Jencycla Side Effects Center

Last updated on RxList: 8/15/2022
Jencycla Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Is Jencycla?

Jencycla (norethindrone tablet) is a progestin-only oral contraceptive used to prevent pregnancy. Jencycla is available as a generic.

What Are Side Effects of Jencycla?

Side effects of Jencycla include:

  • irregular menstrual periods,
  • frequent and irregular bleeding,
  • headache,
  • breast tenderness,
  • nausea,
  • dizziness,
  • acne,
  • excess unwanted hair growth,
  • weight gain,
  • vomiting,
  • abdominal pain,
  • fatigue,
  • fluid retention (edema),
  • depression,
  • nervousness,
  • pain in extremities,
  • genital discharge,
  • breast pain,
  • suppressed lactation,
  • absence of menstruation,
  • anaphylactic reaction,
  • hypersensitivity,
  • hepatitis,
  • hair loss,
  • rash, and
  • itching

Cigarette smoking increases the risk of serious cardiovascular disease. Women who use oral contraceptives should be strongly advised not to smoke.

Jencycla may cause serious side effects including:

Get medical help right away, if you have any of the symptoms listed above.

Seek medical care or call 911 at once if you have the following serious side effects:

  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheartedness, or passing out;
  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

Dosage for Jencycla

Jencycla must be taken exactly as directed. The dose of Jencycla is one tablet taken every day, at the same time. Administration is continuous, with no interruption between pill packs.

Jencycla In Children

Safety and efficacy of Jencycla tablets have been established in women of reproductive age. Safety and efficacy are expected to be the same for postpubertal adolescents under the age of 16 and for users 16 years and older. Use of this product before menarche is not indicated.

What Drugs, Substances, or Supplements Interact with Jencycla?

Jencycla may interact with other medicines such as:

  • phenytoin,
  • carbamazepine,
  • barbiturates,
  • rifampin,
  • St. John's wort, and
  • bosentan

Tell your doctor all medications and supplements you use.

Jencycla During Pregnancy and Breastfeeding

Tell your doctor if you are pregnant or plan to become pregnant before using Jencycla; it is not indicated for use during pregnancy. Small amounts of Jencycla pass into breast milk and may reduce milk production. Consult your doctor before breastfeeding.

Additional Information

Our Jencycla (norethindrone tablet) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Jencycla Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • sudden vision loss, bulging eyes, or severe headache;
  • swelling, rapid weight gain;
  • unusual vaginal bleeding;
  • missed menstrual periods;
  • pelvic pain (especially on one side);
  • a breast lump;
  • a light-headed feeling, like you might pass out;
  • increased thirst, increased urination;
  • liver problems--loss of appetite, stomach pain (upper right side), dark urine, jaundice (yellowing of the skin or eyes); or
  • signs of a blood clot--sudden numbness or weakness, problems with vision or speech, chest pain, shortness of breath, swelling or redness in an arm or leg.

Common side effects may include:

  • irregular vaginal bleeding or spotting;
  • headache;
  • breast pain or swelling;
  • stomach pain, bloating, nausea, vomiting;
  • hair loss;
  • depressed mood, trouble sleeping;
  • weight gain; or
  • vaginal itching or discharge.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Jencycla Professional Information


Adverse reactions reported with the use of POPs include:

  • Menstrual irregularity is the most frequently reported side effect.
  • Frequent and irregular bleeding are common, while long duration of bleeding episodes and amenorrhea are less likely.
  • Headache, breast tenderness, nausea, and dizziness are increased among progestin-only oral contraceptive users in some studies.
  • Androgenic side effects such as acne, hirsutism, and weight gain occur rarely.

The following adverse reactions were also reported in clinical trials or during post-marketing experience:

Gastrointestinal Disorders

Vomiting, abdominal pain

General Disorders And Administration Site Conditions

Fatigue, edema

Psychiatric Disorders

Depression, nervousness

Musculoskeletal And Connective Tissue Disorders

Pain in extremity

Reproductive System And Breast Disorders

Genital discharge; breast pain, menstruation delayed, suppressed lactation, vaginal hemorrhage, menorrhagia, withdrawal bleed when product is stopped

Immune System Disorders

Anaphylactic/anaphylactoid reaction, hypersensitivity

Hepatobiliary Disorders

Hepatitis, jaundice cholestatic

Skin And Subcutaneous Tissue Disorders

Alopecia, rash, rash pruritic

Read the entire FDA prescribing information for Jencycla (Norethindrone Tablets)

© Jencycla Patient Information is supplied by Cerner Multum, Inc. and Jencycla Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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