Levophed Side Effects Center

Last updated on RxList: 3/4/2021
Levophed Side Effects Center

What Is Levophed?

Levophed (norepinephrine bitartrate) is a vasoconstrictor, similar to adrenaline, used to treat life-threatening low blood pressure (hypotension) that can occur with certain medical conditions or surgical procedures. Levophed is often used during or after CPR (cardio-pulmonary resuscitation). Levophed is available in generic form.

What Are Side Effects of Levophed?

Tell your doctor if you have serious side effects of Levophed include:

  • dizziness,
  • weakness,
  • headache,
  • slow heart rate,
  • breathing difficulty, or
  • redness and swelling at the injection site.

Serious side effects of Levophed include:

  • pain or burning where the injection is given,
  • sudden numbness/weakness/cold feeling in your body,
  • blue lips or fingernails,
  • urinating less than usual or not at all,
  • trouble breathing,
  • dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, irregular heartbeats, seizure).

Dosage for Levophed

Levophed is diluted in liquid and given continuously into a large vein (IV infusion), as directed by the doctor. Dosage is based on the patient's condition and response to treatment.

What Drugs, Substances, or Supplements Interact with Levophed?

Levophed may interact with blood pressure medications, MAO inhibitors, or antidepressants. Tell your doctor all medications you use.

Levophed During Pregnancy and Breastfeeding

During pregnancy, Levophed should be used only if prescribed. It is unknown if this medication passes into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our Levophed (norepinephrine bitartrate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Low Blood Pressure (Hypotension): Symptoms, Signs, Causes See Slideshow
Levophed Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers at once if you have:

  • pain, burning, irritation, discoloration, or skin changes where the injection was given;
  • sudden numbness, weakness, or cold feeling anywhere in your body;
  • slow or uneven heart rate;
  • blue lips or fingernails, mottled skin;
  • little or no urination;
  • trouble breathing;
  • problems with vision, speech, or balance; or
  • severe headache, blurred vision, pounding in your neck or ears.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Levophed (Norepinephrine Bitartrate)

Levophed Professional Information


The following adverse reactions are described in greater detail in other sections:

  • Tissue Ischemia [see WARNINGS AND PRECAUTIONS]
  • Hypotension [see WARNINGS AND PRECAUTIONS]
  • Cardiac Arrhythmias [see WARNINGS AND PRECAUTIONS]

The most common adverse reactions are hypertension and bradycardia.

The following adverse reactions can occur:

Nervous system disorders: Anxiety, headache

Respiratory disorders: Respiratory difficulty, pulmonary edema

Read the entire FDA prescribing information for Levophed (Norepinephrine Bitartrate)

© Levophed Patient Information is supplied by Cerner Multum, Inc. and Levophed Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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