Inspra vs. Aldactone

Are Inspra and Aldactone the Same Thing?

Inspra (eplerenone) and Aldactone (spironolactone) are aldosterone receptor antagonists used to treat high blood pressure (hypertension).

Aldactone is also used to reduce fluid retention (edema) caused by heart, liver or kidney problems, and certain patients with hyperaldosteronism.

Inspra is also used to treat congestive heart failure after a heart attack.

What Are Possible Side Effects of Inspra?

Common side effects of Inspra include:

Tell your doctor if you have rare but serious side effects of Inspra including:

What Are Possible Side Effects of Aldactone?

Common side effects of Aldactone include:

  • skin rash,
  • headache,
  • dizziness,
  • nausea,
  • vomiting,
  • gas, and
  • stomach pain.

Tell your doctor if you have serious side effects of Aldactone including irregular heart rate, muscle pain or weakness, urinating less than usual, shallow breathing, tremors, confusion, or a severe skin reaction, hyperkalemia (high levels of potassium in the blood), and numbness.

What Is Inspra?

Inspra (eplerenone) is an aldosterone receptor blocker, which is an antihypertensive, used to treat congestive heart failure after a heart attack, and is also used to treat high blood pressure (hypertension). Inspra is available in generic form.

What Is Aldactone?

Aldactone (spironolactone) is an aldosterone receptor antagonist that causes the kidneys to remove water and sodium from the body, with reduced losses of potassium. Aldactone is used to reduce edema caused by heart, liver or kidney problems, high blood pressure (hypertension), and certain patients with hyperaldosteronism.


Salt and sodium are the same. See Answer

What Drugs Interact With Inspra?

Inspra may interact with lithium, other blood pressure medications, antibiotics, antifungals, ACE inhibitors, NSAIDs (non-steroidal anti-inflammatory drugs), HIV/AIDS medicines, or antidepressants. Tell your doctor all medications you are taking.

What Drugs Interact With Aldactone?

Aldactone may interact with lithium or steroids.

Aldactone may also interact with other medicines that make you sleepy (such as cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety), digoxin, ACE inhibitors, or nonsteroidal anti-inflammatory drugs (NSAIDs).

How Should Inspra Be Taken?

Treatment with Inspra is initiated at 25 mg once daily and adjusted to the recommended dose of 50 mg once daily, preferably within 4 weeks as tolerated by the patient.

How Should Aldactone Be Taken?

Aldactone is available in 25, 50 and 100 mg tablets. Because of tumor formation in experimental animals, use in pregnancy should be avoided unless the benefits outweigh the potential risks to the fetus; women who are breastfeeding are advised not to use Aldactone. In addition, the drug should not be used to decrease the normal edema of pregnancy. An active metabolite of Aldactone appears in breast milk. Breastfeeding while using Aldactone is not recommended. If use of Aldactone is deemed essential, an alternative method of infant feeding should be used.


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Pfizer. Inspra Product Information.
Pfizer. Aldactone Product Information.

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