Last updated on RxList: 5/3/2021
INFeD Side Effects Center

What Is INFeD?

INFeD (iron dextran) Injection is a form of the mineral iron used to treat iron deficiencies and iron deficiency anemia.

What Are Side Effects of INFeD?

Common side effects of INFeD include:

  • flushing,
  • tingling of the hands/feet,
  • shivering, or
  • dizziness,
  • injection site reactions (tenderness, irritation, soreness, pain, swelling, redness, or brown discoloration),
  • nausea,
  • vomiting,
  • diarrhea,
  • fever,
  • sweating,
  • chills,
  • muscle or joint pain or aches,
  • metallic taste in the mouth, or
  • headache.

Some people may experience a delayed reaction 1-2 days after their treatment with INFeD. Tell your doctor if any of these side effects persist or worsen more than 4 to 7 days after your treatment with INFeD:

  • back/joint/muscle aches,
  • chills,
  • moderate to high fever,
  • headache,
  • nausea, or
  • vomiting.

Tell your doctor if you have serious side effects of INFeD including:

  • abdominal pain,
  • fast/slow/irregular heartbeat,
  • severe headache, or
  • blurred vision.

Dosage for INFeD

Dose of INFed is calculated based on the patient's weight and laboratory test indications.

What Drugs, Substances, or Supplements Interact with INFeD?

Other drugs may interact with INFed. Tell your doctor all prescription and over-the-counter medicines and supplements you use.

INFeD During Pregnancy or Breastfeeding

During pregnancy, INFeD should be used only when prescribed. This medication passes into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breastfeeding.

Additional Information

Our INFeD (iron dextran) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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INFeD Consumer Information

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Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Iron dextran can cause severe and sometimes fatal allergic reactions or severely low blood pressure. Call your doctor or seek medical help right away if you feel light-headed or if you suddenly have trouble breathing.

Also all your doctor at once if you have:

  • fast or slow heartbeats. chest pain, wheezing, trouble breathing;
  • a light-headed feeling, like you might pass out;
  • flushing (warmth, redness, or tingly feeling);
  • blue-colored lips or fingernails;
  • red or pink urine;
  • weak or shallow breathing (breathing may stop);
  • seizure (convulsions);
  • swelling, warmth, redness, or itching where the medicine was injected; or
  • delayed effect (1-2 days after injection)--fever, chills, dizziness, headache, general ill feeling, nausea and vomiting, joint or muscle pain, back pain.

Common side effects may include:

  • mild itching or rash;
  • body aches, numbness or tingly feeling;
  • nausea, vomiting, stomach pain, diarrhea;
  • mild dizziness or weakness, low fever; or
  • brown discoloration of your skin.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for INFeD (Iron Dextran)

INFeD Professional Information


The following clinically significant adverse reactions are described elsewhere in the labeling:

  • Hypersensitivity Reactions [see WARNINGS AND PRECAUTIONS]
  • Delayed Reactions [see WARNINGS AND PRECAUTIONS]
  • Increased Risk of Toxicity in Patients with Underlying Conditions [see WARNINGS AND PRECAUTIONS]
  • Iron Overload [see WARNINGS AND PRECAUTIONS]
  • Fetal bradycardia [see Use In Specific Populations]

The following adverse reactions associated with the use of INFeD were identified in clinical studies or postmarketing reports. Because some of these reactions were reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

Blood and lymphatic system disorders: Leukocytosis, lymphadenopathy.

Cardiac disorders: Cardiac arrest, tachycardia, bradycardia, arrhythmias.

Gastrointestinal disorders: Abdominal pain, nausea, vomiting, diarrhea.

General disorders and administration site conditions: chest pain, chest tightness, weakness, malaise, febrile episodes, chills, shivering, sterile abscess, atrophy/fibrosis (intramuscular injection site), brown skin and/or underlying tissue discoloration (staining), soreness or pain at or near intramuscular injection sites, swelling, inflammation.

Musculoskeletal and connective tissue disorders: Arthralgia, arthritis (may represent reactivation in patients with quiescent rheumatoid arthritis - [see WARNINGS AND PRECAUTIONS], myalgia, backache.

Nervous system disorders: Convulsions, seizures, syncope, headache, unresponsiveness, paresthesia, dizziness, numbness, unconsciousness, altered taste.

Psychiatric disorders: Disorientation

Respiratory, thoracic and mediastinal disorders: Respiratory arrest, dyspnea, bronchospasm, wheezing.

Renal and urinary disorders: Hematuria.

Skin and subcutaneous disorders: Urticaria, pruritus, purpura, rash, sweating.

Vascular disorders: Cyanosis, shock, hypertension, hypotension, flushing (flushing and hypotension may occur from too rapid injections by the intravenous route), local phlebitis at or near intravenous injection site.


Drug/Laboratory Test Interactions

Drug interactions involving INFeD have not been studied.

Concomitant use of angiotensin-converting enzyme inhibitor drugs may increase the risk for anaphylactic-type reactions to an iron dextran product.

Large doses of iron dextran (5 mL or more) have been reported to give a brown color to serum from a blood sample drawn 4 hours after administration.

INFeD may cause falsely elevated values of serum bilirubin and falsely decreased values of serum calcium.

Serum iron determinations (especially by colorimetric assays) may not be meaningful for 3 weeks following the administration of INFeD.

Examination of the bone marrow for iron stores may not be meaningful for prolonged periods following iron dextran therapy because residual iron dextran may remain in the reticuloendothelial cells.

Bone scans involving 99m Tc-diphosphonate have been reported to show a dense, crescentic area of activity in the buttocks, following the contour of the iliac crest, 1 to 6 days after intramuscular injections of INFeD.

Bone scans with 99m Tc-labeled bone seeking agents, in the presence of high serum ferritin levels or following INFeD infusions, have been reported to show reduction of bony uptake, marked renal activity, and excessive blood pool and soft tissue accumulation.

Read the entire FDA prescribing information for INFeD (Iron Dextran)

© INFeD Patient Information is supplied by Cerner Multum, Inc. and INFeD Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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