Medical Editor: John P. Cunha, DO, FACOEP
Kemadrin (procyclidine hydrochloride) is an anticholinergic/antispasmodic drug used to treat symptoms of Parkinson's disease or involuntary movements due to the side effects of certain psychiatric drugs (antipsychotics such as chlorpromazine/haloperidol). The brand name Kemadrin is discontinued, but generic versions may be available. Common side effects of Kemadrin include:
- abdominal pain,
- blurred vision,
- weakness, or
- dry mouth
These effects usually lessen as your body gets used to Kemadrin.
The dosage of Kemadrin for the treatment of parkinsonism depends upon the age of the patient, the cause of the disease, and individual responsiveness. Kemadrin may interact with pramlintide, other amantadine, anticholinergics/antispasmodics, antiarrhythmics, cholinesterase inhibitors, corticosteroids, MAO inhibitors, motion sickness medications, narcotics, potassium tablets/capsules, antidepressants, or other drugs that cause drowsiness (such as antihistamines, anti-seizure drugs, medicine for sleep or anxiety, muscle relaxants, or psychiatric medicines). Tell your doctor all medications and supplements you use. During pregnancy, Kemadrin should be used only if prescribed. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.
Our Kemadrin (procyclidine hydrochloride) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
To relieve dry mouth, suck on (sugarless) hard candy or ice chips, chew (sugarless) gum, drink water, or use a saliva substitute.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor immediately if any of these unlikely but serious side effects occur: decreased sexual ability, severe stomach/abdominal pain, difficult/painful swallowing, difficulty urinating, weakness.
Get medical help right away if you have any very serious side effects, including: chest pain, severe dizziness/fainting, high fever, fast/irregular/slow heartbeat, mental/mood changes (e.g., confusion, hallucinations, memory problems), eye pain/swelling/redness, vision changes (such as seeing rainbows around lights at night).
A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Read the entire patient information overview for Kemadrin (Procyclidine Hydrochloride Tablets)
Anticholinergic effects can be produced by therapeutic doses although these can frequently be minimized or eliminated by careful dosage. They include: dryness of the mouth, mydriasis, blurring of vision, giddiness, lightheadedness, and gastrointestinal disturbances such as nausea, vomiting, epigastric distress, and constipation. Occasionally an allergic reaction such as a skin rash may be encountered. Feelings of muscular weakness may occur. Acute suppurative parotitis as a complication of dry mouth has been reported.
Read the entire FDA prescribing information for Kemadrin (Procyclidine Hydrochloride Tablets)