Last updated on RxList: 10/5/2020
Ketalar Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Is Ketalar?

Ketalar (ketamine hydrochloride) Injection is a non-barbiturate anesthetic indicated for the induction of anesthesia either alone or prior to the administration of other general anesthetic agents. Ketalar is indicated to supplement low-potency agents, such as nitrous oxide. Ketalar is available in generic form.

What Are Side Effects of Ketalar?

Common side effects of Ketalar include:

Dosage for Ketalar?

It is formulated as a slightly acid (pH 3.5 – 5.5) sterile solution for intravenous or intramuscular injection in concentrations containing the equivalent of either 10, 50, or 100 mg ketamine base per milliliter and contains not more than 0.1 mg/mL Phemerol (benzethonium chloride) added as a preservative. The 10 mg/mL solution has been made isotonic with sodium chloride. Patients need to be accompanied until side effects wear off. The drug has the potential to become addictive.

What Drugs, Substances, or Supplements Interact with Ketalar?

Ketalar may interact with barbiturates or narcotics. Tell your doctor all medications and supplements you use.

Ketalar During Pregnancy and Breastfeeding

The use of Ketalar is not recommended for pregnant patients or for the use of obstetrics and has not been studied in pediatric patients below the age of 16.

Additional Information

Our Ketalar Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Ketalar Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers at once if you have any of these serious side effects within 24 hours after you receive ketamine: severe confusion, hallucinations, unusual thoughts, or extreme fear.

Call your doctor at once if you have:

  • painful or difficult urination, increased urination, loss of bladder control, blood in your urine;
  • a light-headed feeling, like you might pass out;
  • slow heart rate, weak or shallow breathing; or
  • jerky muscle movements that may look like convulsions.

Common side effects may include:

  • dream-like feeling;
  • blurred vision, double vision;
  • dizziness, drowsiness;
  • nausea, vomiting, loss of appetite; or
  • sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Ketalar (Ketamine Hydrochloride Injection)


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Ketalar Professional Information


The following clinically significant adverse reactions are described elsewhere in the labeling:

  • Hemodynamic Instability [see WARNINGS AND PRECAUTIONS]
  • Emergence Reactions [see WARNINGS AND PRECAUTIONS]
  • Respiratory Depression [see WARNINGS AND PRECAUTIONS]
  • Pediatric Neurotoxicity [see WARNINGS AND PRECAUTIONS]
  • Drug-Induced Liver Injury [see WARNINGS AND PRECAUTIONS]

The following adverse reactions associated with the use of KETALAR were identified in clinical studies or postmarketing reports. Because some of these reactions were reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

Cardiovascular disorders: Elevated blood pressure, heart rate, and cardiac index; decreases in blood pressure and heart rate; arrhythmias; cardiac decompensation (in patients with suspected catecholamine depletion).

Eye disorders: Diplopia, nystagmus, elevation in intraocular pressure.

Gastrointestinal disorders: Anorexia, nausea, vomiting, hepatobiliary dysfunction.

Administration site disorders: Local pain and exanthema at the injection site.

Immune system disorders: Anaphylaxis.

Neurologic disorders: Emergence reactions (post-operative delirium), [see WARNINGS AND PRECAUTIONS]. During administration, enhanced muscle tone and spasms (resembling a partial motor or generalized motor seizure).

Psychiatric disorders: Adverse psychiatric events have occurred and/or persisted days to weeks after ketamine exposure.

Renal and urinary disorders: In individuals with history of chronic ketamine use or abuse, lower urinary tract and bladder symptoms including dysuria, increased urinary frequency, urgency, urge incontinence, and hematuria have been reported [see DOSAGE AND ADMINISTRATION]. In addition, diagnostic studies performed to assess the cause of these symptoms have reported cystitis (including cystitis non-infective, cystitis interstitial, cystitis ulcerative, cystitis erosive and cystitis hemorrhagic) as well as hydronephrosis and reduced bladder capacity.

Respiratory disorders: Respiratory depression and apnea following rapid intravenous administration of high doses of KETALAR; laryngospasm, and airway obstruction.

Skin and subcutaneous tissue disorders: Transient erythema and/or morbilliform rash

Read the entire FDA prescribing information for Ketalar (Ketamine Hydrochloride Injection)

© Ketalar Patient Information is supplied by Cerner Multum, Inc. and Ketalar Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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