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Intuniv vs. Vyvanse

Are Intuniv and Vyvanse the Same Thing?

Intuniv (guanfacine) and Vyvanse (lisdexamfetamine dimesylate) are used to treat attention deficit hyperactivity disorder (ADHD).

Intuniv is also used to treat high blood pressure (hypertension) and is often given together with other blood pressure medications.

Unlike other drugs used to treat ADHD, Intuniv is not a stimulant.

Vyvanse is also used to treat moderate to severe binge eating disorder.

Intuniv and Vyvanse belong to different drug classes. Intuniv is an alpha-2 adrenergic agonist and Vyvanse is a central nervous system stimulant.

Side effects of Intuniv and Vyvanse that are similar include dizziness, dry mouth, nausea, headache, stomach pain, irritability, or constipation.

Side effects of Intuniv that are different from Vyvanse include drowsiness, tiredness, or weight gain.

Side effects of Vyvanse that are different from Intuniv include anxiety, decreased appetite, weight loss, diarrhea, sleep problems (insomnia), vomiting, increased heart rate, jittery feeling, mild skin rash, unpleasant taste in your mouth, nervousness, sweating, and restlessness.

Both Intuniv and Vyvanse may interact with seizure medications.

Intuniv may also interact with azole antifungals, rifamycins, antihistamines, medicine for sleep or anxiety, muscle relaxants, narcotics, psychiatric medicines, or cough-and-cold and other over-the-counter products that may contain drowsiness-causing ingredients.

Vyvanse may also interact with ammonium chloride, ascorbic acid (vitamin C), K-Phos, blood pressure medications, diuretics (water pills), antihistamines, chlorpromazine, lithium, methenamine, phenobarbital, pain medication, or antidepressants.

What Are Possible Side Effects of Intuniv?

Common side effects of Intuniv include:

  • drowsiness,
  • dizziness,
  • dry mouth,
  • constipation,
  • tiredness,
  • nausea,
  • headache,
  • stomach pain,
  • weight gain, or
  • irritability.

Tell your doctor if you have serious side effects of Intuniv including:

  • severe dizziness,
  • slow heartbeat,
  • fainting, or
  • mental/mood changes (such as depression, hallucinations, or thoughts of suicide).

What Are Possible Side Effects of Vyvanse?

Common side effects of Vyvanse include:

  • slowing of growth (height and weight) in children

The most common side effects of Vyvanse in ADHD include:

  • anxiety
  • decreased appetite
  • diarrhea
  • dizziness
  • dry mouth
  • irritability
  • loss of appetite
  • nausea
  • trouble sleeping
  • upper stomach pain
  • vomiting
  • weight loss

The most common side effects of Vyvanse in BED include:

  • dry mouth
  • trouble sleeping
  • decreased appetite
  • increased heart rate
  • constipation
  • feeling jittery
  • anxiety

Talk to your doctor if you have any side effects that bother you or do not go away.

These are not all the possible side effects of Vyvanse. For more information ask your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Intuniv?

Intuniv (guanfacine) is an alpha-2 adrenergic agonist used to treat attention deficit hyperactivity disorder (ADHD) in patients older than 6 years of age, as part of a total treatment plan including psychological, educational, and social measures. Unlike other drugs used to treat ADHD, Intuniv is not a stimulant. Intuniv is also used to treat high blood pressure (hypertension) and is often given together with other blood pressure medications.

What Is Vyvanse?

Vyvanse is a central nervous system stimulant prescription medicine used to treat:

  • Attention-Deficit/Hyperactivity Disorder (ADHD). Vyvanse may help increase attention and decrease impulsiveness and hyperactivity in patients with ADHD
  • Binge Eating Disorder (BED). Vyvanse may help reduce the number of binge eating days in patients with BED

Vyvanse is not for weight loss. It is not known if Vyvanse is safe and effective for the treatment of obesity.

It is not known if Vyvanse is safe and effective in children with ADHD under 6 years of age or in patients with BED under 18 years of age.

Do not take Vyvanse if you:

  • are taking or have taken within the past 14 days an anti-depression medicine called a monoamine oxidase inhibitor or MAOI
  • are sensitive to, allergic to, or had a reaction to other stimulant medicines

Before you take Vyvanse, tell your doctor if you have or if there is a family history of:

  • heart problems, heart defects, high blood pressure
  • mental problems including psychosis, mania, bipolar illness, or depression
  • circulation problems in fingers and toes

Tell your doctor if:

  • You have any kidney problems. Your doctor may lower your dose.
  • You are pregnant or plan to become pregnant. It is not known if Vyvanse may harm your unborn baby
  • You are breastfeeding or plan to breastfeed. Vyvanse can pass into your milk. Do not breastfeed while taking Vyvanse. Talk to your doctor about the best way to feed your baby if you take Vyvanse.


ADHD Symptoms in Children See Slideshow

What Drugs Interact With Intuniv?

Intuniv may interact with valproic acid, azole antifungals, rifamycins, antihistamines, anti-seizure drugs, medicine for sleep or anxiety, muscle relaxants, narcotic pain relievers, psychiatric medicines, or cough-and-cold and other over-the-counter products that may contain drowsiness-causing ingredients. During pregnancy, Intuniv should be used only when prescribed.

What Drugs Interact With Vyvanse?

Tell your doctor about all of the medicines that you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Vyvanse can affect the way other medicines work, and other medicines may affect how Vyvanse works. Using Vyvanse with other medicines can cause serious side effects.

Especially tell your doctor if you take anti-depression medicines including MAOIs.

Ask your doctor or pharmacist for a list of these medicines if you are not sure.

Know the medicines that you take. Keep a list of them to show your doctor and pharmacist when you get a new medicine.

Do not start any new medicine while taking Vyvanse without talking to your doctor first.

Do not drive, operate machinery, or do other dangerous activities until you know how Vyvanse affects you.

How Should Intuniv Be Taken?

Intuniv is an extended-release tablet dosed once daily. Starting dose is 1 mg/day, and the maintenance dose is in the range of 1-4 mg once daily, depending on clinical response and tolerability.

How Should Vyvanse Be Taken?

  • Take Vyvanse exactly as your doctor tells you to take it.
  • Your doctor may change your dose until it is right for you.
  • Take Vyvanse 1 time each day in the morning.
  • Vyvanse can be taken with or without food.
  • Vyvanse capsules may be swallowed whole.
  • If you have trouble swallowing capsules, open your Vyvanse capsule and pour all the powder into yogurt, water, or orange juice.
    • Use all of the Vyvanse powder from the capsule so you get all of the medicine.
    • Using a spoon, break apart any powder that is stuck together. Stir the Vyvanse powder and yogurt, water or orange juice until they are completely mixed together.
    • Eat all the yogurt or drink all the water or orange juice right away after it has been mixed with Vyvanse. Do not store the yogurt, water, or orange juice after it has been mixed with Vyvanse. It is normal to see a film y coating on the inside of your glass or container after you eat or drink all the Vyvanse.
  • Your doctor may sometimes stop Vyvanse treatment for a while to check your ADHD or your BED symptoms.
  • Your doctor may do regular checks of your heart, and blood pressure while taking Vyvanse.
  • Children should have their height and weight checked often while taking Vyvanse. Vyvanse treatment may be stopped if a problem.
  • If you take too much Vyvanse, call your doctor or poison control center (1-800-222-1222) right away, or get to the nearest hospital emergency room.


The abbreviated term ADHD denotes the condition commonly known as: See Answer

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Shire Pharmaceuticals. Intuniv Product Information.

Shire Pharmaceuticals. Vyvanse Drug Information.

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