Medical Editor: John P. Cunha, DO, FACOEP
Lodosyn (carbidopa) is an inhibitor of aromatic amino acid decarboxylation used with levodopa to treat the stiffness, tremors, spasms, and poor muscle control of Parkinson's disease. Lodosyn and levodopa are also used to treat the same muscular conditions when caused by drugs such as chlorpromazine, fluphenazine, perphenazine, and others. Levodopa is turned into dopamine in the body. Lodosyn (carbidopa) is used with levodopa to prevent the breakdown (metabolism) of levodopa before it can reach the brain and take effect. Side effects with Lodosyn are rare and usually occur due to the effect of levodopa or other drugs used along with this medication. Side effects of Lodosyn and levodopa may include:
- loss of appetite
- trouble sleeping (insomnia)
- unusual dreams or nightmares
- dry mouth
- blurred vision
- hand tremor
- muscle twitches
- darkening of urine
- sweat, or
Most patients respond to a 1:10 proportion of Lodosyn and levodopa, provided the daily dosage of Lodosyn is 70 mg or more a day. The maximum daily dosage of Lodosyn should not exceed 200 mg. Lododyn may interact with monoamine oxidase inhibitors (MAOIs), antacids, medicines to treat high blood pressure, medicines to treat seizures, papaverine, pyridoxine or vitamin B6, antidepressants, or medicines used to treat psychiatric conditions. Tell your doctor all medications and supplements you use. Lodosyn should be used only when prescribed during pregnancy. It is unknown if this medication passes into breast milk. Consult your doctor before breastfeeding.
Our Lodosyn (carbidopa) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Carbidopa alone is not associated with side effects. The following side effects are generally associated with carbidopa and levodopa therapy.
If you experience any of the following serious side effects, stop taking carbidopa and levodopa and seek emergency medical attention or contact your doctor immediately:
- an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
- uncontrolled movements of a part of the body;
- persistent nausea, vomiting, or diarrhea;
- an irregular heartbeat or fluttering in your chest;
- unusual changes in mood or behavior; or
- depression or suicidal thoughts.
Other, less serious side effects may be more likely to occur. Continue to take carbidopa and levodopa and talk to your doctor if you experience
- mild nausea, vomiting, or decreased appetite;
- constipation, dry mouth, or blurred vision;
- hand tremor;
- muscle twitches;
- dizziness or drowsiness;
- insomnia, confusion, or nightmares;
- agitation or anxiety;
- darkening of urine or sweat; or
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may report side effects to FDA at 1-800-FDA-1088.
Read the entire detailed patient monograph for Lodosyn (Carbidopa)
Carbidopa has not been demonstrated to have any overt pharmacodynamic actions in the recommended doses. The only adverse reactions that have been observed have been with concomitant use of carbidopa with other drugs such as levodopa, and with carbidopalevodopa combination products.
When LODOSYN is administered concomitantly with levodopa or carbidopa-levodopa combination products, the most common adverse reactions have included dyskinesias such as choreiform, dystonic, and other involuntary movements, and nausea. Other adverse reactions reported with LODOSYN when administered concomitantly with levodopa alone or carbidopa-levodopa combination products were psychotic episodes including delusions, hallucinations, and paranoid ideation, depression with or without development of suicidal tendencies, and dementia. Convulsions also have occurred; however, a causal relationship with concomitant use of LODOSYN and levodopa has not been established.
The following other adverse reactions have been reported with levodopa and carbidopalevodopa combination products. These same adverse reactions may also occur when LODOSYN is administered with these products.
Body as a Whole: abdominal pain and distress, asthenia, chest pain, fatigue.
Gastrointestinal: anorexia, bruxism, burning sensation of the tongue, constipation, dark saliva, development of duodenal ulcer, diarrhea, dry mouth, dyspepsia, dysphagia, flatulence, gastrointestinal bleeding, gastrointestinal pain, heartburn, hiccups, sialorrhea, taste alterations, vomiting.
Metabolic: edema, weight gain, weight loss.
Musculoskeletal: back pain, leg pain, muscle cramps, shoulder pain.
Nervous System/Psychiatric: Psychotic episodes including delusions, hallucinations and paranoid ideation, neuroleptic malignant syndrome (NMS, see WARNINGS), bradykinetic episodes (“on-off” phenomenon), confusion, agitation, dizziness, somnolence, dream abnormalities including nightmares, insomnia, paresthesia, headache, depression with or without development of suicidal tendencies, dementia, pathological gambling, increased libido including hypersexuality, impulse control symptoms. Convulsions also have occurred; however, a causal relationship with LODOSYN and levodopa, has not been established.
Special Senses: oculogyric crises, diplopia, blurred vision, dilated pupils.
Laboratory Tests: abnormalities in alkaline phosphatase, SGOT (AST), SGPT (ALT), lactic dehydrogenase, bilirubin, blood urea nitrogen (BUN), Coombs test; elevated serum glucose; decreased hemoglobin and hematocrit; decreased white blood cell count and serum potassium; increased serum creatinine and uric acid; white blood cells, bacteria and blood in the urine; protein and glucose in the urine.
Read the entire FDA prescribing information for Lodosyn (Carbidopa)
© Lodosyn Patient Information is supplied by Cerner Multum, Inc. and Lodosyn Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.