Slideshows Images Quizzes


Last reviewed on RxList: 12/13/2016
Leucovorin Side Effects Center

Last reviewed on RxList 12/19/2015

Leucovorin Calcium is a form of folic acid used to reduce the side effects of large doses or accidental overdose of medications that can reduce the effects of folic acid in the body. These medications include methotrexate, pyrimethamine, trimethoprim, and others. Leucovorin Calcium is available in generic form. Many people using Leucovorin Calcium do not have serious side effects. Infrequent side effects of Leucovorin Calcium include facial flushing, nausea, and vomiting. Seek immediate medical attention if you notice symptoms of a serious allergic reaction, including rash, itching or swelling (especially of the face/tongue/throat), severe dizziness, hives, or trouble breathing.

Dosage of Leucovorin Calcium is based on the patient's medical condition and response to treatment. Doses above 25 milligrams are not recommended. Leucovorin Calcium may interact with fluorouracil, phenytoin, fosphenytoin, ethotoin, phenobarbital, or primidone. Tell your doctor all medications and supplements you use. During pregnancy, Leucovorin Calcium should be used only when prescribed. It is unknown if this medication passes into breast milk. Consult your doctor before breastfeeding.

Our Leucovorin Calcium Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Leucovorin Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Leucovorin (Leucovorin Calcium Tablets)

Leucovorin Professional Information


Allergic sensitization, including anaphylactoid reactions and urticaria, has been reported following the administration of both oral and parenteral leucovorin.

Read the entire FDA prescribing information for Leucovorin (Leucovorin Calcium Tablets)

Related Resources for Leucovorin

Read the Leucovorin User Reviews »

© Leucovorin Patient Information is supplied by Cerner Multum, Inc. and Leucovorin Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

Health Solutions From Our Sponsors