Lanoxin Tablets Side Effects Center

Last updated on RxList: 10/13/2021
Lanoxin Tablets Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Are Lanoxin Tablets?

Lanoxin Tablets (digoxin) is a cardiac glycoside that has specific effects on the myocardial (heart muscle) tissue and is used to treat heart failure by increasing left ventricular ejection fractions and arrhythmias such as atrial fibrillation by controlling the ventricular response rate. Lanoxin is available in generic form. Most side effects and toxicity of Lanoxin Tablets are avoided if the maintenance dose (see below) is within prescribed limits.

What Are Side Effects of Lanoxin Tablets?

Side effects of Lanoxin include:

Tell your doctor if you experience unlikely but serious side effects of Lanoxin including:

  • mental/mood changes, or
  • vision changes (such as blurred or yellow/green vision).

Dosage for Lanoxin Tablets

Lanoxin Tablets are supplied as 125 or 250 mcg (microgram) once a day; adequate dosing without toxicity is determined usually by a blood test that determines the drug's level in the blood.

What Drugs, Substances, or Supplements Interact with Lanoxin Tablets?

Lanoxin Tablets may interact with antacids or Kaopectate, alprazolam, cancer medications, clonidine, supplements or medications that contain calcium, diuretics (water pills), amphotericin B, cholestyramine, epinephrine, indomethacin, isoproterenol, itraconazole, levothyroxine, metoclopramide, neomycin, rifampin, St. John's wort, sulfasalazine, antibiotics, heart or blood pressure medicines, decongestant cold or allergy medicine or nasal sprays, heart rhythm medications, or steroids. Tell your doctor all medications and supplements you use.

Lanoxin Tablets During Pregnancy or Breastfeeding

Tell your doctor if you are pregnant or plan to become pregnant while using Lanoxin Tablets; it is unknown if Lanoxin Tablets will harm a fetus. Lanoxin Tablets can pass into breast milk and may harm a nursing baby. Consult your doctor before breastfeeding.

Additional Information

Our Lanoxin Tablets Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Lanoxin Tablets Consumer Information

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Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • nausea, vomiting, diarrhea, stomach pain;
  • fast, slow, or uneven heart rate;
  • a light-headed feeling, like you might pass out;
  • bloody or black, tarry stools;
  • confusion, weakness, hallucinations, unusual thoughts or behavior;
  • breast swelling or tenderness;
  • blurred vision, yellowed vision; or
  • (in babies or children) stomach pain, weight loss, growth delay, behavior changes.

Serious side effects may be more likely in older adults and those who are ill or debilitated.

Common side effects may include:

  • nausea, diarrhea;
  • feeling weak or dizzy;
  • headache, weakness, anxiety, depression; or
  • rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Lanoxin Tablets Professional Information


The following adverse reactions are included in more detail in the WARNINGS AND PRECAUTIONS section of the label:

Clinical Trials Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice.

In general, the adverse reactions of LANOXIN are dose-dependent and occur at doses higher than those needed to achieve a therapeutic effect. Hence, adverse reactions are less common when LANOXIN is used within the recommended dose range, is maintained within the therapeutic serum concentration range, and when there is careful attention to concurrent medications and conditions.

In the DIG trial (a trial investigating the effect of digoxin on mortality and morbidity in patients with heart failure), the incidence of hospitalization for suspected digoxin toxicity was 2% in patients taking LANOXIN compared to 0.9% in patients taking placebo [see Clinical Studies].

The overall incidence of adverse reactions with digoxin has been reported as 5 to 20%, with 15 to 20% of adverse events considered serious. Cardiac toxicity accounts for about one-half, gastrointestinal disturbances for about one-fourth, and CNS and other toxicity for about one-fourth of these adverse events.

Gastrointestinal: In addition to nausea and vomiting, the use of digoxin has been associated with abdominal pain, intestinal ischemia, and hemorrhagic necrosis of the intestines.

CNS: Digoxin can cause headache, weakness, dizziness, apathy, confusion, and mental disturbances (such as anxiety, depression, delirium, and hallucination).

Other: Gynecomastia has been occasionally observed following the prolonged use of digoxin. Thrombocytopenia and maculopapular rash and other skin reactions have been rarely observed.

Read the entire FDA prescribing information for Lanoxin Tablets (Digoxin Tablets)

© Lanoxin Tablets Patient Information is supplied by Cerner Multum, Inc. and Lanoxin Tablets Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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