Kionex Side Effects Center

Last updated on RxList: 8/23/2022
Kionex Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Is Kionex?

Kionex (sodium polystyrene sulfonate) is a cation-exchange resin that works by helping your body get rid of extra potassium and is used to treat high levels of potassium in the blood, also called hyperkalemia. Kionex is available in generic form.

What Are Side Effects of Kionex?

Common side effects of Kionex include:

Tell your doctor if you have serious side effects of Kionex including:

  • muscle weakness or spasms,
  • fast or irregular heartbeat,
  • mental/mood changes (such as irritability, confusion, slowed thinking), or
  • swelling hands/ankles/feet.

Kionex may cause serious side effects including:

  • hives,
  • difficulty breathing,
  • swelling of your face, lips, tongue, or throat,
  • stomach pain,
  • rectal pain,
  • severe constipation,
  • severe stomach pain,
  • bloating,
  • fever,
  • chills,
  • vomiting,
  • confusion,
  • thinking problems,
  • feeling irritable,
  • leg cramps,
  • constipation,
  • irregular heartbeats,
  • fluttering in your chest,
  • increased thirst or urination,
  • numbness or tingling,
  • muscle weakness,
  • limp feeling,
  • muscle spasms or contractions,
  • numbness or tingly feeling (around your mouth, or in your fingers and toes),
  • bloody or tarry stools,
  • coughing up blood, and
  • vomit that looks like coffee grounds

Seek medical care or call 911 at once if you have the following serious side effects:

  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheartedness, or passing out;
  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

Dosage for Kionex

The average daily adult dose of Kionex resin is 15 g to 60 g. This is best provided by administering 15 grams (approximately 4 level teaspoons) of Kionex one to four times daily.

What Drugs, Substances, or Supplements Interact with Kionex?

Kionex may interact with digoxin, lithium, thyroxine, or diuretics (water pills). Tell your doctor all medications and supplements you use.

Kionex During Pregnancy and Breastfeeding

During pregnancy, Kionex should be used only when prescribed. It is unknown if this drug passes into breast milk, and the effect on a nursing infant is unknown. Consult your doctor before breastfeeding.

Additional Information

Our Kionex (sodium polystyrene sulfonate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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Kionex Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using sodium polystyrene sulfonate and call your doctor at once if you have:

  • stomach pain, rectal pain;
  • severe constipation, severe stomach pain, bloating;
  • fever, chills, vomiting;
  • confusion, thinking problems, feeling irritable;
  • low potassium--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling;
  • low calcium levels--muscle spasms or contractions, numbness or tingly feeling (around your mouth, or in your fingers and toes); or
  • signs of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds.

Common side effects may include:

  • nausea, vomiting;
  • diarrhea, constipation; or
  • loss of appetite.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Kionex (Sodium Polystyrene Sulfonate)

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Kionex Professional Information

SIDE EFFECTS

Kionex® Suspension may cause some degree of gastric irritation. Anorexia, nausea, vomiting, and constipation may occur especially if high doses are given. Also, hypokalemia, hypocalcemia, and significant sodium retention may occur. (See WARNINGS) Occasionally diarrhea develops. Large doses in elderly individuals may cause fecal impaction (See PRECAUTIONS). Rare instances of colonic necrosis have been reported. Intestinal obstruction due to concretions of aluminum hydroxide, when used in combination with sodium polystyrene sulfonate, has been reported.

The following events have been reported from worldwide post marketing experience with sodium polystyrene sulfonate powder:

  • fecal impaction following rectal administration, particularly in children;
  • gastrointestinal concretions (bezoars) following oral administration;
  • gastrointestinal tract ulceration or necrosis which could lead to intestinal perforation; and,
  • rare cases of acute bronchitis and/or bronchopneumonia associated with inhalation of particles of polystyrene sulfonate.

Read the entire FDA prescribing information for Kionex (Sodium Polystyrene Sulfonate)

© Kionex Patient Information is supplied by Cerner Multum, Inc. and Kionex Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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