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Januvia vs. Invokana

Are Januvia and Invokana the Same Thing?

Januvia (sitagliptin) and Invokana (canagliflozin) are oral diabetes medicines for people with type 2 diabetes (non-insulin-dependent) diabetes.

Januvia is sometimes used in combination with other diabetes medications, but is not for treating type 1 diabetes.

Side effects of Januvia and Invokana that are similar include constipation or nausea.

Side effects of Januvia that are different from Invokana include runny or stuffy nose, sore throat, headache, back pain, joint or muscle pain, stomach pain, or diarrhea.

Side effects of Invokana that are different from Januvia include urinary tract infections (UTIs), increased urination, yeast infections, vaginal itching, thirst, fatigue, weakness, skin, sensitivity to sunlight, hypersensitivity reactions (including skin redness, rash, itching, hives, and swelling), bone fractures, and kidney problems.

Both Januvia and Invokana may interact with digoxin.

Januvia may also interact with other anti-diabetic medications, probenecid, nonsteroidal anti-inflammatory drugs (NSAIDs), aspirin or other salicylates, sulfa drugs, monoamine oxidase inhibitors (MAOIs), or beta-blockers.

Invokana may also interact with rifampin.

What Are Possible Side Effects of Januvia?

Common side effects of Januvia include:

  • runny or stuffy nose,
  • sore throat,
  • headache,
  • back pain,
  • joint or muscle pain,
  • nausea,
  • stomach pain,
  • diarrhea, or
  • constipation.

Although Januvia by itself usually does not cause low blood sugar (hypoglycemia), low blood sugar may occur if Januvia is prescribed with other anti-diabetic medications. Symptoms of low blood sugar include sudden sweating, shaking, fast heartbeat, hunger, blurred vision, dizziness, or tingling hands/feet.

What Are Possible Side Effects of Invokana?

Common side effects of Invokana include:

  • urinary tract infections,
  • increased urination,
  • yeast infections,
  • vaginal itching,
  • thirst,
  • constipation,
  • nausea,
  • fatigue,
  • weakness,
  • skin sensitivity to sunlight,
  • hypersensitivity reactions (including skin redness, rash, itching, hives, and swelling),
  • bone fractures, and
  • kidney problems.

What Is Januvia?

Januvia (sitagliptin) is an oral diabetes medicine for people with type 2 diabetes (non-insulin-dependent) diabetes. Januvia is sometimes used in combination with other diabetes medications, but is not for treating type 1 diabetes. Many people using Januvia do not have serious side effects.

What Is Invokana?

Invokana (canagliflozin) is a sodium-glucose co-transporter 2 (SGLT2) inhibitor used to control blood sugar in people with type 2 diabetes mellitus, in addition to diet and exercise.

What Drugs Interact With Januvia?

Januvia may interact with digoxin, probenecid, non-steroidal anti-inflammatory drugs (NSAIDs), aspirin or other salicylates, sulfa drugs, monoamine oxidase inhibitors (MAOIs), or beta-blockers. Tell your doctor all prescription and over-the-counter medications you use. During pregnancy Januvia should be used only when prescribed. Pregnancy may cause or worsen diabetes. Your doctor may change your diabetes treatment during pregnancy. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

What Drugs Interact With Invokana?

Invokana may interact with rifampin or digoxin. Tell your doctor all medications you use. Invokana should only be given to a pregnant woman if the benefit of the drug justifies the risk of harm to the fetus.

How Should Januvia Be Taken?

The recommended dose of Januvia is 100 mg once daily.

How Should Invokana Be Taken?

The recommended starting dose of Invokana is 100 mg once daily, taken before the first meal of the day. Doses may be increased to 300 mg in patients who are able to tolerate Invokana at 100 mg doses.

Reviewed on 3/13/2019

References:
Merck. Januvia Product Information.
https://www.januvia.com
Janssen Pharmaceuticals, Inc. Invokana Product Information.
http://labeling.pfizer.com/showlabeling.aspx?id=579

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