Medical Editor: John P. Cunha, DO, FACOEP
What Is Lamprene?
What Are Side Effects of Lamprene?
Common side effects of Lamprene include:
- changes in skin color
- dry and scaly skin
- abdominal pain
- food intolerances
- eye irritation or burning
- eye dryness
- itchy eyes
- eye discoloration
- changes in color of urine/stool/mucus
- elevated blood sugar
Dosage for Lamprene
The recommended dosage of Lamprene is 100 mg daily. Lamprene may interact with other drugs. Tell your doctor all medications you use. Before taking Lamprene tell your doctor if you have abdominal pain, diarrhea or other stomach problems.
What Drugs, Substances, or Supplements Interact with Lamprene?
Lamprene During Pregnancy or Breastfeeding
If you are pregnant only take Lamprene if the potential benefit outweighs the potential risk to the fetus. If you are breastfeeding only take Lamprene if clearly needed.
Our Lamprene (clofazimine) Soft Gelatin Capsules Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
The following serious adverse reactions are discussed in greater detail in other sections of the labeling:
- Abdominal Obstruction and Gastrointestinal Adverse Reactions [see WARNINGS AND PRECAUTIONS]
- QT Prolongation [see WARNINGS AND PRECAUTIONS]
- Skin and Body Fluid Discoloration and Other Skin Reactions [see WARNINGS AND PRECAUTIONS]
- Psychological Effects of Skin Discoloration [see WARNINGS AND PRECAUTIONS]
The following adverse reactions associated with the use of LAMPRENE were identified. Because these adverse reactions are reported from different studies, these adverse reactions cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.
Adverse Reactions Occurring In More Than 1% of Patients
Skin: Pigmentation from pink to brownish-black in 75% to 100% of the patients within a few weeks of treatment; ichthyosis and dryness (8% to 28%); rash and pruritus (1% to 5%).
Gastrointestinal: Abdominal and epigastric pain, diarrhea, nausea, vomiting, gastrointestinal intolerance (40%-to-50%).
Ocular: Conjunctival and corneal pigmentation due to clofazimine crystal deposits; dryness; burning; itching; irritation.
Other: Discoloration of urine, feces, sputum, sweat; elevated blood sugar; elevated erythrocyte sedimentation rate (ESR).
Adverse Reactions Occurring In Less Than 1% of Patients
Skin: Phototoxicity, erythroderma, acneiform eruptions, monilial cheilosis.
Gastrointestinal: Bowel obstruction, gastrointestinal bleeding, anorexia, constipation, weight loss, hepatitis, jaundice, eosinophilic enteritis, enlarged liver.
Ocular: Diminished vision, maculopathy (bull's eye retinopathy).
Nervous: Dizziness, drowsiness, fatigue, headache, giddiness, neuralgia, taste disorder.
Psychiatric: Depression and suicide secondary to skin discoloration.
Laboratory: Elevated levels of albumin, serum bilirubin, and aspartate aminotransferase (AST); eosinophilia; hypokalemia.
Other: Splenic infarction, thromboembolism, anemia, cystitis, bone pain, edema, fever, lymphadenopathy, vascular pain.
Read the entire FDA prescribing information for Lamprene (Clofazimine)
© Lamprene Patient Information is supplied by Cerner Multum, Inc. and Lamprene Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.
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