Linzess vs. Kristalose

Are Linzess and Kristalose the Same Thing?

Linzess (linaclotide) and Kristalose (lactulose) are used to treat forms of constipation.

Linzess is specifically used to treat irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC) in adults.

Linzess and Kristalose belong to different drug classes. Linzess is a guanylate cyclase-C agonist and Kristalose is a synthetic disaccharide.

What Are Possible Side Effects of Linzess?

Common side effects of Linzess include:

What Are Possible Side Effects of Kristalose?

Common side effects of Kristalose include:

What is Linzess?

Linzess (linaclotide) is a guanylate cyclase-C agonist used to treat irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC) in adults.

What is Kristalose?

Kristalose (lactulose) For Oral Solution is a synthetic disaccharide indicated for the treatment of constipation.


You are constipated if you don't have a bowel movement every day. See Answer

What Drugs Interact With Linzess?

Linzess may interact with other drugs.

What Drugs Interact With Kristalose?

Kristalose may interact with antacids. Tell your doctor all medications and supplements you use.

How Should Linzess Be Taken?

The recommended dose of Linzess for those with irritable bowel syndrome (IBS) is 290 mcg taken once a day on an empty stomach, at least 30 minutes before the first meal of the day. The same applies for those with chronic idiopathic constipation only the dosage is 145 mcg. Pediatric patients under the age of 17 should not take Linzess.

How Should Kristalose Be Taken?

The usual adult dosage of Kristalose is 10 g to 20 g of lactulose daily. The dose of Kristalose may be increased to 40 g daily if necessary. Twenty-four to 48 hours may be required to produce a normal bowel movement.


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Allergan/Ironwood. Linzess Product Information.
Cumberland Pharmaceuticals Inc. Kristalose Product Information.

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