Lipiodol

Medical Editor: John P. Cunha, DO, FACOEP Last updated on RxList: 4/27/2022
Lipiodol Side Effects Center

What Is Lipiodol?

Lipiodol (ethiodized oil) Injection is a radio-opaque contrast agent used for hysterosalpingography in adults, lymphography in adult and pediatric patients, and selective hepatic intra-arterial use for imaging tumors in adults with known hepatocellular carcinoma (HCC).

What Are Side Effects of Lipiodol?

Common side effects of Lipiodol include:

Dosage for Lipiodol

Dosing of Lipiodol depends on the procedure being performed.

What Drugs, Substances, or Supplements Interact with Lipiodol?

Lipiodol may interact with iodine 131 treatment, and it may interfere with thyroid function tests for up to two years following administration. Tell your doctor all medications and supplements you use.

Lipiodol During Pregnancy and Breastfeeding

During pregnancy, Lipiodol should be used only if prescribed. This drug passes into breast milk. Because of risk of hypothyroidism in nursing infants, Lipiodol is not recommended for use while breastfeeding.

Additional Information

Our Lipiodol (ethiodized oil) Injection Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

SLIDESHOW

Digestive Disorders: Common Misconceptions See Slideshow
Lipiodol Professional Information

SIDE EFFECTS

Postmarketing Experience

The following adverse reactions (Table 1) have been identified during post approval use of Lipiodol. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

The following adverse reactions are described in more detail in other sections of the prescribing information:

  • Pulmonary and cerebral embolism [see WARNINGS AND PRECAUTIONS]
  • Hypersensitivity reactions [see WARNINGS AND PRECAUTIONS]
  • Exacerbation of chronic liver disease [see WARNINGS AND PRECAUTIONS]

Table 1: Adverse Reactions in the Postmarketing Experience

System Organ ClassAdverse Reaction
Endocrine disordershypothyroidism, hyperthyroidism, thyroiditis
Eye disordersretinal vein thrombosis
Gastrointestinal disordersnausea, vomiting, diarrhea
General disorders and administration site conditionsfever, pain, granuloma
Hepatobiliary disordershepatic vein thrombosis
Immune system disordershypersensitivity, anaphylactic reaction, anaphylactoid reaction
Nervous system disorderscerebral embolism
Respiratory, thoracic and mediastinal disorderspulmonary embolism, dyspnea, cough, acute respiratory distress syndrome
Urinary system disordersrenal insufficiency

Hysterosalpingography

Abdominal pain, foreign body reactions, exacerbation of pelvic inflammatory disease.

Lymphography

Cardiovascular collapse, lymphangitis, thrombophlebitis, edema or exacerbation of preexisting lymphedema, dyspnea and cough, fever, iodism (headache, soreness of mouth and pharynx, coryza and skin rash), allergic dermatitis, lipogranuloma, delayed healing at the site of incision.

Selective Hepatic Intra-arterial Injection

Fever, abdominal pain, nausea, and vomiting are the most common reactions; other reactions include hepatic ischemia, liver enzymes abnormalities, transitory decrease in liver function, liver decompensation and renal insufficiency. Procedural risks include vascular complications and infections.

Read the entire FDA prescribing information for Lipiodol (Ethiodized Oil Injection)

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© Lipiodol Patient Information is supplied by Cerner Multum, Inc. and Lipiodol Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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