Slideshows Images Quizzes

Copyright © 2018 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. See additional information.

Januvia vs. Onglyza

Medical and Pharmacy Editor:

Are Januvia and Onglyza the Same Thing?

Januvia (sitagliptin) and Onglyza (saxagliptin) are oral diabetes medicines for people with type 2 diabetes (non-insulin-dependent) diabetes.

Januvia and Onglyza are sometimes used in combination with other diabetes medications, but are not for treating type 1 diabetes.

Side effects of Januvia and Onglyza that are similar include runny or stuffy nose, sore throat, headache, or stomach pain.

Side effects of Januvia that are different from Onglyza include back pain, joint or muscle pain, nausea, diarrhea, or constipation.

Side effects of Onglyza that are different from Januvia include cough.

Both Januvia and Onglyza may interact with other anti-diabetic medications.

Januvia may also interact with digoxin, probenecid, nonsteroidal anti-inflammatory drugs (NSAIDs), aspirin or other salicylates, sulfa drugs, monoamine oxidase inhibitors (MAOIs), or beta-blockers.

Onglyza may also interact with tazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, ritonavir, saquinavir, and telithromycin.

What Are Possible Side Effects of Januvia?

Common side effects of Januvia include:

  • runny or stuffy nose,
  • sore throat,
  • headache,
  • back pain,
  • joint or muscle pain,
  • nausea,
  • stomach pain,
  • diarrhea, or
  • constipation.

Although Januvia by itself usually does not cause low blood sugar (hypoglycemia), low blood sugar may occur if Januvia is prescribed with other anti-diabetic medications. Symptoms of low blood sugar include sudden sweating, shaking, fast heartbeat, hunger, blurred vision, dizziness, or tingling hands/feet.

What Are Possible Side Effects of Onglyza?

Common side effects of Onglyza include:

Onglyza by itself usually does not cause low blood sugar (hypoglycemia), but low blood sugar may occur if this drug is prescribed with other anti-diabetic medications. Symptoms of low blood sugar include sudden sweating, shaking, fast heartbeat, hunger, blurred vision, dizziness, or tingling hands/feet. Get medical help if you have very serious side effects of Onglyza including:

  • signs of disease of the pancreas (such as severe stomach or abdominal pain which may spread to the back, or persistent nausea or vomiting).

What Is Januvia?

Januvia (sitagliptin) is an oral diabetes medicine for people with type 2 diabetes (non-insulin-dependent) diabetes. Januvia is sometimes used in combination with other diabetes medications, but is not for treating type 1 diabetes. Many people using Januvia do not have serious side effects.

What Is Onglyza?

Onglyza (saxagliptin) is an orally-active inhibitor of the DPP4 enzyme used either alone or with other medications, and with a proper diet and exercise program, to control high blood sugar. Onglyza is used in people with type 2 (non-insulin-dependent) diabetes.

What Drugs Interact With Januvia?

Januvia may interact with digoxin, probenecid, non-steroidal anti-inflammatory drugs (NSAIDs), aspirin or other salicylates, sulfa drugs, monoamine oxidase inhibitors (MAOIs), or beta-blockers. Tell your doctor all prescription and over-the-counter medications you use. During pregnancy Januvia should be used only when prescribed. Pregnancy may cause or worsen diabetes. Your doctor may change your diabetes treatment during pregnancy. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

What Drugs Interact With Onglyza?

Onglyza may interact with tazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, ritonavir, saquinavir, and telithromycin. Low blood sugar may occur if this drug is prescribed with other anti-diabetes medications. During pregnancy, Onglyza should be used only when prescribed. Pregnancy may cause or worsen diabetes. Your doctor may change your diabetes treatment during your pregnancy. It is unknown if this medication passes into breast milk. Consult your doctor before breastfeeding.

How Should Januvia Be Taken?

The recommended dose of Januvia is 100 mg once daily.

How Should Onglyza Be Taken?

The recommended dose of Onglyza is 2.5 mg or 5 mg once daily taken regardless of meals.

Reviewed on 3/13/2019

References:
Merck. Januvia Product Information.
https://www.januvia.com
AstraZeneca. Onglyza Product Information.
https://www.onglyza.com/

CONTINUE SCROLLING FOR RELATED SLIDESHOW

Health Solutions From Our Sponsors