- What other names is Krill Oil known by?
- What is Krill Oil?
- How does Krill Oil work?
- Are there safety concerns?
- Are there any interactions with medications?
- Dosing considerations for Krill Oil.
Aceite de Krill, Acide Docosahexaénoïque, Acides Gras Oméga 3, Acides Gras N-3, Acides Gras Polyinsaturés, Acides Gras W3, Antarctic Krill Oil, Concentré de Protéines Marines, DHA, Docosahexanoic Acid, EPA, Euphausia Superba Oil, Euphausiacé, Euphausiids Oil, Huile d' Euphausia Superba, Huile de Krill, Huile de Krill Antarctique, Huile d'Oméga 3, Marine Protein Concentrate, n-3 Fatty Acids, Omega 3, Omega-3 Fatty Acids, Omega-3, Oméga 3, Omega-3 Fatty Acids, Omega-3 Oil, Polyunsaturated Fatty Acids, W-3 Fatty Acids.
Krill oil is oil from a tiny, shrimp-like animal. Baleen whales, mantas, and whale sharks eat primarily krill. In Norwegian, the word "krill" means "whale food." People extract the oil from krill, place it in capsules, and use it for medicine. Some brand name krill oil products indicate that they use Antarctic krill. This usually refers to the species of krill called Euphausia superba.
Krill oil is used for heart disease, high levels of certain blood fats (triglycerides), high cholesterol, high blood pressure, stroke, cancer, osteoarthritis, depression, premenstrual syndrome (PMS), and painful menstrual periods.
Insufficient Evidence to Rate Effectiveness for...
- High cholesterol. Developing research shows that taking 1-1.5 grams of a specific krill oil product (Neptune Krill Oil, Neptune Technologies & Bioresources, Inc) daily reduces total cholesterol and “bad” low-density lipoprotein (LDL) cholesterol, and increases “good” high-density lipoprotein (HDL) cholesterol in patients with high cholesterol. Higher doses of 2-3 grams daily also appear to significantly reduce levels of triglyceride, another type of blood fat.
- Osteoarthritis. Early research shows that taking 300 mg of a specific krill oil product daily reduces pain and stiffness in people with osteoarthritis.
- Premenstrual syndrome (PMS). Early research shows that taking a specific krill oil product might reduce PMS symptoms.
- Rheumatoid arthritis. Early research shows that taking 300 mg of a specific krill oil product daily reduces pain and stiffness in people with rheumatoid arthritis.
- High blood pressure.
- Other conditions.
Krill oil contains fatty acids similar to fish oil. These fats are thought to be beneficial fats that decrease swelling, lower cholesterol, and make blood platelets less sticky. When blood platelets are less sticky they are less likely to form clots.
Krill oil is POSSIBLY SAFE for most adults when used appropriately for a short amount of time (up to three months). Research on krill oil has not adequately evaluated its safety or possible side effects. However, it is likely that krill oil can cause some side effects similar to fish oil such as bad breath, heartburn, fishy taste, upset stomach, nausea, and loose stools.
Special Precautions & Warnings:Pregnancy and breast-feeding: Not enough is known about the use of krill oil during pregnancy and breast-feeding. Stay on the safe side and avoid use.
Seafood allergy: Some people who are allergic to seafood might also be allergic to krill oil supplements. There is no reliable information showing how likely people with seafood allergy are to have an allergic reaction to krill oil; however, until more is known, avoid using krill oil or use it cautiously if you have a seafood allergy.
Surgery: Because krill oil can slow blood clotting, there is concern that it might increase the risk of bleeding during and after surgery. Stop using krill oil at least 2 weeks before a scheduled surgery.
Medications for diabetes (Antidiabetes drugs)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Krill oil might lower blood sugar. Diabetes medications are also used to lower blood sugar. Taking krill oil along with diabetes medications might cause your blood sugar to go too low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.
Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.
Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Krill oil might slow blood clotting. Taking krill oil along with medications that also slow clotting might increase the chances of bruising and bleeding.
Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.
Orlistat (Xenical, Alli)Interaction Rating: Minor Be cautious with this combination.Talk with your health provider.
Orlistat (Xenical, Alli) is used for weight loss. It prevents dietary fats from being absorbed from the gut. There is some concern that orlistat (Xenical, Alli) might also decrease absorption of krill oil when they are taken together. To avoid this potential interaction take orlistat (Xenical, Alli) and krill oil at least 2 hours apart.
The appropriate dose of krill oil depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for krill oil. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).
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Banni, S., Carta, G., Murru, E., Cordeddu, L., Giordano, E., Sirigu, A. R., Berge, K., Vik, H., Maki, K. C., Di, Marzo, V, and Griinari, M. Krill oil significantly decreases 2-arachidonoylglycerol plasma levels in obese subjects. Nutr Metab (Lond) 2011;8(1):7. View abstract.
Batetta, B., Griinari, M., Carta, G., Murru, E., Ligresti, A., Cordeddu, L., Giordano, E., Sanna, F., Bisogno, T., Uda, S., Collu, M., Bruheim, I., Di, Marzo, V, and Banni, S. Endocannabinoids may mediate the ability of (n-3) fatty acids to reduce ectopic fat and inflammatory mediators in obese Zucker rats. J Nutr 2009;139(8):1495-1501. View abstract.
