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Last reviewed on RxList: 2/27/2019
Isordil Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 2/27/2019

Isordil (isosorbide dinitrate) is a nitrate indicated for the prevention of angina due to coronary artery disease and congestive heart failure. Isordil is available in genericfomr. Common side effects of Isordil include:

  • headache,
  • weakness,
  • mild dizziness, and
  • skin changes such as redness, tingling, or warmth.

Serious side effects of Isordil include:

Isordil (isosorbide dinitrate) tablets come in strengths of 5 or 40 mg of isosorbide dinitrate. The usual starting dose of Isordil Titradose is 5 mg to 20 mg, two or three times daily. For maintenance therapy, 10 mg to 40 mg, two or three times daily, is recommended. Isordil may interact with blood pressure medications, dihydroergotamine or ergotamine, erectile dysfunction medications, beta-blockers, or calcium channel blockers. Tell your doctor all medications and supplements you use. It is not known if Isordil affects the fetus in pregnant women or if it occurs in breast milk. Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding before using Isordil. Safety and effectiveness of Isordil in pediatric patients have not been established.

Our Isordil Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Isordil Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;
  • worsening angina pain;
  • fast or slow heart rate; or
  • pounding heartbeats or fluttering in your chest.

Isosorbide dinitrate can cause severe headaches. These headaches may gradually become less severe as you continue to use nitroglycerin. Do not stop taking this medicine to avoid headaches. Ask your doctor before using any headache pain medication.

Common side effects may be more likely to occur, such as:

  • headache; or
  • flushing (warmth, redness, or tingly feeling).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Isordil (Isosorbide Dinitrate)


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Isordil Professional Information


Adverse reactions to isosorbide dinitrate are generally dose-related, and almost all of these reactions are the result of isosorbide dinitrate’s activity as a vasodilator. Headache, which may be severe, is the most commonly reported side effect. Headache may be recurrent with each daily dose, especially at higher doses. Transient episodes of lightheadedness, occasionally related to blood pressure changes, may also occur. Hypotension occurs infrequently, but in some patients it may be severe enough to warrant discontinuation of therapy. Syncope, crescendo angina, and rebound hypertension have been reported but are uncommon.

Extremely rarely, ordinary doses of organic nitrates have caused methemoglobinemia in normalseeming patients. Methemoglobinemia is so infrequent at these doses that further discussion of its diagnosis and treatment is deferred (see OVERDOSE).

Data are not available to allow estimation of the frequency of adverse reactions during treatment with Isordil Titradose tablets.

To report SUSPECTED ADVERSE REACTIONS, contact Valeant Pharmaceuticals North America LLC at 1-800-321-4576 or FDA at 1-800-FDA-1088 or

Read the entire FDA prescribing information for Isordil (Isosorbide Dinitrate)


In the U.S., 1 in every 4 deaths is caused by heart disease. See Answer
Related Resources for Isordil

© Isordil Patient Information is supplied by Cerner Multum, Inc. and Isordil Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.


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