Medical Editor: John P. Cunha, DO, FACOEP
Isopto Atropine (atropine sulfate ophthalmic solution) 1%, for topical ophthalmic use is a muscarinic antagonist indicated for dilation of the pupils (mydriasis), paralysis of the ciliary muscle of the eye, and penalization of the healthy eye in the treatment of lazy eye (amblyopia). Common side effects of Isopto Atropine include:
- eye pain and stinging on administration,
- blurred vision,
- eye sensitivity to light,
- eye inflammation,
- decreased tearing,
- increased heart rate, and
- increased blood pressure,
- dry skin/mouth/throat,
- irritability, and
- flushed skin of the face and neck.
In individuals from three (3) months of age or greater the dose of Isopto Atropine is 1 drop applied topically to the cul-de-sac of the conjunctiva, forty minutes prior to the intended maximal dilation time, In individuals 3 years of age or greater, doses of Isopto Atropine may be repeated up to twice daily as needed. Isopto Atropine may interact with monoamine oxidase inhibitors (MAOIs). Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plan to become pregnant before using Isopto Atropine; it is unknown if it will affect a fetus. It is unknown if Isopto Atropine passes into breast milk or if it would affect a nursing baby. Consult your doctor before breastfeeding.
Our Isopto Atropine (atropine sulfate ophthalmic solution) 1%, for topical ophthalmic use Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
The following adverse reactions are described below and elsewhere in the labeling:
- Photophobia and Blurred Vision [see WARNINGS AND PRECAUTIONS]
- Elevation in Blood Pressure [see WARNINGS AND PRECAUTIONS]
- Increased Adverse Drug Reaction Susceptibility with Certain Central Nervous System Conditions [see WARNINGS AND PRECAUTIONS]
The following adverse reactions have been identified following use of atropine sulfate ophthalmic solution. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
Ocular Adverse Reactions
Eye pain and stinging occurs upon instillation of atropine sulfate ophthalmic solution. Other commonly occurring adverse reactions include blurred vision, photophobia, superficial keratitis and decreased lacrimation. Allergic reactions such as papillary conjunctivitis, contact dermatitis, and eyelid edema may also occur less commonly.
Systemic Adverse Reactions
Systemic effects of atropine are related to its anti-muscarinic activity. Systemic adverse events reported include dryness of skin, mouth, and throat from decreased secretions from mucus membranes; drowsiness; restlessness, irritability or delirium from stimulation of the central nervous system; tachycardia; flushed skin of the face and neck.
Read the entire FDA prescribing information for Isopto Atropine (Atropine Sulfate)