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Leukeran

Last reviewed on RxList: 9/25/2018
Leukeran Side Effects Center

Last reviewed on RxList 9/25/2018

Leukeran (chlorambucil) Tablets is an anticancer drug used to treat several types of cancer including Hodgkin's disease, leukemia, and lymphoma. Common side effects of Leukeran include:

  • nausea,
  • vomiting,
  • diarrhea,
  • tremors or shaking,
  • numbness,
  • burning, pain, and
  • tingling feeling

Tell your doctor if you experience serious side effects of Leukeran including seizures (convulsions); fever, chills, body aches, flu symptoms, sores in your mouth and throat, pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating; easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin; sore throat, and headache with a severe blistering, peeling, and red skin rash; itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); an unusual mass or lump; chest discomfort, dry cough or hack, persistent cough; shortness of breath on exertion; weakness or tiredness, rapid weight loss; severe nausea, vomiting, or diarrhea; or missed menstrual periods.

The usual dosage of Leukeran is 0.1 to 0.2 mg/kg body weight daily for 3 to 6 weeks. Talk to your doctor about your individual dosage recommendation. There may be other drugs that interact with Leukeran. Tell your doctor all medications you use. Leukeran may lower your body's immune system. It may also cause infertility in men and women. Do not take Leukeran if you are pregnant or breastfeeding.

Our Leukeran (chlorambucil) Tablets Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Leukeran Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • seizure (convulsions);
  • an unusual mass or lump;
  • severe vomiting or diarrhea;
  • new or worsening cough;
  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
  • liver problems--nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • low white blood cell counts--fever, swollen gums, painful mouth sores, pain when swallowing, skin sores, cold or flu symptoms, cough, trouble breathing; or
  • severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Common side effects may include:

  • bone marrow suppression (fever, bleeding, flu symptoms).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Leukeran (Chlorambucil)

Leukeran Professional Information

SIDE EFFECTS

Hematologic

The most common side effect is bone marrow suppression, anemia, leukopenia, neutropenia, thrombocytopenia, or pancytopenia. Although bone marrow suppression frequently occurs, it is usually reversible if the chlorambucil is withdrawn early enough. However, irreversible bone marrow failure has been reported.

Gastrointestinal

Gastrointestinal disturbances such as nausea and vomiting, diarrhea, and oral ulceration occur infrequently.

CNS4

Tremors, muscular twitching, myoclonia, confusion, agitation, ataxia, flaccid paresis, and hallucinations have been reported as rare adverse experiences to chlorambucil which resolve upon discontinuation of drug. Rare, focal and/or generalized seizures have been reported to occur in both children and adults at both therapeutic daily doses and pulse-dosing regimens, and in acute overdose (see PRECAUTIONS: General).

Dermatologic

Allergic reactions such as urticaria and angioneurotic edema have been reported following initial or subsequent dosing. Skin hypersensitivity (including rare reports of skin rash progressing to erythema multiforme, toxic epidermal necrolysis, and Stevens-Johnson syndrome) has been reported (see WARNINGS).

Miscellaneous

Other reported adverse reactions include: pulmonary fibrosis, hepatotoxicity and jaundice, drug fever, peripheral neuropathy, interstitial pneumonia, sterile cystitis, infertility, leukemia, and secondary malignancies (see WARNINGS).

Read the entire FDA prescribing information for Leukeran (Chlorambucil)

Related Resources for Leukeran

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Read the Leukeran User Reviews »

© Leukeran Patient Information is supplied by Cerner Multum, Inc. and Leukeran Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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