Limbitrol Side Effects Center

Last updated on RxList: 8/31/2022
Limbitrol Side Effects Center

What Is Limbitrol?

Limbitrol (chlordiazepoxide amitriptyline ds tablets) is a combination of a benzodiazepine and a tricyclic antidepressant used to treat depression, anxiety, and tension.

What Are Side Effects of Limbitrol?

Common side effects of Limbitrol include:

  • dry mouth,
  • dizziness,
  • drowsiness,
  • restlessness,
  • tiredness,
  • constipation,
  • loss of appetite,
  • bloating,
  • strange dreams or nightmares,
  • stuffy nose,
  • blurred vision,
  • decreased sex drive,
  • impotence, or
  • difficulty having an orgasm

Limbitrol may cause serious side effects including:

  • hives,
  • difficulty breathing,
  • swelling of your face, lips, tongue, or throat,
  • weak or shallow breathing,
  • difficulty to wake up,
  • breathing that stops,
  • mood or behavior changes,
  • anxiety,
  • panic attacks,
  • trouble sleeping,
  • impulsive behavior,
  • irritableness,
  • agitation,
  • hostility,
  • aggression,
  • restlessness,
  • hyperactivity (mentally or physically),
  • increased depression,
  • thoughts of self-harm,
  • severe constipation,
  • confusion,
  • hallucinations,
  • unusual thoughts or behavior,
  • chest pain or pressure,
  • pain spreading to the jaw or shoulder,
  • pounding heartbeats,
  • fluttering in your chest,
  • lightheadedness,
  • little or no urination

Get medical help right away, if you have any of the symptoms listed above.

Seek medical care or call 911 at once if you have the following serious side effects:

  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheartedness, or passing out;
  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

Dosage for Limbitrol

Limbitrol is taken by mouth 1 to 4 times daily or as directed by your doctor.

What Drugs, Substances, or Supplements Interact with Limbitrol?

Limbitrol may interact with other medications, including antiplatelet drugs (clopidogrel, NSAIDs such as ibuprofen, "blood thinners" such as warfarin), drugs for high blood pressure (clonidine, guanabenz, reserpine), bronchodilators/decongestants/stimulants, celecoxib (Celebrex), cimetidine (Tagamet), ADHD medications (Adderall, Ritalin, Strattera), cancer medications, heart rhythm medications, HIV medications, medicine to treat or prevent nausea and vomiting, medicine to treat psychiatric disorders, narcotics, or thyroid supplements. Tell your doctor all medications you take.

Limbitrol During Pregnancy and Breastfeeding

If you are pregnant or think you may be pregnant, discuss with your doctor the benefits and risks of using this medication. This medication passes into breast milk. Consult your doctor before breastfeeding.

Our Limbitrol (chlordiazepoxide amitriptyline ds tablets) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

Additional Information

Our Limbitrol (chlordiazepoxide amitriptyline ds tablets) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Limbitrol Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Amitriptyline and chlordiazepoxide can slow or stop your breathing, especially if you have recently used an opioid medication, alcohol, or other drugs that can slow your breathing. A person caring for you should seek emergency medical attention if you have weak or shallow breathing, if you are hard to wake up, or if you stop breathing.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have:

  • severe constipation;
  • confusion, hallucinations, unusual thoughts or behavior;
  • chest pain or heavy feeling, pain spreading to the jaw or shoulder;
  • pounding heartbeats or fluttering in your chest;
  • a light-headed feeling, like you might pass out; or
  • little or no urination.

The sedative effects of this medicine may last longer in older adults. Accidental falls are common in elderly patients who take benzodiazepines. Use caution to avoid falling or accidental injury.

Common side effects may include:

  • dizziness, drowsiness;
  • blurred vision;
  • dry mouth; or
  • constipation, bloating.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Limbitrol Professional Information


Adverse reactions to LIMBITROL are those associated with the use of either component alone. Most frequently reported were drowsiness, dry mouth, constipation, blurred vision, dizziness and bloating. Other side effects occurring less commonly included vivid dreams, impotence, tremor, confusion and nasal congestion. Many symptoms common to the depressive state, such as anorexia, fatigue, weakness, restlessness and lethargy, have been reported as side effects of treatment with both LIMBITROL and amitriptyline.

Granulocytopenia, jaundice and hepatic dysfunction of uncertain etiology have also been observed rarely with LIMBITROL. When treatment with LIMBITROL is prolonged, periodic blood counts and liver function tests are advisable.

Note: Included in the listing which follows are adverse reactions which have not been reported with LIMBITROL. However, they are included because they have been reported during therapy with one or both of the components or closely related drugs.


Hypotension, hypertension, tachycardia, palpitations, myocardial infarction, arrhythmias, heart block, stroke.


Euphoria, apprehension, poor concentration, delusions, hallucinations, hypomania and increased or decreased libido.


Incoordination, ataxia, numbness, tingling and paresthesias of the extremities, extrapyramidal symptoms, syncope, changes in EEG patterns.


Disturbance of accommodation, paralytic ileus, urinary retention, dilatation of urinary tract.


Skin rash, urticaria, photosensitization, edema of face and tongue, pruritus.


Bone marrow depression including agranulocytosis, eosinophilia, purpura, thrombocytopenia.


Nausea, epigastric distress, vomiting, anorexia, stomatitis, peculiar taste, diarrhea, black tongue.


Testicular swelling and gynecomastia in the male, breast enlargement, galactorrhea and minor menstrual irregularities in the female, elevation and lowering of blood sugar levels, and syndrome of inappropriate ADH (antidiuretic hormone) secretion.


Headache, weight gain or loss, increased perspiration, urinary frequency, mydriasis, jaundice, alopecia, parotid swelling.

Read the entire FDA prescribing information for Limbitrol (Chlordiazepoxide Amitriptyline DS Tablets)

© Limbitrol Patient Information is supplied by Cerner Multum, Inc. and Limbitrol Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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