Bengtson Nash, S. M., Poulsen, A. H., Kawaguchi, S., Vetter, W., and Schlabach, M. Persistent organohalogen contaminant burdens in Antarctic krill (Euphausia superba) from the eastern Antarctic sector: a baseline study. Sci Total Environ 12-15-2008;407(1):304-314. View abstract.
Bridges, K. M., Gigliotti, J. C., Altman, S., Jaczynski, J., and Tou, J. C. Determination of digestibility, tissue deposition, and metabolism of the omega-3 fatty acid content of krill protein concentrate in growing rats. J Agric.Food Chem 3-10-2010;58(5):2830-2837. View abstract.
Chen, Y. C., Tou, J. C., and Jaczynski, J. Amino acid and mineral composition of protein and other components and their recovery yields from whole Antarctic krill (Euphausia superba) using isoelectric solubilization/precipitation. J Food Sci 2009;74(2):H31-H39. View abstract.
Cipro, C. V., Taniguchi, S., and Montone, R. C. Occurrence of organochlorine compounds in Euphausia superba and unhatched eggs of Pygoscelis genus penguins from Admiralty Bay (King George Island, Antarctica) and estimation of biomagnification factors. Chemosphere 2010;78(6):767-771. View abstract.
Corsolini, S., Borghesi, N., Schiamone, A., and Focardi, S. Polybrominated diphenyl ethers, polychlorinated dibenzo-dioxins, -furans, and -biphenyls in three species of Antarctic penguins. Environ Sci Pollut.Res Int 2007;14(6):421-429. View abstract.
Gigliotti, J. C., Smith, A. L., Jaczynski, J., and Tou, J. C. Consumption of krill protein concentrate prevents early renal injury and nephrocalcinosis in female Sprague-Dawley rats. Urol.Res 2011;39(1):59-67. View abstract.
Guerin, M., Huntley, M. E., and Olaizola, M. Haematococcus astaxanthin: applications for human health and nutrition. Trends Biotechnol. 2003;21(5):210-216. View abstract.
Hatanaka, A., Miyahara, H., Suzuki, K. I., and Sato, S. Isolation and identification of antihypertensive peptides from antarctic krill tail meat hydrolysate. J Food Sci 2009;74(4):H116-H120. View abstract.
Hellgren, K. Assessment of Krillase chewing gum for the reduction of gingivitis and dental plaque. J Clin Dent 2009;20(3):99-102. View abstract.
Ierna, M., Kerr, A., Scales, H., Berge, K., and Griinari, M. Supplementation of diet with krill oil protects against experimental rheumatoid arthritis. BMC Musculoskelet.Disord. 2010;11:136. View abstract.
Kidd, P. M. Krill oil complex: potent nutraceutical synergy. Total Health 2003;25(4):15.
Kidd, P. M. Omega-3 DHA and EPA for cognition, behavior, and mood: clinical findings and structural-functional synergies with cell membrane phospholipids. Altern Med Rev 2007;12(3):207-227. View abstract.
Le, Grandois J., Marchioni, E., Zhao, M., Giuffrida, F., Ennahar, S., and Bindler, F. Investigation of natural phosphatidylcholine sources: separation and identification by liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS2) of molecular species. J Agric.Food Chem 7-22-2009;57(14):6014-6020. View abstract.
Lee, B., Sur, B. J., Han, J. J., Shim, I., Her, S., Lee, H. J., and Hahm, D. H. Krill phosphatidylserine improves learning and memory in Morris water maze in aged rats. Prog.Neuropsychopharmacol.Biol Psychiatry 8-16-2010;34(6):1085-1093. View abstract.
Lukas, R., Gigliotti, J. C., Smith, B. J., Altman, S., and Tou, J. C. Consumption of different sources of omega-3 polyunsaturated fatty acids by growing female rats affects long bone mass and microarchitecture. Bone 2011;49(3):455-462. View abstract.
Maki, K. C., Reeves, M. S., Farmer, M., Griinari, M., Berge, K., Vik, H., Hubacher, R., and Rains, T. M. Krill oil supplementation increases plasma concentrations of eicosapentaenoic and docosahexaenoic acids in overweight and obese men and women. Nutr.Res. 2009;29(9):609-615. View abstract.
McKenney, J. M. and Sica, D. Role of prescription omega-3 fatty acids in the treatment of hypertriglyceridemia. Pharmacotherapy 2007;27(5):715-728. View abstract.
Mori, T. A. Omega-3 fatty acids and hypertension in humans. Clin Exp Pharmacol Physiol 2006;33(9):842-846. View abstract.
Pacheco, P. H., Spisso, A., Cerutti, S., Smichowski, P., and Martinez, L. D. Non-chromatographic screening method for the determination of mercury species. Application to the monitoring of mercury levels in Antarctic samples. Talanta 9-15-2010;82(4):1505-1510. View abstract.
