Leukeran Side Effects Center

Last updated on RxList: 7/6/2022
Leukeran Side Effects Center

What Is Leukeran?

Leukeran (chlorambucil) Tablets is an anticancer drug used to treat several types of cancer including Hodgkin's disease, leukemia, and lymphoma.

What Are Side Effects of Leukeran?

Common side effects of Leukeran include:

  • nausea,
  • vomiting,
  • diarrhea,
  • tremors or shaking,
  • numbness,
  • burning, pain, and
  • tingling feeling

Tell your doctor if you experience serious side effects of Leukeran including seizures (convulsions); fever, chills, body aches, flu symptoms, sores in your mouth and throat, pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating; easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin; sore throat, and headache with a severe blistering, peeling, and red skin rash; itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); an unusual mass or lump; chest discomfort, dry cough or hack, persistent cough; shortness of breath on exertion; weakness or tiredness, rapid weight loss; severe nausea, vomiting, or diarrhea; or missed menstrual periods.

Seek medical care or call 911 at once if you have the following serious side effects:

  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheartedness, or passing out;
  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

Dosage for Leukeran

The usual dosage of Leukeran is 0.1 to 0.2 mg/kg body weight daily for 3 to 6 weeks. Talk to your doctor about your individual dosage recommendation.

What Drugs, Substances, or Supplements Interact with Leukeran?

There may be other drugs that interact with Leukeran. Tell your doctor all medications you use. Leukeran may lower your body's immune system.

Leukeran During Pregnancy and Breastfeeding

It may also cause infertility in men and women. Do not take Leukeran if you are pregnant or breastfeeding.

Leukeran During Pregnancy and Breastfeeding

Additional Information

Our Leukeran (chlorambucil) Tablets Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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Leukeran Consumer Information

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Call your doctor at once if you have:

  • a seizure;
  • an unusual mass or lump;
  • severe vomiting or diarrhea;
  • new or worsening cough;
  • bone marrow suppression--dizziness, pale lips or fingernail beds, fast heart rate, getting easily tired or short of breath;
  • liver problems--loss of appetite, stomach pain (upper right side), dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
  • low blood cell counts--fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath.

Common side effects may include:

  • bone marrow suppression;
  • low blood cell counts;
  • missed menstrual periods;
  • nausea, vomiting, diarrhea; or
  • sores or white patches in or around your mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Leukeran Professional Information

SIDE EFFECTS

To report SUSPECTED ADVERSE REACTIONS, contact Aspen Global Inc. Toll-Free at 1-855-800-8165 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Hematologic

The most common side effect is bone marrow suppression, anemia, leukopenia, neutropenia, thrombocytopenia, or pancytopenia. Although bone marrow suppression frequently occurs, it is usually reversible if the chlorambucil is withdrawn early enough. However, irreversible bone marrow failure has been reported.

Gastrointestinal

Gastrointestinal disturbances such as nausea and vomiting, diarrhea, and oral ulceration occur infrequently.

CNS

Tremors, muscular twitching, myoclonia, confusion, agitation, ataxia, flaccid paresis, and hallucinations have been reported as rare adverse experiences to chlorambucil which resolve upon discontinuation of drug. Rare, focal and/or generalized seizures have been reported to occur in both children and adults at both therapeutic daily doses and pulsedosing regimens, and in acute overdose (see PRECAUTIONS: General).

Dermatologic

Allergic reactions such as urticaria and angioneurotic edema have been reported following initial or subsequent dosing. Skin hypersensitivity (including rare reports of skin rash progressing to erythema multiforme, toxic epidermal necrolysis, and Stevens-Johnson syndrome) has been reported (see WARNINGS).

Miscellaneous

Other reported adverse reactions include: pulmonary fibrosis, hepatotoxicity and jaundice, drug fever, peripheral neuropathy, interstitial pneumonia, sterile cystitis, infertility, leukemia, and secondary malignancies (see WARNINGS).

DRUG INTERACTIONS

There are no known drug/drug interactions with chlorambucil.

Read the entire FDA prescribing information for Leukeran (Chlorambucil)

© Leukeran Patient Information is supplied by Cerner Multum, Inc. and Leukeran Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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