How Do Insulinlike Growth Factor Inhibitors Work?

Reviewed on 8/30/2021

HOW DO INSULIN-LIKE GROWTH FACTOR INHIBITORS WORK?

Insulin-like growth factor (IGF) inhibitor drugs are used to treat thyroid eye disease. Thyroid eye disease (also known as Graves’ eye disease) is an autoimmune condition where immune cells attack the thyroid gland which in turn secretes an excess amount of thyroid hormone. An increase in thyroid hormone levels leads to increased heartbeats, sweating, high blood pressure, irritability, weight loss, heat intolerance, fatigue, and loss of hair.

In thyroid eye disease, the tissues around the eye are attacked by the immune cells that attack the thyroid gland and cause inflammation and swelling, leading to:

  • Redness and pain
  • Puffiness around the eyes
  • Bulging of the eyes
  • Dry eye and irritation, occurring when the eyelids cannot close completely over bulging eyes
  • The eye is pushed forward in its socket, causing a “staring” appearance
  • Restriction of the eye’s normal movements, resulting in double vision

Teprotumumab is an IGF inhibitor that binds to IGF type 1 receptor and blocks its activation and signaling. However, the exact mechanism of action is unclear.

HOW ARE INSULIN-LIKE GROWTH FACTOR INHIBITORS USED?

IGF inhibitors are given as intravenous injections to treat thyroid eye disease.

WHAT ARE SIDE EFFECTS OF INSULIN-LIKE GROWTH FACTOR INHIBITORS?

Side effects of IGF inhibitors may include:

The information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

WHAT ARE NAMES OF INSULIN-LIKE GROWTH FACTOR INHIBITORS?

Generic and brand names of IGF inhibitors include:

  • Tepezza
  • Teprotumumab
  • Teprotumumab-trbw

SLIDESHOW

Hyperthyroidism Symptoms and Treatment See Slideshow
References
https://reference.medscape.com/drugs/insulinlike-growth-factor-inhibitors

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888655/

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