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Jardiance vs. Fortamet, Glucophage, Glucophage XR

Are Jardiance and Fortamet, Glucophage, Glucophage XR the Same Thing?

Jardiance (empagliflozin) and Fortamet, Glucophage, and Glucophage XR (metformin hydrochloride) are anti-diabetes medicines used as adjuncts to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Jardiance is also indicated to reduce the risk of cardiovascular death in adult patients with type 2 diabetes mellitus and cardiovascular disease.

Side effects of Jardiance and Fortamet, Glucophage, and Glucophage XR that are similar include weakness or nausea.

Side effects of Jardiance that are different from Fortamet, Glucophage, and Glucophage XR include dehydration, dizziness, lightheadedness, yeast infection, low blood sugar, upper respiratory tract infection, high cholesterol, joint pain, increased urination, urinary tract infection (UTI), thirst, and low blood pressure (hypotension).

Side effects of Fortamet, Glucophage, and Glucophage XR that are different from Jardiance include headache, muscle pain, vomiting, stomach upset or pain, diarrhea, gas, or a metallic taste in the mouth.

Both Jardiance and Fortamet, Glucophage, and Glucophage XR may interact with diuretics (water pills).

Jardiance may also interact with insulin or insulin secretagogues.

Fortamet, Glucophage, and Glucophage XR may also interact with isoniazid, steroids, phenothiazines, thyroid medicines, birth control pills and other hormones, seizure medicines, diet pills, medicines to treat asthma, cold or allergy medicines, alcohol, nonsteroidal anti-inflammatory drugs (NSAIDs), aspirin or other salicylates, sulfa drugs, monoamine oxidase inhibitors (MAOIs), beta-blockers, probenecid, furosemide, nifedipine, cimetidine or ranitidine, amiloride or triamterene, digoxin, morphine, procainamide, quinidine, trimethoprim, or vancomycin.

What Are Possible Side Effects of Jardiance?

Common side effects of Jardiance include:

What Are Possible Side Effects of Fortamet, Glucophage, Glucophage XR?

Common side effects of Fortamet, Glucophage, Glucophage XR include:

  • headache,
  • muscle pain,
  • nausea,
  • vomiting,
  • stomach upset or pain,
  • diarrhea,
  • gas,
  • weakness, or
  • a metallic taste in the mouth

Fortamet, Glucophage, Glucophage XR does not usually cause low blood sugar (hypoglycemia). Low blood sugar may occur if Fortamet is prescribed with other anti-diabetic medications. Symptoms of low blood sugar include sudden sweating, shaking, fast heartbeat, hunger, blurred vision, dizziness, or tingling hands/feet. Tell your doctor if you experience serious side effects of Fortamet including shortness of breath, swelling or rapid weight gain, fever, body aches, or flu symptoms.

What Is Jardiance?

Jardiance (empagliflozin) is an inhibitor of the sodium-glucose co-transporter 2 (SGLT2) used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. Jardiance is also indicated to reduce the risk of cardiovascular death in adult patients with type 2 diabetes mellitus and cardiovascular disease.

What Is Fortamet, Glucophage, Glucophage XR?

Fortamet, Glucophage, Glucophage XR is an oral diabetes medicine for people with type 2 (non-insulin-dependent) diabetes. Metformin is sometimes used in combination with insulin or other medications, but it is not for treating type 1 diabetes.

What Drugs Interact With Jardiance?

Jardiance may interact with diuretics, insulin or insulin secretagogues. Tell your doctor all medications and supplements you use. During pregnancy, Jardiance should be taken only if prescribed. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

What Drugs Interact With Fortamet, Glucophage, Glucophage XR?

Fortamet, Glucophage, Glucophage XR hyperglycemia (high blood sugar) may result if you take Fortamet with drugs that raise blood sugar, such as: isoniazid, diuretics (water pills), steroids, phenothiazines, thyroid medicine, birth control pills and other hormones, seizure medicines, and diet pills, or medicines to treat asthma, colds or allergies. Hypoglycemia (low blood sugar) may result if you take Fortamet with drugs that lower blood sugar, such as: alcohol, non-steroidal anti-inflammatory drugs (NSAIDs), aspirin or other salicylates, sulfa drugs, monoamine oxidase inhibitors (MAOIs), beta-blockers, or probenecid. It may also interact with furosemide, nifedipine, cimetidine or ranitidine, amiloride or triamterene, digoxin, morphine, procainamide, quinidine, trimethoprim, or vancomycin. During pregnancy, Fortamet, Glucophage, Glucophage XR should be used only when prescribed. Your doctor may direct you to use insulin instead of this product during your pregnancy. This medication can cause changes in the menstrual cycle (promote ovulation) and increase the risk of becoming pregnant. Consult your doctor about the use of reliable birth control. This medication passes into breast milk in small amounts. Consult your doctor before breast-feeding.

How Should Jardiance Be Taken?

The recommended dose of Jardiance is 10 mg once daily in the morning, taken with or without food.

How Should Fortamet, Glucophage, Glucophage XR Be Taken?

The recommended starting dose of Fortamet, Glucophage, Glucophage XR should be taken once daily. Dosage is individualized based on effectiveness and tolerance. The maximum recommended daily dose is 2500 mg.

Reviewed on 3/13/2019

Medical Editor: John P. Cunha, DO, FACOEP

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