/2015

Inderal XL (propranolol hydrochloride) extended-release capsules is a beta adrenergic blocker indicated for the treatment of high blood pressure (hypertension), to lower blood pressure. Common side effects of Inderal XL include fatigue, dizziness, and constipation.

The starting dose of Inderal XL is 80 mg, adjusted up to 120 mg if needed. Inderal XL may interact with warfarin, propafenone, bupropion, fluoxetine, paroxetine, quinidine, ciprofloxacin, enoxamine, fluvoxamine, fluconazole, fluvoxamine, ticlopidine, phenytoin, montelukast, smoking, rifampin, cholestyramine or colestipol, clonidine, alpha-blockers, dobutamine, MAO inhibitors or tricyclic antidepressants, and nonsteroidal anti-inflammatory drugs (NSAIDS). Tell your doctor all medications and supplements you use. During pregnancy, Inderal XL should be used only if prescribed. It is unknown if it could affect a fetus. Inderal XL passes into breast milk. Consult your doctor before breastfeeding.

Our Inderal XL (propranolol hydrochloride) extended-release capsules Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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Salt and sodium are the same. See Answer
Inderal XL Professional Information

SIDE EFFECTS

Clinical Trials Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.

Adverse reactions occurring at a rate of ≥ 3%, excluding those reported more commonly in placebo, encountered in the INDERAL XL placebo-controlled hypertension trials and plausibly related to treatment are shown in Table 1.

Table 1: Treatment-Emergent Adverse Reactions Reported In ≥ 3% of Subjects

Body System Placebo
(N=88)
INDERAL XL
80 mg
(N=89)
120 mg
(N=85)
Fatigue 3 (3%) 4 (5%) 6 (7%)
Dizziness (except vertigo) 2 (2%) 6 (7%) 3 (4%)
Constipation 0 3 (3%) 1(1%)

Postmarketing Experience

In addition to adverse reactions reported from clinical trials, the following reactions have been identified during post-marketing use of INDERAL XL. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

The following adverse reactions were observed and have been reported with use of formulations of sustained- or immediate-release propranolol.

Allergic: Hypersensitivity reactions, including anaphylactic/anaphylactoid reactions; pharyngitis and agranulocytosis; erythematous rash, fever combined with aching and sore throat, laryngospasm, and respiratory distress.

Autoimmune: Systemic lupus erythematosus (SLE).

Cardiovascular: exacerbation of peripheral arterial disease, arterial insufficiency, usually of the Raynaud type.

Central Nervous System: Light-headedness, mental depression, insomnia, lassitude, weakness, fatigue, visual disturbances, hallucinations, vivid dreams, short-term memory loss, emotional lability, slightly clouded sensorium, paresthesia of hands.

Gastrointestinal: Nausea, vomiting, epigastric distress, abdominal cramping, diarrhea, mesenteric arterial thrombosis, ischemic colitis.

Genitourinary: Male impotence; Peyronie's disease.

Hematologic: Agranulocytosis, nonthrombocytopenic purpura, thrombocytopenic purpura.

Musculoskeletal: Myopathy, myotonia.

Skin and mucous membranes: Stevens-Johnson syndrome, toxic epidermal necrolysis, dry eyes, exfoliative dermatitis, erythema multiforme, urticaria, alopecia, SLE-like reactions, and psoriasisiform rashes.

Read the entire FDA prescribing information for Inderal XL (Inderal XL Propranolol Hydrochloride Capsules)

SLIDESHOW

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Related Resources for Inderal XL

© Inderal XL Patient Information is supplied by Cerner Multum, Inc. and Inderal XL Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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