Kinlytic

Last reviewed on RxList: 4/3/2020
Kinlytic Side Effects Center

What Is Kinlytic?

Kinlytic (urokinase) for Injection is a thrombolytic agent used to treat blood clots in the lungs. The brand name Kinlytic is discontinued, but generic versions may be available.

What Are Side Effects of Kinlytic?

Common side effects of Kinlytic (urokinase) include:

  • easy bruising or
  • bleeding

Other side effects of Kinlytic are uncommon, but can be severe such as:

  • fever
  • stroke
  • trouble breathing
  • blood in your stools
  • coughing up blood
  • chest pain
  • problems with speech
  • vision problems
  • swelling
  • discoloration of your fingers or toes
  • severe stomach pain
  • chills, or
  • flu symptoms

See your doctor if you have any side effects.

Dosage for Kinlytic

The loading dose of 4,400 international units per kilogram of Kinlytic injection is given at a rate of 90 mL per hour over a period of 10 minutes. This is followed with a continuous infusion of 4,400 international units per kilogram per hour at a rate of 15 mL for 12 hours.

What Drugs, Substances, or Supplements Interact with Kinlytic?

Kinlytic may interact with blood thinners, aspirin or NSAIDs (nonsteroidal anti-inflammatory drugs), or medications used to prevent blood clots. Tell your doctor all medications and supplements you use.

Kinlytic During Pregnancy and Breastfeeding

Kinlytic is not expected to be harmful to a fetus. However, your doctor should know if you are pregnant before you receive this medication. It is unknown if this drug passes into breast milk or if it could harm a nursing baby. Consult your doctor before breastfeeding.

Additional Information

Our Kinlytic (urokinase) for Injection Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

QUESTION

In the U.S., 1 in every 4 deaths is caused by heart disease. See Answer
Kinlytic Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Urokinase increases your risk of bleeding, which can be severe or life-threatening. Call your doctor or seek emergency medical attention if you have bleeding that will not stop. Bleeding may occur from a surgical incision, or from the skin where a needle was inserted during a blood test or while receiving injectable medication. You may also have bleeding on the inside of your body, such as in your stomach or intestines, kidneys or bladder, brain, or within the muscles.

Call your doctor at once if you have signs of bleeding inside your body, such as:

  • easy bruising or bleeding (nosebleeds, bleeding gums, bleeding from a wound, incision, catheter, or needle injection);
  • bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
  • red or pink urine; or
  • sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance.

Some side effects may occur during or within 1 hour after the injection. Tell your caregiver right away if you feel chilled or feverish, nauseated, light-headed, or have chest tightness, back pain, trouble breathing, or fast heartbeats.

Also call your doctor at once if you have:

  • chest pain or heavy feeling, pain spreading to the jaw or shoulder, nausea, sweating, general ill feeling;
  • swelling, rapid weight gain, little or no urinating;
  • severe stomach pain, nausea, and vomiting;
  • darkening or purple discoloration of your fingers or toes;
  • very slow heartbeats, shortness of breath, feeling light-headed;
  • sudden severe back pain, muscle weakness, numbness or loss of feeling in your arms or legs;
  • dangerously high blood pressure--severe headache, blurred vision, pounding in your neck or ears, nosebleed, anxiety, confusion, severe chest pain, shortness of breath, irregular heartbeats; or
  • pancreatitis--severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Kinlytic (Urokinase Injection)

SLIDESHOW

Heart Disease: Symptoms, Signs, and Causes See Slideshow
Kinlytic Professional Information

SIDE EFFECTS

The most serious adverse reactions reported with Kinlytic™ (urokinase injection) administration include fatal hemorrhage and anaphylaxis (see WARNINGS).

Bleeding

Bleeding is the most frequent adverse reaction associated with Kinlytic™ and can be fatal (see WARNINGS).

In controlled clinical studies using a 12-hour infusion of urokinase for the treatment of pulmonary embolism (UPET and USPET),3,5,6 bleeding resulting in at least a 5% decrease in hematocrit was reported in 52 of 141 urokinase-treated patients. Significant bleeding events requiring transfusion of greater than 2 units of blood were observed during the 14-day study period in 3 of 141 urokinasetreated patients in these studies. Multiple bleeding events may have occurred in an individual patient. Most bleeding occurred at sites of external incisions and vascular puncture, with lesser frequency in gastrointestinal, genitourinary, intracranial, retroperitoneal, and intramuscular sites.

Sources of Information on Adverse Reactions

There are limited well-controlled clinical studies performed using urokinase. The adverse reactions described in the following sections reflect both the clinical use of Kinlytic™ (urokinase injection) in the general population and limited controlled study data. Because post-marketing reports of adverse reactions are voluntary and the population is of uncertain size, it is not always possible to reliably estimate the frequency of the reaction or establish a causal relationship to drug exposure.

Allergic Reactions

Rare cases of fatal anaphylaxis have been reported (see WARNINGS). In controlled clinical trials, allergic reaction was reported in 1 of 141 patients ( < 1%).

The following allergic-type reactions have been observed in clinical trials and/or post-marketing experience: bronchospasm, orolingual edema, urticaria, skin rash, and pruritus (see WARNINGS).

Infusion reaction symptoms include hypoxia, cyanosis, dyspnea, tachycardia, hypotension, hypertension, acidosis, fever and/or chills/rigors, back pain, vomiting, and nausea (see WARNINGS).

Other Adverse Reactions

Other adverse events occurring in patients receiving Kinlytic™ (urokinase injection) therapy in clinical studies, regardless of causality, include myocardial infarction, recurrent pulmonary embolism, hemiplegia, stroke, decreased hematocrit, substernal pain, thrombocytopenia, and diaphoresis.

Additional adverse reactions reported from post-marketing experience include cardiac arrest, vascular embolization (cerebral and distal) including cholesterol emboli (see WARNINGS), cerebral vascular accident, pulmonary edema, reperfusion ventricular arrhythmias and chest pain. A cause and effect relationship has not been established.

Immunogenicity

The immunogenicity of Kinlytic™ (urokinase injection) has not been studied.

Read the entire FDA prescribing information for Kinlytic (Urokinase Injection)

© Kinlytic Patient Information is supplied by Cerner Multum, Inc. and Kinlytic Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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