Locoid Lipocream Side Effects Center

Last updated on RxList: 4/4/2022
Locoid Lipocream Side Effects Center

What Is Locoid Lipocream?

Locoid Lipocream (hydrocortisone butyrate) Cream, 0.1% is a topical (for the skin) steroid used to treat inflammation of the skin caused by a number of conditions such as allergic reactions, eczema, or psoriasis. Locoid Lipocream is available in generic form.

What Are Side Effects of Locoid Lipocream?

Common side effects of Locoid Lipocream include:

  • stinging,
  • burning,
  • itching,
  • irritation,
  • dryness,
  • redness, or
  • peeling at the application site when this medication is first applied to the skin

These side effects should disappear in a few days as your body adjusts to Locoid Lipocream. Other side effects of Locoid Lipocream include:

Tell your doctor if you have serious side effects Locoid Lipocream including:

  • blurred vision,
  • seeing halos around lights,
  • uneven heartbeats,
  • sleep problems (insomnia),
  • weight gain,
  • puffiness in your face, or
  • feeling tired.

Dosage for Locoid Lipocream

Apply a thin film dose of Locoid Lipocream to the affected skin areas two or three times daily, depending on the severity of the condition. Rub in gently.

What Drugs, Substances, or Supplements Interact with Locoid Lipocream?

Locoid Lipocream may interact with other drugs. Tell your doctor all medications and supplements you use.

Locoid Lipocream During Pregnancy or Breastfeeding

During pregnancy, Locoid Lipocream should be used only if prescribed. It is unknown if this drug passes into breast milk when applied to the skin. Similar medications pass into breast milk when taken by mouth. Consult your doctor before breastfeeding.

Additional Information

Our Locoid Lipocream (hydrocortisone butyrate) Cream, 0.1% Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Locoid Lipocream Consumer Information

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Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • worsening of your skin condition;
  • redness, warmth, swelling, oozing, or severe irritation of any treated skin;
  • high blood sugar--increased thirst, increased urination, dry mouth, fruity breath odor; or
  • possible signs of absorbing this medicine through your skin--weight gain (especially in your face or your upper back and torso), slow wound healing, thinning or discolored skin, increased body hair, muscle weakness, nausea, diarrhea, tiredness, mood changes, menstrual changes, sexual changes.

Less serious side effects may be more likely, and you may have none at all.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Locoid Lipocream Professional Information


The following adverse reactions are discussed in greater detail in other sections of the labeling:

  • HPA-axis suppression. This has been observed in pediatric subjects using Locoid Lipocream [see WARNINGS AND PRECAUTIONS and Use In Specific Populations]
  • Concomitant skin infections [see WARNINGS AND PRECAUTIONS]
  • Allergic contact dermatitis [see WARNINGS AND PRECAUTIONS]

Clinical Trials Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice.

The safety data derived from Locoid Lipocream clinical trials reflect exposure to Locoid Lipocream twice daily for up to 4 weeks in separate clinical trials involving pediatric subjects 3 months to 18 years of age with mild to moderate atopic dermatitis. Adverse reactions shown in the table below include those for which there is some basis to believe there is a causal relationship to Locoid Lipocream.

Table 1: Frequency of adverse reactions in pediatric subjects with mild to moderate atopic dermatitis

Locoid Lipocream
Application site reactions, including application site folliculitis, irritation, dermatitis, erythema 1.5% 1.5%
Acne 0.8% 0.0%
Telangiectasia 0.0% 0.8%

Postmarketing Experience

Because adverse reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

The following additional local adverse reactions have been reported infrequently with topical corticosteroids but may occur more frequently with the use of occlusive dressings. These reactions are listed in an approximate decreasing order of occurrence: burning, itching, drying, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infection, skin atrophy, striae, and miliaria.


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Read the entire FDA prescribing information for Locoid Lipocream (Hydrocortisone Butyrate)

© Locoid Lipocream Patient Information is supplied by Cerner Multum, Inc. and Locoid Lipocream Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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