Lipodox

Last updated on RxList: 8/2/2018
Lipodox Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 8/2/2018

Lipodox (doxorubicin hydrochloride injectable, liposomal) is a cytotoxic anthracycline antibiotic (an anti-cancer drug) indicated for the treatment of metastatic carcinoma of the ovary in patients with disease that is refractory to both paclitaxel and platinum based chemotherapy regimens; as monotherapy for the treatment of metastatic breast cancer, where there is an increased cardiac risk; and for the treatment of AIDS related Kaposi's Sarcoma in patients with extensive mucocutaneous or visceral disease that has progressed on prior combination therapy (consisting of two of the following agents: a vinca alkaloid, bleomycin and standard doxorubicin or another anthracycline) or in patients who are intolerant to such therapy. Common side effects of Lipodox include:

The dosing and regimen of Lipodox depends on the condition being treated. Lipodox may interact with other anticancer therapies. Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plan to become pregnant before using Lipodox; it may harm a fetus. Because of the potential of serious adverse effects in nursing infants from Lipodox, breastfeeding should be discontinued prior to taking this drug.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

SLIDESHOW

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Lipodox Consumer Information

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Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Some side effects may occur during the injection. Tell your caregiver right away if you feel feverish, chilled, light-headed, short of breath, itchy, warm or tingly, or have a headache, pain or tightness in your chest or throat, back pain, fast heartbeats, swelling in your face, or blue-colored skin, lips, or nails.

Call your doctor at once if you have:

  • blisters or ulcers in your mouth, red or swollen gums, trouble swallowing;
  • hand-foot syndrome--pain, redness, numbness, and peeling skin on your hands or feet;
  • low blood cell counts--fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath; or
  • signs of heart problems--fast heartbeats, shortness of breath (even with mild exertion), feeling very weak or tired, swelling in your ankles or feet.

Doxorubicin liposomal may cause your urine to turn a reddish-orange color. This side effect is usually not harmful.

Common side effects may include:

  • low blood cell counts;
  • fever;
  • feeling weak or tired;
  • loss of appetite, nausea, vomiting;
  • constipation, diarrhea;
  • hand-foot syndrome;
  • rash; or
  • hair loss.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Lipodox (doxorubicin)

QUESTION

Where does ovarian cancer occur? See Answer
Lipodox Professional Information

SIDE EFFECTS

Ovarian Cancer Patients/Breast Cancer Patients

Adverse effects reported in 5% of patients include hematological adverse events such as leucopenia, neutropenia, anemia, thrombocytopenia and the non hematological adverse events such as palmar-plantar erythrodysesthesia (all grades), stomatitis (all grades), nausea (all grades), asthenia, vomiting, rash, alopecia, constipation, anorexia, mucous membrane disorder, diarrhea, abdominal pain, paresthesia, pain, fever, pharyngitis, dry skin, headache, dyspepsia, somnolence and skin discolouration.

The adverse effects reported in 1-5% of ovarian cancer patients are allergic reaction, chills, infection, chest pain, back pain, enlarged abdomen, malaise, oral moniliasis, mouth ulceration, esophagitis, dysphagia, peripheral edema, dehydration, myalgia, dizziness, depression, insomnia, anxiety, dyspnea, increased cough, rhinitis, pruritus, skin disorder, exfoliative dermatitis, herpes zoster, sweating, conjunctivitis and taste perversion.

The adverse effects reported in 1-5% of breast cancer patients are breast pain, leg cramps, edema, leg edema, peripheral neuropathy, oral pain, ventricular arrhythmia, folliculitis, bone pain, musculoskeletal pain, cold sores (non herpetic), fungal infection, epistaxis, upper respiratory tract infection, bullous eruption, dermatitis, erythematous rash, nail disorder, scaly skin, lacrimation and blurred vision.

AIDS-KS Patients

Adverse effects associated with the discontinuation of treatment are bone marrow suppression, cardiac adverse events, infusion related reactions, toxoplasmosis, palmar-plantar erythrodysesthesia, pneumonia, cough/dyspnea, fatigue, optic neuritis, progression of a non-KS tumour and allergy to penicillins.

Adverse reactions reported in ≥ 5% of patients include hematological side effects such as neutropenia, anemia, thrombocytopenia and non hematological side events such as nausea, asthenia, fever, alopecia, increased alkaline phosphatase, vomiting, hypochromic anemia, diarrhea, stomatitis and oral moniliasis.

Side effects reported in 1-5% of patients which may be possibly drug related are headache, back pain, infection, allergic reaction, chills, chest pain, hypotension, tachycardia, herpes simplex, rash, itching, mouth ulceration, glossitis, constipation, aphthous stomatitis, anorexia, dysphagia, abdominal pain, hemolysis, increased prothrombin time, increased SGPT, weight loss, hypocalcemia, hyperbilirubinemia, hyperglycemia, dyspnea, albuminuria, pneumonia, retinitis, emotional lability, dizziness and somnolence.

Read the entire FDA prescribing information for Lipodox (doxorubicin)

© Lipodox Patient Information is supplied by Cerner Multum, Inc. and Lipodox Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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