Liposyn III Side Effects Center

Last updated on RxList: 2/2/2009
Liposyn III Side Effects Center

Last reviewed on RxList 6/8/2016

Liposyn III (intravenous fat emulsion) is a source of calories and fat used to provide calories to patients who are getting their nutrition through an injection into the vein. Liposyn III is also used to provide essential fatty acids to people who do not have enough of it. Liposyn III is available in generic form. Common side effects of Liposyn III include:

  • headache
  • dizziness
  • flushing
  • drowsiness
  • nausea
  • vomiting
  • sweating
  • allergic reactions
  • shortness of breath
  • sleepiness
  • sweating
  • chest and back pain
  • overheating of the body, and
  • temporary increases in liver enzymes

Liposyn III can provide up to 60% of daily calories at a dose not to exceed 3 g/kg of body weight per day. Liposyn III may interact with other drugs. Tell your doctor all medications and supplements you use. During pregnancy, Liposyn III should be used only if prescribed. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

Our Liposyn III (intravenous fat emulsion) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


According to the USDA, there is no difference between a “portion” and a “serving.” See Answer
Liposyn III Consumer Information
SIDE EFFECTS: Headache, dizziness, flushing, drowsiness, nausea, vomiting, or sweating may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur: signs of infection (e.g., fever, persistent sore throat), pain/swelling/redness at injection site, pain/swelling/redness of arms/legs, bluish skin, sudden weight gain, shortness of breath, back/chest pain.

Tell your doctor immediately if any of these rare but very serious side effects occur: mental/mood changes, bone pain, muscle weakness, yellowing skin/eyes, dark urine, easy bruising/bleeding, severe stomach/abdominal pain, trouble breathing.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.


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Liposyn III Professional Information


Sepsis due to contamination of administration equipment and thrombophlebitis due to vein irritation from concurrently administered hypertonic solutions have been encountered. These are attributable to I.V. therapy in general or to the type of infusion administered.

Adverse reactions directly related to fat emulsions are of two types: (1) immediate (acute) and (2) long term (chronic). In studies of lipid products in general, the following immediate reactions have been noted: Allergic reactions, hyperlipemia, dyspnea, cyanosis, flushing, dizziness, headache, sleepiness, nausea, vomiting, hyperthermia, sweating, chest and back pain, thrombocytopenia (rarely in neonates), hypercoagulability and transient increases in liver enzymes.

The following reactions have been noted with long-term therapy with lipid infusions in general: Hepatomegaly, jaundice due to central lobular cholestasis, splenomegaly, thrombocytopenia, leucopenia, transient increases in liver function tests, overloading syndrome and the deposition of brown pigment ("fat pigment") in the reticuloendothelial tissue of the liver. The significance of this last occurrence and its cause are unknown.

Read the entire FDA prescribing information for Liposyn III (Intravenous Fat Emulsion)

© Liposyn III Patient Information is supplied by Cerner Multum, Inc. and Liposyn III Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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