Iopidine Eye

Last updated on RxList: 3/12/2018
Iopidine Eye Side Effects Center

Last reviewed on RxList 3/12/2018

Iopidine 0.5% (apraclonidine) is an alpha-adrenergic agonist, which decreases the amount of fluid in the eye, decreasing pressure in the eye, used to treat or prevent high pressure inside the eye caused by certain types of eye surgery or procedures. Iopidine 0.5% is available in generic form. Common side effects of Iopidine 0.5% include:

  • eye discomfort/redness/burning/dryness,
  • blurred or dimmed vision,
  • feeling like something is in your eye,
  • dry mouth,
  • dry or stuffy nose,
  • dizziness,
  • drowsiness,
  • stomach pain or upset,
  • nausea,
  • diarrhea,
  • headache,
  • sleep problems (insomnia), or
  • unusual tiredness.

Eye itching or watering, or eyelid swelling or puffiness may be symptoms of an allergic reaction of the eye. Tell your doctor if you have unlikely but serious side effects of Iopidine 0.5% including:

  • mental/mood changes (e.g., depression, irritability), or
  • slow or irregular heartbeat.

The dose of Iopidine Ophthalmic Solution is one to two drops instilled in the affected eye(s) three times daily. Since Iopidine will be used with other ocular glaucoma therapies, wait at least 5 minutes between uses of each medication. Iopidine may interact with blood pressure medications, or heart rhythm medication. Tell your doctor all prescription and over-the-counter medications and supplements you use. During pregnancy, Iopidine should be used only when prescribed. It is unknown if this medication passes into breast milk. Consult your doctor before breastfeeding.

Our Iopidine 0.5% (apraclonidine) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Iopidine Eye Consumer Information

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Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • severe itching, redness, or discomfort in or around your eye;
  • crusting or drainage around your eye;
  • eye pain or increased watering; or
  • feeling like something is in your eye.

Common side effects may include:

  • blurred vision;
  • dry eyes;
  • eye redness or watering, puffy eyelids;
  • dizziness, drowsiness; or
  • dry mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Iopidine Eye (Apraclonidine)


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Iopidine Eye Professional Information


The following adverse events, occurring in less than 2% of patients, were reported in association with the use of IOPIDINE 1% Ophthalmic Solution in laser surgery: ocular injection, upper lid elevation, irregular heart rate, nasal decongestion, ocular inflammation, conjunctival blanching, and mydriasis.

The following adverse events were observed in investigational studies dosing IOPIDINE 1% Ophthalmic Solution once or twice daily for up to 28 days in nonlaser studies:


Conjunctival blanching, upper lid elevation, mydriasis, burning, discomfort, foreign body sensation, dryness, itching, hypotony, blurred or dimmed vision, allergic response, conjunctival microhemorrhage.


Abdominal pain, diarrhea, stomach discomfort, emesis.


Bradycardia, vasovagal attack, palpitations, orthostatic episode.

Central Nervous System

Insomnia, dream disturbances, irritability, decreased libido.


Taste abnormalities, dry mouth, nasal burning or dryness, headache, head cold sensation, chest heaviness or burning, clammy or sweaty palms, body heat sensation, shortness of breath, increased pharyngeal secretion, extremity pain or numbness, fatigue, paresthesia, pruritus not associated with rash.

Clinical Practice

The following events have been identified during postmarketing use of IOPIDINE 1% Ophthalmic Solution in clinical practice. Because they are reported voluntarily from a population of unknown size, estimates of frequency cannot be made. The events, which have been chosen for inclusion due to either their seriousness, frequency of reporting, possible causal connection to IOPIDINE 1% Ophthalmic Solution, or a combination of these factors, include hypersensitivity.

Read the entire FDA prescribing information for Iopidine Eye (Apraclonidine)

© Iopidine Eye Patient Information is supplied by Cerner Multum, Inc. and Iopidine Eye Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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