Medical Editor: John P. Cunha, DO, FACOEP
Intralipid 20% (20% I.V. Fat Emulsion) is made of 20% soybean oil used to provide calories to patients who are getting their nutrition through an injection into the vein. Intralipid 20% is also used to provide essential fatty acids to people who do not have enough of it, and it helps to prevent or reverse the signs of fatty acid deficiency (e.g., scaly skin, poor growth, poor wound healing). Intralipid 20% is available in generic form. Common side effects of Intralipid 20% include:
- vomiting, or
Tell your doctor if you experience unlikely but serious side effects of Intralipid 20% including:
signs of infection (fever, persistent
sore throat), injection site reactions (pain, swelling, redness),
pain/swelling/redness of arms/legs, bluish skin, sudden weight gain, shortness
of breath, back or chest pain, mental/mood changes, bone pain, muscle weakness,
yellowing of skin and eyes (jaundice), dark urine, easy bruising or bleeding,
severe stomach or abdominal pain, or trouble breathing.
The initial rate of infusion of Intralipid 20% in adults should be 0.5 ml/minute for the first 15 to 30 minutes of infusion. If no untoward reactions occur, the infusion rate can be increased to 1 ml/minute. If there are no adverse reactions, the dose can be increased the following day. The daily dosage should not exceed 2.5 g of fat/kg of body weight (12.5 ml of Intralipid 20% per kg). Intralipid 20% may interact with other drugs. Tell your doctor all medications and supplements you use. During pregnancy, Intralipid 20% should be used only when prescribed. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.Our Intralipid 20% (20% I.V. Fat Emulsion) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
THE ADVERSE REACTIONS OBSERVED CAN BE SEPARATED INTO TWO CLASSES:
- THOSE MORE FREQUENTLY ENCOUNTERED ARE DUE: EITHER TO CONTAMINATION OF THE INTRAVENOUS CATHETER AND RESULT IN SEPSIS, OR TO VEIN IRRITATION BY CONCURRENTLY INFUSED HYPERTONIC SOLUTIONS AND MAY RESULT IN THROMBOPHLEBITIS. THESE ADVERSE REACTIONS ARE INSEPARABLE FROM THE HYPERALIMENTATION PROCEDURE WITH OR WITHOUT INTRALIPID® 20% (A 20% I.V. FAT EMULSION).
- LESS FREQUENT REACTIONS MORE DIRECTLY RELATED TO INTRALIPID® 20% (20% i.v. fat emulsion) ARE: A) IMMEDIATE OR EARLY ADVERSE REACTIONS, EACH OF WHICH HAS BEEN REPORTED TO OCCUR IN CLINICAL TRIALS, IN AN INCIDENCE OF LESS THAN 1%; DYSPNEA, CYANOSIS, ALLERGIC REACTIONS, HYPERLIPEMIA, HYPERCOAGULABILITY, NAUSEA, VOMITING, HEADACHE, FLUSHING, INCREASE IN TEMPERATURE, SWEATING, SLEEPINESS, PAIN IN THE CHEST AND BACK, SLIGHT PRESSURE OVER THE EYES, DIZZINESS, AND IRRITATION AT THE SITE OF INFUSION, AND, RARELY, THROMBOCYTOPENIA IN NEONATES; B) DELAYED ADVERSE REACTIONS SUCH AS HEPATOMEGALY, JAUNDICE DUE TO CENTRAL LOBULAR CHOLESTASIS, SPLENOMEGALY, THROMBOCYTOPENIA, LEUKOPENIA, TRANSIENT INCREASES IN LIVER FUNCTION TESTS, AND OVERLOADING SYNDROME (FOCAL SEIZURES, FEVER, LEUKOCYTOSIS, HEPATOMEGALY. SPLENOMEGALY AND SHOCK).
THE DEPOSITION OF A BROWN PIGMENTATION IN THE RETICULOEN-DOTHELIAL SYSTEM, THE SO CALLED "INTRAVENOUS FAT PIGMENT," HAS BEEN REPORTED IN PATIENTS INFUSED WITH INTRALIPID® 20% (20% i.v. fat emulsion) . THE CAUSES AND SIGNIFICANCE OF THIS PHENOMENON ARE UNKNOWN.
Read the entire FDA prescribing information for Intralipid 20 (20% I.V. Fat Emulsion)
© Intralipid 20 Patient Information is supplied by Cerner Multum, Inc. and Intralipid 20 Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.
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