Kantrex

Last updated on RxList: 6/14/2017
Kantrex Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 6/14/2017

Kantrex (kanamycin) Injection is an aminoglycoside antibiotic used to treat serious infections caused by bacteria. The brand name Kantrex is discontinued, but generic versions may be available. Common side effects of Kantrex (kanamycin) include pain or irritation where the injection was given, skin rash or itching, hives, allergic reaction, headache, fever, nausea, or vomiting.

Dosage of Kantrex is based on the patient's body weight. Kantrex may interact with other medicines that can harm the kidneys, other antibiotics, lithium, diuretics, methotrexate, pain or arthritis medicines, medicines used to treat ulcerative colitis, medicines used to prevent organ transplant rejection, antiviral medicines, or cancer medicines. Tell your doctor all medications and supplements you use. Kantrex can cause harm to a fetus. Use birth control, and tell your doctor if you become pregnant during treatment. This drug can pass into breast milk and may harm a nursing baby. Consult your doctor before breastfeeding.

Our Kantrex (kanamycin) Injection Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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Kantrex Professional Information

SIDE EFFECTS

Kanamycin has the potential to induce auditory and sometimes vestibular toxicity, renal toxicity, and neuromuscular blockade. The risks are higher for patients with a present or past history of renal impairment (especially if hemodialysis is required): for those receiving concomitant or sequential treatment with other ototoxic or nephrotoxic drugs or rapid acting diuretic agents given intravenously (ethacrynic acid, furosemide, and mannitol), and for patients treated for longer periods and/or with higher doses than recommended.

Ototoxicity

Toxic effects of kanamycin on the eighth cranial nerve can result in partially reversible or irreversible bilateral loss of hearing, loss of balance, or both. Tinnitus or vertigo may or may not be experienced. Cochlear damage is usually manifested initially by small changes in audiometric test results at the high frequencies and may not be associated with subjective hearing loss. Vestibular dysfunction is usually manifested by nystagmus, vertigo, nausea, vomiting, or acute Meniere's syndrome.

Nephrotoxicity

Albuminuria, presence of red and white cells, and granular casts; azotemia and oliguria have been reported. Renal function changes are usually reversible when the drug is discontinued. Renal impairment may be characterized by a rise in serum creatinine and may be accompanied by oliguria, presence of casts, cells, and protein in the urine, by rising levels of BUN or by decrease in creatinine clearance.

Neuromuscular Blockade

Acute muscular paralysis and apnea can occur following treatment with aminoglycoside antibiotics. Neurotoxicity can occur after intrapleural and interperitoneal instillation of large doses of an aminoglycoside; however, the reaction has followed intravenous, intramuscular, and even the oral administration of these agents.

Other

Some local irritation or pain may follow the intramuscular injection of kanamycin. Other adverse reactions of the drug reported on rare occasions are skin rash, drug fever, headache, paresthesia, nausea, vomiting, and diarrhea. The "malabsorption syndrome" characterized by an increase in fecal fat, decrease in serum carotene, and fall in xylose absorption, reportedly has occurred with prolonged therapy.

Read the entire FDA prescribing information for Kantrex (Kanamycin)

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© Kantrex Patient Information is supplied by Cerner Multum, Inc. and Kantrex Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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