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Lamictal vs. Depakote

Medical and Pharmacy Editor:

Are Lamictal and Depakote the Same Thing?

Lamictal (lamotrigine) and Depakote (divalproex sodium) are antiepileptic drugs (AEDs), also called anticonvulsants, used alone or in combination with other antiseizure medications for treating certain types of seizures.

Depakote (divalproex sodium) is also used to treat manic episodes associated with bipolar disorder, and migraine headaches.

What Are Possible Side Effects of Lamictal?

Lamictal may cause serious side effects, including:

Serious side effects of Lamictal you should report to your doctor include:

What Are Possible Side Effects of Depakote?

Common side effects of Depakote include:

  • drowsiness,
  • weakness,
  • nausea,
  • vomiting,
  • stomach upset,
  • diarrhea,
  • constipation,
  • mood swings,
  • changes in menstrual periods,
  • enlarged breasts,
  • weight changes,
  • agitation,
  • tremor (shaking),
  • vision changes,
  • unusual or unpleasant taste in your mouth, and
  • hair loss.

What is Lamictal?

Lamictal (lamotrigine) is an anticonvulsant used alone or in combination with other antiseizure medications for treating certain types of seizures.

What is Depakote?

Depakote (divalproex sodium) is a stable coordination compound comprised of sodium valproate and valproic acid used to treat manic episodes associated with bipolar disorder, epilepsy, and migraine headaches. Generic Depakote (termed divalproex sodium) is available under several other names.

What Drugs Interact With Lamictal?

Lamictal may interact with carbamazepine, phenytoin, phenobarbital, primidone, or rifampin.

Lamictal may also interact with hormonal forms of birth control (pills, injections, implants, or skin patches), divalproex, oxcarbazepine, or valproic acid.

What Drugs Interact With Depakote?

Depakote may interact with carbamazepine, phenytoin, phenobarbital, primidone, or rifampin.

Depakote may also interact with ritonavir, aspirin, carbapenem antibiotics, felbamate, amitriptyline, nortriptyline, clonazepam, diazepam, ethosuximide, lamotrigine, tolbutamide, warfarin, zidovudine, lorazepam, and topiramate.

How Should Lamictal Be Taken?

  • Lamictal doses depend on the condition being treated and on whether it is used alone or in combination with other antiseizure medications.

How Should Depakote Be Taken?

  • The recommended initial dose of Depakote to treat mania is 750 mg daily in divided doses. The dose of Depakote to treat epilepsy as monotherapy should be initiated at 10 to 15 mg/kg/day. The recommended starting dose of Depakote to treat migraines is 250 mg twice daily.
Reviewed on 1/3/2018

References:
RxList. Lamictal Medication Guide.
https://www.rxlist.com/lamictal-drug.htm#medguide
RxList. Depakote Medication Guide.
https://www.rxlist.com/depakote-drug.htm#medguide

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