Kyprolis

Last updated on RxList: 07/12/2021
Kyprolis Patient Information Including Side Effects

Brand Names: Kyprolis

Generic Name: carfilzomib

What is carfilzomib (Kyprolis)?

Carfilzomib is used to treat multiple myeloma. Carfilzomib is sometimes given with other medicines when treating relapsed multiple myeloma.

Carfilzomib is given after other medicines did not work or have stopped working.

Carfilzomib may also be used for purposes not listed in this medication guide.

What are the possible side effects of carfilzomib (Kyprolis)?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Some side effects may occur within 24 hours after the injection. Tell your caregiver right away if you feel weak, nauseated, chilled or feverish, light-headed, or if you have joint or muscle pain, a cold sweat, chest pain or tightness, trouble breathing, or swelling in your face.

Carfilzomib may cause a serious brain infection that can lead to disability or death. Call your doctor right away if you have problems with speech, thought, vision, or muscle movement. These symptoms may start gradually and get worse quickly.

Also call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;
  • easy bruising or bleeding (nosebleeds, bleeding gums), or any bleeding that will not stop;
  • vomiting, diarrhea, weakness, blood in your stools, coughing up blood or vomit that looks like coffee grounds;
  • headache, confusion, dizziness, problems with balance;
  • a seizure;
  • jaundice (yellowing of the skin or eyes);
  • heart problems--chest pain, pain spreading to your jaw or shoulder, pounding in your neck or ears, blurred vision, severe headache;
  • kidney problems--little or no urination, swelling in your feet or ankles, feeling tired or short of breath;
  • low blood cell counts--fever, chills, tiredness, mouth sores, skin sores, pale skin, cold hands and feet;
  • lung problems--shortness of breath (even while lying down), wheezing, blue colored lips and skin, cough with foamy mucus;
  • low potassium level--leg cramps, irregular heartbeats, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling;
  • signs of a blood clot--sudden numbness or weakness, slurred speech, pain or redness in an arm or leg; or
  • signs of tumor cell breakdown--weakness, muscle cramps, nausea, vomiting, fast or slow heart rate, decreased urination, tingling in your hands and feet or around your mouth.

Common side effects may include:

  • fever, bruising, pale skin or other signs of low blood cell counts;
  • feeling short of breath;
  • low potassium;
  • nausea, diarrhea;
  • cold symptoms such as stuffy nose, sneezing, cough, sore throat;
  • muscle spasm;
  • swelling in your hands or feet; or
  • headache, trouble sleeping, feeling tired.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about carfilzomib (Kyprolis)?

Carfilzomib can affect your heart or lungs. Call your doctor at once if you have chest pain, pounding heartbeats, shortness of breath (even with mild exertion or while lying down), swelling of your hands or feet, feeling like you might pass out, wheezing, gasping for breath, cough with foamy mucus, or blue colored appearance of your lips and skin.

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Kyprolis Patient Information including How Should I Take

What should I discuss with my healthcare provider before receiving carfilzomib (Kyprolis)?

Tell your doctor if you have ever had:

Carfilzomib can harm an unborn baby if the mother or the father is using this medicine.

  • If you are a woman, do not use carfilzomib if you are pregnant. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 6 months after your last dose.
  • If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose.
  • Tell your doctor right away if a pregnancy occurs while either the mother or the father is using carfilzomib.

Do not breastfeed while using this medicine, and for at least 2 weeks after your last dose.

How is carfilzomib given (Kyprolis)?

Carfilzomib is given as an infusion into a vein. A healthcare provider will give you this injection.

Carfilzomib is given in a 28-day treatment cycle. You will receive an injection only on certain days of this cycle.

You may be given other medications to help prevent serious side effects or infections. Keep using these medicines for as long as your doctor has prescribed.

You will need frequent medical tests, and your next dose may be delayed based on the results.

Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while receiving this medication. Avoid dehydration by drinking plenty of liquids before and after your injections.

Kyprolis Patient Information including If I Miss a Dose

What happens if I miss a dose (Kyprolis)?

Call your doctor for instructions if you miss an appointment for your carfilzomib injection.

What happens if I overdose (Kyprolis)?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while receiving carfilzomib (Kyprolis)?

Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.

What other drugs will affect carfilzomib (Kyprolis)?

Other drugs may affect carfilzomib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information (Kyprolis)?

Your pharmacist can provide more information about carfilzomib.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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