Linzess vs. Motegrity

Are Linzess and Motegrity the Same Thing?

Linzess (linaclotide) and Motegrity (prucalopride) are used in adults to treat chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C).

Motegrity may be used off-label to treat irritable bowel syndrome with constipation (IBS-C).

Linzess and Motegrity belong to different drug classes. Linzess is a guanylate cyclase-C agonist and Motegrity is a serotonin-4 (5-HT4) receptor agonist.

Side effects of Linzess and Motegrity that are similar include diarrhea, stomach/abdominal pain or discomfort, gas, bloating, vomiting, and headache.

Side effects of Linzess that are different from Motegrity include heartburn, and cold symptoms such as stuffy nose, sneezing, or sinus pain.

Side effects of Motegrity that are different from Linzess include nausea, dizziness, and fatigue.

Linzess may interact with other drugs.

Motegrity may interact with erythromycin and ketoconazole.

What Are Possible Side Effects of Linzess?

Common side effects of Linzess include:

  • diarrhea,
  • stomach/abdominal pain or discomfort,
  • gas,
  • bloating,
  • heartburn,
  • vomiting,
  • headache, or
  • cold symptoms such as stuffy nose, sneezing, or sinus pain.

What Are Possible Side Effects of Motegrity?

Common side effects of Motegrity include:

  • headache,
  • abdominal pain,
  • nausea,
  • diarrhea,
  • bloating,
  • dizziness,
  • vomiting,
  • gas (flatulence), and
  • fatigue

What Is Linzess?

Linzess (linaclotide) is a guanylate cyclase-C agonist used to treat irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC) in adults.

What Is Motegrity?

Motegrity (prucalopride) is a serotonin-4 (5-HT4) receptor agonist indicated for the treatment of chronic idiopathic constipation (CIC) in adults.

SLIDESHOW

Super Tips to Boost Digestive Health: Bloating, Constipation, and More See Slideshow

What Drugs Interact With Linzess?

Linzess may interact with other drugs.

What Drugs Interact With Motegrity?

Motegrity may interact with erythromycin or ketoconazole. Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plan to become pregnant before using Motegrity; it is unknown how it would affect a fetus. Motegrity passes into breast milk. Consult your doctor before breastfeeding.

How Should Linzess Be Taken?

The recommended dose of Linzess for those with irritable bowel syndrome (IBS) is 290 mcg taken once a day on an empty stomach, at least 30 minutes before the first meal of the day. The same applies for those with chronic idiopathic constipation only the dosage is 145 mcg. Pediatric patients under the age of 17 should not take Linzess.

How Should Motegrity Be Taken?

The recommended dose of Motegrity is 2 mg once daily.

QUESTION

Pancreatitis is inflammation of an organ in the abdomen called the pancreas. See Answer
Disclaimer

All drug information provided on RxList.com is sourced directly from drug monographs published by the U.S. Food and Drug Administration (FDA).

Any drug information published on RxList.com regarding general drug information, drug side effects, drug usage, dosage, and more are sourced from the original drug documentation found in its FDA drug monograph.

Drug information found in the drug comparisons published on RxList.com is primarily sourced from the FDA drug information. The drug comparison information found in this article does not contain any data from clinical trials with human participants or animals performed by any of the drug manufacturers comparing the drugs.

The drug comparisons information provided does not cover every potential use, warning, drug interaction, side effect, or adverse or allergic reaction. RxList.com assumes no responsibility for any healthcare administered to a person based on the information found on this site.

As drug information can and will change at any time, RxList.com makes every effort to update its drug information. Due to the time-sensitive nature of drug information, RxList.com makes no guarantees that the information provided is the most current.

Any missing drug warnings or information does not in any way guarantee the safety, effectiveness, or the lack of adverse effects of any drug. The drug information provided is intended for reference only and should not be used as a substitute for medical advice.

If you have specific questions regarding a drug’s safety, side effects, usage, warnings, etc., you should contact your doctor or pharmacist, or refer to the individual drug monograph details found on the FDA.gov or RxList.com websites for more information.

You may also report negative side effects of prescription drugs to the FDA by visiting the FDA MedWatch website or calling 1-800-FDA-1088.

References

Allergan/Ironwood. Linzess Product Information.
https://www.linzess.com
Takeda Pharmaceutical. Motegrity Product Information.
https://www.motegrityhcp.com

Health Solutions From Our Sponsors