Lo Ovral

Last updated on RxList: 5/21/2008
Lo Ovral Side Effects Center

Last reviewed on RxList 01/19/2017

Lo/Ovral-28 (norgestrel and ethinyl estradiol) Tablets is a combination of female hormones used as contraception to prevent pregnancy. Lo/Ovral-28 is available in generic form. Common side effects of Lo/Ovral-28 include:

  • nausea (especially when you first start taking Lo/Ovral-28),
  • vomiting,
  • headache,
  • stomach cramping,
  • bloating,
  • dizziness,
  • vaginal discomfort/irritation/itching,
  • increased vaginal fluids/discharge,
  • breast tenderness or enlargement,
  • nipple discharge,
  • freckles or darkening of facial skin,
  • increased hair growth,
  • loss of scalp hair,
  • changes in weight or appetite,
  • problems with contact lenses, or
  • decreased sex drive.

Acne may improve or get worse. Vaginal bleeding between menstrual periods (spotting) or missed/irregular periods may occur, especially during the first few months of use. Tell your doctor if you have serious side effects of Lo/Ovral-28 including:

  • sudden numbness or weakness, especially on one side of the body;
  • sudden and severe headache, confusion, problems with vision, speech, or balance;
  • chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
  • sudden cough, wheezing, rapid breathing, coughing up blood;
  • pain, swelling, warmth, or redness in one or both legs;
  • a change in the pattern or severity of migraine headaches;
  • upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • swelling in your hands, ankles, or feet;
  • a breast lump;
  • or symptoms of depression (sleep problems, weakness, tired feeling, mood changes).

Dose of Lo/Ovral is one tablet daily for twenty-one consecutive days, beginning on the first day (Day 1 Start) of the menstrual cycle or on the Sunday after the period begins (Sunday Start). The tablets are then discontinued for one week (7 days). Withdrawal bleeding usually occurs within 3 days following discontinuation of Lo/Ovral and may not finish before the next pack is started. Follow pack instructions. Lo/Ovral may interact with acetaminophen, ascorbic acid (vitamin C), modafinil, dexamethasone, antibiotics, seizure medicines, or HIV medicines. Tell your doctor all medications you use. Lo/Ovral must not be used during pregnancy. If you have just given birth or had a pregnancy loss/abortion after the first 3 months, talk with your doctor about birth control, and find out when it is safe to use birth control containing estrogen, such as this medication. This medication passes into breast milk. This may affect milk production and may have undesirable effects on a nursing infant. Consult your doctor before breastfeeding.

Our Lo/Ovral-28 (norgestrel and ethinyl estradiol) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

QUESTION

Which of the following are methods for contraception? See Answer
Lo Ovral Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have:

  • signs of a stroke--sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance;
  • signs of a blood clot--sudden vision loss, stabbing chest pain, feeling short of breath, coughing up blood, pain or warmth in one or both legs;
  • heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;
  • liver problems--loss of appetite, upper stomach pain, tiredness, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • increased blood pressure--severe headache, blurred vision, pounding in your neck or ears;
  • swelling in your hands, ankles, or feet;
  • a change in the pattern or severity of migraine headaches;
  • a breast lump; or
  • symptoms of depression--sleep problems, weakness, tired feeling, mood changes.

Common side effects may include:

  • nausea or vomiting (especially when you first start taking this medicine);
  • stomach pain, gas;
  • headache, nervousness;
  • breakthrough bleeding;
  • acne, darkening of facial skin;
  • changes in weight or appetite;
  • breast tenderness;
  • vaginal itching or discharge; or
  • menstrual cramps.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Lo Ovral (Norgestrel And Ethinyl Estradiol)

SLIDESHOW

Choosing Your Birth Control Method See Slideshow
Lo Ovral Professional Information

SIDE EFFECTS

An increased risk of the following serious adverse reactions (see WARNINGS section for additional information) has been associated with the use of oral contraceptives:

Thromboembolic and thrombotic disorders and other vascular problems (including thrombophlebitis and venous thrombosis with or without pulmonary embolism, mesenteric thrombosis, arterial thromboembolism, myocardial infarction, cerebral hemorrhage, cerebral thrombosis), carcinoma of the reproductive organs and breasts, hepatic neoplasia (including hepatic adenomas or benign liver tumors), ocular lesions (including retinal vascular thrombosis), gallbladder disease, carbohydrate and lipid effects, elevated blood pressure, and headache including migraine.

The following adverse reactions have been reported in patients receiving oral contraceptives and are believed to be drug related (alphabetically listed):

Acne
Amenorrhea
Anaphylactic/anaphylactoid reactions, including urticaria, angioedema, and severe reactions with
respiratory and circulatory symptoms
Breakthrough bleeding
Breast changes: tenderness, pain, enlargement, secretion
Budd-Chiari syndrome
Cervical erosion and secretion, change in
Cholestatic jaundice
Chorea, exacerbation of
Colitis
Corneal curvature (steepening), change in
Diminution in lactation when given immediately postpartum
Dizziness
Edema/fluid retention
Erythema multiforme
Erythema nodosum
Gastrointestinal symptoms (such as abdominal pain, cramps, and bloating)
Hirsutism
Intolerance to contact lenses
Libido, changes in
Loss of scalp hair
Melasma/chloasma which may persist
Menstrual flow, change in
Mood changes, including depression
Nausea
Nervousness
Pancreatitis
Porphyria, exacerbation of
Rash (allergic)
Serum folate levels, decrease in
Spotting
Systemic lupus erythematosus, exacerbation of
Temporary infertility after discontinuation of treatment
Vaginitis, including candidiasis
Varicose veins, aggravation of
Vomiting
Weight or appetite (increase or decrease), change in


The following adverse reactions have been reported in users of oral contraceptives:


Cataracts
Cystitis-like syndrome
Dysmenorrhea
Hemolytic uremic syndrome
Hemorrhagic eruption
Optic neuritis, which may lead to partial or complete loss of vision
Porphyria
Premenstrual syndrome
Renal function, impaired

Read the entire FDA prescribing information for Lo Ovral (Norgestrel And Ethinyl Estradiol)

© Lo Ovral Patient Information is supplied by Cerner Multum, Inc. and Lo Ovral Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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