Linzess vs. Viberzi

Are Linzess and Viberzi the Same Thing?

Linzess (linaclotide) and Viberzi (eluxadoline) are used to treat different forms of irritable bowel syndrome. Linzess is used to treat irritable bowel syndrome with constipation (IBS-C) and

Viberzi is used to treat irritable bowel syndrome with diarrhea (IBS-D).

Linzess is also used to treat chronic idiopathic constipation (CIC) in adults.

Linzess is a guanylate cyclase-C agonist and Viberzi is a mu-opioid receptor agonist.

What Are Possible Side Effects of Linzess?

Common side effects of Linzess include:

What Are Possible Side Effects of Viberzi?

Common side effects of Viberzi include:

What Is Linzess?

Linzess (linaclotide) is a guanylate cyclase-C agonist used to treat irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC) in adults.

What Is Viberzi?

Viberzi (eluxadoline) is a mu-opioid receptor agonist used in adults to treat irritable bowel syndrome with diarrhea (IBS-D).


What is irritable bowel syndrome or IBS? See Answer

What Drugs Interact With Linzess?

Linzess may interact with other drugs.

What Drugs Interact With Viberzi?

Viberzi may interact with other irritable bowel medications, narcotic pain medicines, or heart rhythm medications.

Viberzi may also interact with cyclosporine, gemfibrozil, antiretrovirals, rifampin, eltrombopag, ciprofloxacin, fluconazole, clarithromycin, paroxetine, bupropion, anticholinergics, opioids, rosuvastatin, dihydroergotamine, ergotamine, pimozide, sirolimus, or tacrolimus.

How Should Linzess Be Taken?

The recommended dose of Linzess for those with irritable bowel syndrome (IBS) is 290 mcg taken once a day on an empty stomach, at least 30 minutes before the first meal of the day. The same applies for those with chronic idiopathic constipation only the dosage is 145 mcg. Pediatric patients under the age of 17 should not take Linzess.

How Should Viberzi Be Taken?

The recommended dosage of Viberzi in adults is 100 mg twice daily, taken with food.


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Allergan/Ironwood. Linzess Product Information.
Allergan. Viberzi Product Information.

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