Kemadrin Side Effects Center

Last updated on RxList: 4/22/2019
Kemadrin Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 4/22/2019

Kemadrin (procyclidine hydrochloride) is an anticholinergic/antispasmodic drug used to treat symptoms of Parkinson's disease or involuntary movements due to the side effects of certain psychiatric drugs (antipsychotics such as chlorpromazine/haloperidol). The brand name Kemadrin is discontinued, but generic versions may be available. Common side effects of Kemadrin include:

  • drowsiness,
  • dizziness,
  • lightheadedness,
  • constipation,
  • flushing,
  • nausea,
  • vomiting,
  • abdominal pain,
  • nervousness,
  • blurred vision,
  • weakness, or
  • dry mouth

These effects usually lessen as your body gets used to Kemadrin.

The dosage of Kemadrin for the treatment of parkinsonism depends upon the age of the patient, the cause of the disease, and individual responsiveness. Kemadrin may interact with pramlintide, other amantadine, anticholinergics/antispasmodics, antiarrhythmics, cholinesterase inhibitors, corticosteroids, MAO inhibitors, motion sickness medications, narcotics, potassium tablets/capsules, antidepressants, or other drugs that cause drowsiness (such as antihistamines, anti-seizure drugs, medicine for sleep or anxiety, muscle relaxants, or psychiatric medicines). Tell your doctor all medications and supplements you use. During pregnancy, Kemadrin should be used only if prescribed. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

Our Kemadrin (procyclidine hydrochloride) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Parkinson's disease is only seen in people of advanced age. See Answer
Kemadrin Professional Information


Anticholinergic effects can be produced by therapeutic doses although these can frequently be minimized or eliminated by careful dosage. They include: dryness of the mouth, mydriasis, blurring of vision, giddiness, lightheadedness, and gastrointestinal disturbances such as nausea, vomiting, epigastric distress, and constipation. Occasionally an allergic reaction such as a skin rash may be encountered. Feelings of muscular weakness may occur. Acute suppurative parotitis as a complication of dry mouth has been reported.

Read the entire FDA prescribing information for Kemadrin (Procyclidine Hydrochloride Tablets)


Dementia, Alzheimer's Disease, and Aging Brains See Slideshow

© Kemadrin Patient Information is supplied by Cerner Multum, Inc. and Kemadrin Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

Health Solutions From Our Sponsors