Lipasa, Triacylglycerol Lipase.
Lipase is a digestive enzyme that is found in many plants, animals, bacteria, and molds. An enzyme is a protein that speeds up a particular biochemical reaction in the body. People use lipase as a medicine.
Lipase is used for indigestion, heartburn, allergy to gluten in wheat products (celiac disease), Crohn's disease, and cystic fibrosis.
How does it work?
Lipase seems to work by breaking down fat into smaller pieces, making digestion easier.
- Digestion problems due to a disorder of the pancreas (pancreatic insufficiency) that is associated with cystic fibrosis.
Insufficient Evidence to Rate Effectiveness for...
- Allergy to gluten in wheat products (celiac disease).
- Crohn's disease.
- Other conditions.
Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).
The following doses have been studied in scientific research:
- For digestion problems due to a disorder of the pancreas (pancreatic insufficiency) that is associated with cystic fibrosis: A typical dose for adults is 4500 units per kilogram of lipase per day. For children, a typical dose is 5100 units per kilogram per day. Start with a low dose and gradually increase until there is a benefit, but don't take more than the typical dose without checking with your healthcare provider.
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Croft NM, Marshall TG, Ferguson A. Gut inflammation in children with cystic fibrosis on high-dose enzyme supplements. Lancet 1995;346:1265-7. View abstract.
Lloyd-Still JD. Cystic fibrosis and colonic strictures. A new "iatrogenic" disease. J Clin Gastroenterol 1995;21:2-5. View abstract.
Owen G, Peters TJ, Dawson S, Goodchild MC. Pancreatic enzyme supplement dosage in cystic fibrosis. Lancet 1991;338:1153.
Smyth RL, Ashby D, O'Hea U, et al. Fibrosing colonopathy in cystic fibrosis: results of a case-control study. Lancet 1995;346:1247-51. View abstract.
Smyth RL, van Velzen D, Smyth AR, et al. Strictures of ascending colon in cystic fibrosis and high-strength pancreatic enzymes. Lancet 1994;343:85-6. View abstract.
Stern RC, Eisenberg JD, Wagener JS, et al. A comparison of the efficacy and tolerance of pancrelipase and placebo in the treatment of steatorrhea in cystic fibrosis patients with clinical exocrine pancreatic insufficiency. Am J Gastroenterol 2000;95:1932-8. View abstract.
Thomson M, Clague A, Cleghorn GJ, Shepherd RW. Comparative in vitro and in vivo studies of enteric-coated pancrelipase preparations for pancreatic insufficiency. J Pediatr Gastroenterol Nutr 1993;17:407-13. View abstract.
Tursi JM, Phair PG, Barnes GL. Plant sources of acid stable lipases: potential therapy for cystic fibrosis. J Paediatr Child Health 1994;30:539-43. View abstract.