Librax

Last updated on RxList: 2/22/2021
Librax Side Effects Center

What Is Librax?

Librax (chlordiazepoxide and clidinium bromide) is a combination of a benzodiazepine and an anticholinergic/spasmolytic used to treat stomach ulcers, irritable bowel syndrome, and intestinal infections. The brand name Librax is no longer available in the U.S. Generic versions may be available.

What Are Side Effects of Librax?

Common side effects of Librax (chlordiazepoxide and clidinium bromide) include:

Tell your doctor if you have unlikely but serious side effects of Librax (chlordiazepoxide and clidinium bromide) including:

  • decreased sweating,
  • dry/hot/flushed skin,
  • fast or irregular heartbeat,
  • loss of coordination,
  • slurred speech,
  • fainting,
  • uncontrollable or unusual muscle movements,
  • mental/mood changes (such as confusion, agitation, unusual excitement, depression, or strange thoughts),
  • difficulty urinating,
  • decreased sexual ability, or
  • slow or shallow breathing.

Dosage for Librax

The dosage of chlordiazepoxide and clidinium varies with the diagnosis and response of the individual patient. The usual maintenance dose is 1 or 2 capsules (5 mg chlordiazepoxide hydrochloride and 2.5 mg clidinium bromide), 3 or 4 times a day administered before meals and at bedtime.

What Drugs, Substances, or Supplements Interact with Librax?

Chlordiazepoxide and clidinium may interact with barbiturates, blood thinners, MAO inhibitors, medicines to treat psychiatric disorders, narcotics, or antidepressants. Tell your doctor all medications you use.

Librax During Pregnancy and Breastfeeding

Chlordiazepoxide and clidinium is not recommended for use during pregnancy. It may harm a fetus. This medication passes into breast milk and may have undesirable effects on a nursing infant. Breastfeeding while using this drug is not recommended. This medication may be habit-forming. Withdrawal symptoms may occur if this drug is stopped abruptly.

Additional Information

Our Librax (chlordiazepoxide HCI clidinium bromide) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

SLIDESHOW

Digestive Disorders: Common Misconceptions See Slideshow
Librax Consumer Information

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Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

This medicine can slow or stop your breathing, especially if you have recently used an opioid medication, alcohol, or other drugs that can slow your breathing. A person caring for you should seek emergency medical attention if you have weak or shallow breathing, if you are hard to wake up, or if you stop breathing.

Call your doctor at once if you have:

  • severe drowsiness;
  • a light-headed feeling, like you might pass out;
  • problems with balance or coordination;
  • confusion, excitement, anger, or feeling restless;
  • severe constipation;
  • painful or difficult urination;
  • restless muscle movements in your eyes, tongue, jaw, or neck;
  • fever, chills, sore throat; or
  • jaundice (yellowing of the skin or eyes).

The sedative effects of this medicine may last longer in older adults. Accidental falls are common in elderly patients who take benzodiazepines. Use caution to avoid falling or accidental injury.

Common side effects may include:

  • dry mouth;
  • blurred vision;
  • constipation, nausea;
  • urination problems;
  • drowsiness, dizziness;
  • rash;
  • swelling;
  • irregular menstrual periods; or
  • increased or decreased interest in sex.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Librax (Chlordiazepoxide and Clidinium)

QUESTION

What is irritable bowel syndrome or IBS? See Answer
Librax Professional Information

SIDE EFFECTS

No side effects or manifestations not seen with either compound alone have been reported with the administration of Librax. However, since Librax contains chlordiazepoxide hydrochloride and clidinium bromide, the possibility of untoward effects which may be seen with either of these two compounds cannot be excluded.

When chlordiazepoxide hydrochloride has been used alone the necessity of discontinuing therapy because of undesirable effects has been rare. Drowsiness, ataxia and confusion have been reported in some patients — particularly the elderly and debilitated. While these effects can be avoided in almost all instances by proper dosage adjustment, they have occasionally been observed at the lower dosage ranges. In a few instances syncope has been reported.

Other adverse reactions reported during therapy with chlordiazepoxide hydrochloride include isolated instances of skin eruptions, edema, minor menstrual irregularities, nausea and constipation, extrapyramidal symptoms, as well as increased and decreased libido. Such side effects have been infrequent and are generally controlled with reduction of dosage. Changes in EEG patterns (low-voltage fast activity) have been observed in patients during and after chlordiazepoxide hydrochloride treatment.

Blood dyscrasias, including agranulocytosis, jaundice and hepatic dysfunction have occasionally been reported during therapy with chlordiazepoxide hydrochloride. When chlordiazepoxide hydrochloride treatment is protracted, periodic blood counts and liver function tests are advisable.

Adverse effects reported with use of Librax are those typical of anticholinergic agents, i.e., dryness of the mouth, blurring of vision, urinary hesitancy and constipation. Constipation has occurred most often when Librax therapy has been combined with other spasmolytic agents and/or a low residue diet.

To report SUSPECTED ADVERSE REACTIONS, contact Bausch Health US, LLC at 1-800-3214576 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Read the entire FDA prescribing information for Librax (Chlordiazepoxide and Clidinium)

© Librax Patient Information is supplied by Cerner Multum, Inc. and Librax Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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