Linzess vs. Trulance

Are Linzess and Trulance the Same Thing?

Linzess (linaclotide) and Trulance (plecanatide) are guanylate cyclase-C agonists used to treat chronic idiopathic constipation (CIC) in adults.

Linzess is also used to treat irritable bowel syndrome with constipation (IBS-C).

What Are Possible Side Effects of Linzess?

Common side effects of Linzess include:

What Are Possible Side Effects of Trulance?

Common side effects of Trulance include:

What is Linzess?

Linzess (linaclotide) is a guanylate cyclase-C agonist used to treat irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC) in adults.

What is Trulance?

Trulance (plecanatide) tablets, for oral use is a guanylate cyclase-C agonist indicated in adults for treatment of chronic idiopathic constipation (CIC).


What is irritable bowel syndrome or IBS? See Answer

What Drugs Interact With Linzess?

Linzess may interact with other drugs.

What Drugs Interact With Trulance?

Trulance may interact with other drugs.

How Should Linzess Be Taken?

The recommended dose of Linzess for those with irritable bowel syndrome (IBS) is 290 mcg taken once a day on an empty stomach, at least 30 minutes before the first meal of the day. The same applies for those with chronic idiopathic constipation only the dosage is 145 mcg. Pediatric patients under the age of 17 should not take Linzess.

How Should Trulance Be Taken?

The recommended adult dosage of Trulance is 3 mg taken orally once daily.


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Allergan/Ironwood. Linzess Product Information.
Synergy Pharmaceuticals Inc. Trulance Product Information.

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