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Jardiance vs. Janumet

  • Medical and Pharmacy Editor: John P. Cunha, DO, FACOEP
    John P. Cunha, DO, FACOEP

    John P. Cunha, DO, FACOEP

    John P. Cunha, DO, is a U.S. board-certified Emergency Medicine Physician. Dr. Cunha's educational background includes a BS in Biology from Rutgers, the State University of New Jersey, and a DO from the Kansas City University of Medicine and Biosciences in Kansas City, MO. He completed residency training in Emergency Medicine at Newark Beth Israel Medical Center in Newark, New Jersey.

Are Jardiance and Janumet the Same Thing?

Jardiance (empagliflozin) and Janumet (sitagliptin/metformin HCl) are anti-diabetes medicines used as adjuncts to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Jardiance is also indicated to reduce the risk of cardiovascular death in adult patients with type 2 diabetes mellitus and cardiovascular disease.

Side effects of Jardiance and Janumet that are similar include weakness, nausea, or joint pain.

Side effects of Jardiance that are different from Janumet include dehydration, dizziness, lightheadedness, yeast infection, low blood sugar, upper respiratory tract infection, high cholesterol, increased urination, urinary tract infection (UTI), thirst, or low blood pressure (hypotension).

Side effects of Janumet that are different from Jardiance include vomiting, stomach upset, diarrhea, constipation, headache, back pain, muscle pain, a metallic taste in the mouth, or cold symptoms such as runny or stuffy nose, sneezing, and sore throat.

Both Jardiance and Janumet may interact with diuretics (water pills).

Jardiance may also interact with insulin or insulin secretagogues.

Janumet may also interact with isoniazid, steroids, phenothiazines, thyroid medicines, birth control pills and other hormones, seizure medicines, diet pills, medicines to treat asthma, cold or allergy medicines, nonsteroidal anti-inflammatory drugs (NSAIDs), aspirin or other salicylates, sulfa drugs, monoamine oxidase inhibitors (MAOIs), beta-blockers, probenecid, amiloride, triamterene, cimetidine, ranitidine, digoxin, furosemide, morphine, nifedipine, procainamide, quinidine, trimethoprim, or vancomycin.

What Are Possible Side Effects of Jardiance?

Common side effects of Jardiance include:

What Are Possible Side Effects of Janumet?

Common side effects of Janumet include:

  • nausea,
  • vomiting,
  • stomach upset,
  • diarrhea,
  • constipation,
  • headache,
  • weakness,
  • back pain,
  • joint or muscle pain,
  • a metallic taste in the mouth, or
  • cold symptoms such as runny or stuffy nose, sneezing, and sore throat.

Janumet does not usually cause low blood sugar (hypoglycemia). Low blood sugar may occur if Janumet is prescribed with other anti-diabetic medications. Symptoms of low blood sugar include sudden sweating, shaking, fast heartbeat, hunger, blurred vision, dizziness, or tingling hands/feet.

What Is Jardiance?

Jardiance (empagliflozin) is an inhibitor of the sodium-glucose co-transporter 2 (SGLT2) used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. Jardiance is also indicated to reduce the risk of cardiovascular death in adult patients with type 2 diabetes mellitus and cardiovascular disease.

What Is Janumet?

Janumet (sitagliptin/metformin HCl) is a combination of oral diabetes medicines for people with type 2 diabetes who do not use daily insulin injections. Janumet is not for treating type 1 diabetes.

What Drugs Interact With Jardiance?

Jardiance may interact with diuretics, insulin or insulin secretagogues. Tell your doctor all medications and supplements you use. During pregnancy, Jardiance should be taken only if prescribed. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

What Drugs Interact With Janumet?

Hyperglycemia (high blood sugar) may result if you take Janumet with drugs that raise blood sugar, such as: isoniazid, diuretics (water pills), steroids, phenothiazines, thyroid medicine, birth control pills and other hormones, seizure medicines, and diet pills, or medicines to treat asthma, colds or allergies. Hypoglycemia (low blood sugar) may result if you take Janumet with drugs that lower blood sugar, such as: nonsteroidal anti-inflammatory drugs (NSAIDs), aspirin or other salicylates, sulfa drugs, monoamine oxidase inhibitors (MAOIs), beta-blockers, or probenecid. It may also interact with amiloride, triamterene, cimetidine, ranitidine, digoxin, furosemide, morphine, nifedipine, procainamide, quinidine, trimethoprim, or vancomycin. Tell your doctor all medications you use. During pregnancy, Janumet should be used only when prescribed. Your doctor may direct you to use insulin instead of this product during your pregnancy. Metformin can promote ovulation and increase the risk of becoming pregnant. Consult your doctor about use of birth control. Metformin passes into breast milk in small amounts. It is unknown if sitagliptin passes into breast milk. Consult your doctor before breastfeeding.

How Should Jardiance Be Taken?

The recommended dose of Jardiance is 10 mg once daily in the morning, taken with or without food.

How Should Janumet Be Taken?

Dosage of Janumet is individualized. Janumet is given twice daily with meals in 50 mg sitagliptin/500 mg metformin hydrochloride or 50 mg sitagliptin/1000 mg metformin hydrochloride doses.

Reviewed on 3/12/2019

References:
Boehringer Ingelheim Pharmaceuticals, Inc. Jardiance Product Information.
https://www.jardiance.com/
Merck. Janumet Product Information.
https://www.merck.com/product/usa/pi_circulars/j/janumet/janumet_pi.pdf

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