Medical Editor: John P. Cunha, DO, FACOEP
Iopidine 0.5% (apraclonidine) is an alpha-adrenergic agonist, which decreases the amount of fluid in the eye, decreasing pressure in the eye, used to treat or prevent high pressure inside the eye caused by certain types of eye surgery or procedures. Iopidine 0.5% is available in generic form. Common side effects of Iopidine 0.5% include:
- eye discomfort/redness/burning/dryness,
- blurred or dimmed vision,
- feeling like something is in your eye,
- dry mouth,
- dry or stuffy nose,
- stomach pain or upset,
- sleep problems (insomnia), or
- unusual tiredness.
Eye itching or watering, or eyelid swelling or puffiness may be symptoms of an allergic reaction of the eye. Tell your doctor if you have unlikely but serious side effects of Iopidine 0.5% including:
- mental/mood changes (e.g., depression, irritability), or
- slow or irregular heartbeat.
The dose of Iopidine Ophthalmic Solution is one to two drops instilled in the affected eye(s) three times daily. Since Iopidine will be used with other ocular glaucoma therapies, wait at least 5 minutes between uses of each medication. Iopidine may interact with blood pressure medications, or heart rhythm medication. Tell your doctor all prescription and over-the-counter medications and supplements you use. During pregnancy, Iopidine should be used only when prescribed. It is unknown if this medication passes into breast milk. Consult your doctor before breastfeeding.
Our Iopidine 0.5% (apraclonidine) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:
- slow or uneven heart rate;
- pounding heartbeats or fluttering in your chest;
- shallow breathing, feeling like you might pass out;
- severe swelling, redness, or discomfort in or around your eye;
- eye pain or increased watering; or
- numbness or tingly feeling in your hands or feet.
Less serious side effects may include:
- burning, itching, or dryness of your eyes;
- feeling like something is in your eye;
- blurred or dimmed vision;
- redness of the eye or eyelid;
- mildly swollen or puffy eyes;
- nausea, stomach pain, diarrhea;
- headache, sleep problems (insomnia);
- dry or stuffy nose, burning in your nose;
- a dry mouth; or
- unusual or unpleasant taste in your mouth.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
Read the entire detailed patient monograph for Iopidine Eye (Apraclonidine)
In clinical studies the overall discontinuation rate related to IOPIDINE 0.5% Ophthalmic Solution was 15%. The most commonly reported events leading to discontinuation included (in decreasing order of frequency) hyperemia, pruritus, tearing, discomfort, lid edema, dry mouth, and foreign body sensation.
The following adverse reactions (incidences) were reported in clinical studies of IOPIDINE 0.5% (apraclonidine ophthalmic solution) as being possibly, probably, or definitely related to therapy:
The following adverse reactions were reported in 5 to 15% of the patients: discomfort, hyperemia, and pruritus.
The following adverse reactions were reported in less than 1% of the patients: abnormal vision, blepharitis, blepharoconjunctivitis, conjunctival edema, conjunctival follicles, corneal erosion, corneal infiltrate, corneal staining, edema, irritation, keratitis, keratopathy, lid disorder, lid erythema, lid margin crusting, lid retraction, lid scales, pain, photophobia.
Dry mouth occurred in approximately 10% of the patients.
The following adverse reactions were reported in less than 3% of the patients: abnormal coordination, asthenia, arrhythmia, asthma, chest pain, constipation, contact dermatitis, depression, dermatitis, dizziness, dry nose, dyspnea, facial edema, headache, insomnia, malaise, myalgia, nausea, nervousness, paresthesia, parosmia, peripheral edema, pharyngitis, rhinitis, somnolence, and taste perversion.
Clinical practice: The following events have been identified during post-marketing use of IOPIDINE® 0.5% Ophthalmic Solution in clinical practice. Because they are reported voluntarily from a population of unknown size, estimates of frequency cannot be made. The events, which have been chosen for inclusion due to either their seriousness, frequency of reporting, possible causal connection to IOPIDINE 0.5% Ophthalmic Solution, or a combination of these factors, include: bradycardia.
Read the entire FDA prescribing information for Iopidine Eye (Apraclonidine)
© Iopidine Eye Patient Information is supplied by Cerner Multum, Inc. and Iopidine Eye Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.