Leucovorin

Editor: John P. Cunha, DO, FACOEP Last updated on RxList: 10/5/2021
Leucovorin Side Effects Center

What Is Leucovorin?

Leucovorin Calcium is a form of folic acid used to reduce the side effects of large doses or accidental overdose of medications that can reduce the effects of folic acid in the body. These medications include methotrexate, pyrimethamine, trimethoprim, and others. Leucovorin Calcium is available in generic form. Many people using Leucovorin Calcium do not have serious side effects.

What Are Side Effects of Leucovorin?

Infrequent side effects of Leucovorin Calcium include:

Seek immediate medical attention if you notice symptoms of a serious allergic reaction, including rash, itching or swelling (especially of the face/tongue/throat), severe dizziness, hives, or trouble breathing.

Dosage for Leucovorin

Dosage of Leucovorin Calcium is based on the patient's medical condition and response to treatment. Doses above 25 milligrams are not recommended.

What Drugs, Substances, or Supplements Interact with Leucovorin?

Leucovorin Calcium may interact with fluorouracil, phenytoin, fosphenytoin, ethotoin, phenobarbital, or primidone. Tell your doctor all medications and supplements you use.

Leucovorin During Pregnancy or Breastfeeding

During pregnancy, Leucovorin Calcium should be used only when prescribed. It is unknown if this medication passes into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our Leucovorin Calcium Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

SLIDESHOW

Digestive Disorders: Common Misconceptions See Slideshow
Leucovorin Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Leucovorin (Leucovorin Calcium Tablets)

QUESTION

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Leucovorin Professional Information

SIDE EFFECTS

Allergic sensitization, including anaphylactoid reactions and urticaria, has been reported following the administration of both oral and parenteral leucovorin.

Read the entire FDA prescribing information for Leucovorin (Leucovorin Calcium Tablets)

© Leucovorin Patient Information is supplied by Cerner Multum, Inc. and Leucovorin Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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