Piscitelli, F., Carta, G., Bisogno, T., Murru, E., Cordeddu, L., Berge, K., Tandy, S., Cohn, J. S., Griinari, M., Banni, S., and Di, Marzo, V. Effect of dietary krill oil supplementation on the endocannabinoidome of metabolically relevant tissues from high-fat-fed mice. Nutr Metab (Lond) 2011;8(1):51. View abstract.
Schuchardt, J. P., Schneider, I., Meyer, H., Neubronner, J., von, Schacky C., and Hahn, A. Incorporation of EPA and DHA into plasma phospholipids in response to different omega-3 fatty acid formulations--a comparative bioavailability study of fish oil vs. krill oil. Lipids Health Dis 2011;10:145. View abstract.
Tou, J. C., Jaczynski, J., and Chen, Y. C. Krill for human consumption: nutritional value and potential health benefits. Nutr Rev 2007;65(2):63-77. View abstract.
Winther, B., Hoem, N., Berge, K., and Reubsaet, L. Elucidation of phosphatidylcholine composition in krill oil extracted from Euphausia superba. Lipids 2011;46(1):25-36. View abstract.
Wu, Z., Jiang, G., Xiang, P., Yang, D., and Wang, N. Purification and characterization of trypsin-like enzymes from North Pacific krill (Euphausia pacifica). Biotechnol.Lett 2008;30(1):67-72. View abstract.
Yamada, H., Ueda, T., and Yano, A. Water-soluble extract of Pacific Krill prevents triglyceride accumulation in adipocytes by suppressing PPARgamma and C/EBPalpha expression. PLoS.One. 2011;6(7):e21952. View abstract.
Zhu, J. J., Shi, J. H., Qian, W. B., Cai, Z. Z., and Li, D. Effects of krill oil on serum lipids of hyperlipidemic rats and human SW480 cells. Lipids Health Dis 2008;7:30. View abstract.
Bottino NR. Lipid composition of two species of Antarctic krill: Euphausia superba and E. crystallorophias. Comp Biochem Physiol B 1975;50:479-84. View abstract.
Bunea R, El Farrah K, Deutsch L. Evaluation of the effects of Neptune Krill Oil on the clinical course of hyperlipidemia. Altern Med Rev 2004;9:420-8. View abstract.
Calder PC. N-3 polyunsaturated fatty acids, inflammation and immunity: pouring oil on troubled waters or another fishy tale? Nutr Res 2001;21:309-41.
Connor WE. n-3 Fatty acids from fish and fish oil: panacea or nostrum? Am J Clin Nutr 2001;74;415-6. View abstract.
Deutsch L. Evaluation of the effect of Neptune Krill Oil on chronic inflammation and arthritic symptoms. J Am Coll Nutr 2007;26:39-48. View abstract.
Dunlap WC, Fujisawa A, Yamamoto Y, et al. Notothenioid fish, krill and phytoplankton from Antarctica contain a vitamin E constituent (alpha-tocomonoenol) functionally associated with cold-water adaptation. Comp Biochem Physiol B Biochem Mol Biol 2002;133:299-305. View abstract.
Foran SE, Flood JG, Lewandrowski KB. Measurement of mercury levels in concentrated over-the-counter fish oil preparations: is fish oil healthier than fish? Arch Pathol Lab Med 2003;127:1603-5. View abstract.
Harris WS, Miller M, Tighe AP, et al. Omega-3 fatty acids and coronary heart disease risk: clinical and mechanistic perspectives. Atherosclerosis 2008;197:12-24. View abstract.
Leaf A. On the reanalysis of the GISSI-Prevenzione. Circulation 2002;105:1874-5. View abstract.
Melanson SF, Lewandrowski EL, Flood JG, Lewandrowski KB. Measurement of organochlorines in commercial over-the-counter fish oil preparations: implications for dietary and therapeutic recommendations for omega-3 fatty acids and a review of the literature. Arch Pathol Lab Med 2005;129:74-7. View abstract.
Multi-center, double-blind, placebo-controlled, monotherapy study of Neptune Krill oil (NKO™) in early stage Alzheimer's disease. 2009;
Sampalis F, Bunea R, Pelland MF, et al. Evaluation of the effects of Neptune Krill Oil on the management of premenstrual syndrome and dysmenorrhea. Altern Med Rev 2003;8:171-9. View abstract.
Tandy S, Chung RW, Wat E, et al. Dietary krill oil supplementation reduces hepatic steatosis, glycemia, and hypercholesterolemia in high-fat-fed mice. J Agric Food Chem 10-14-2009;57:9339-45. View abstract.
Ulven SM, Kirkhus B, Lamglait A, et al. Metabolic effects of krill oil are essentially similar to those of fish oil but at lower dose of EPA and DHA, in healthy volunteers. Lipids 2011;46:37-46. View abstract.
Venkatraman JT, Chandrasekar B, Kim JD, Fernandes G. Effects of n-3 and n-6 fatty acids on the activities and expression of hepatic antioxidant enzymes in autoimmune-prone NZBxNZW F1 mice. Lipids 1994;29:561-8. View abstract.