Lok Pak Side Effects Center

Last updated on RxList: 6/7/2022
Lok Pak Side Effects Center

What Is Lok Pak?

Lok Pak (heparin lock flush solution) is used only to maintain potency of an intravenous injection device. Lok Pak may be used following initial placement of the device in the vein, after each injection of a medication or after withdrawal of blood for laboratory analysis. The Lok Pak solution is not to be used for anticoagulation therapy. Lok Pak may be available in generic form.

What Are Side Effects of Lok Pak?

Side effects of Lok Pak are uncommon; consult your doctor.

Dosage for Lok Pak

Lok Pak Heparin Lock Flush Solution 10 or 100 USP Units/mL, is injected as a single dose into an intravenous injection device using a volume of solution equivalent to that of the indwelling venipuncture device.

What Drugs, Substances, or Supplements Interact with Lok Pak?

Lok Pak may interact with oral anticoagulants, acetylsalicylic acid, dextran, phenylbutazone, ibuprofen, indomethacin, dipyridamole, hydroxychloroquine, digitalis, tetracyclines, nicotine, antihistamines, or I.V. nitroglycerin. Tell your doctor all medications and supplements you use.

Lok Pak During Pregnancy or Breastfeeding

During pregnancy, Lok Pak Heparin Lock Flush Solution should be used only if prescribed. This drug does not pass into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our Lok Pak (heparin lock flush solution) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


About how much does an adult human brain weigh? See Answer
Lok Pak Consumer Information

Get emergency medical help if you have signs of an allergic reaction: nausea, vomiting, sweating, hives, itching, trouble breathing, swelling of your face, lips, tongue, or throat, or feeling like you might pass out.

Heparin flush can cause bleeding. Call your doctor at once if you have easy bruising or unusual bleeding, such as a nosebleed, black or bloody tarry stools, or any bleeding that will not stop.

Stop using heparin flush and call your doctor at once if you have:

  • signs of a stroke--sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance;
  • signs of a blood clot in the lung--chest pain, sudden cough, wheezing, rapid breathing, coughing up blood;
  • signs of a blood clot in your leg--pain, swelling, warmth, or redness in one or both legs;
  • a light-headed feeling, like you might pass out;
  • skin changes in your arms, legs, hands, or feet; or
  • (in an infant) extreme drowsiness, weakness, or gasping for breath.

Less serious side effects are more likely, and you may have none at all.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Lok Pak (Heparin Lock Flush Solution)


Digestive Disorders: Common Misconceptions See Slideshow
Lok Pak Professional Information



Hemorrhage is the chief complication that may result from heparin. An overly prolonged clotting time or minor bleeding during therapy can usually be controlled by withdrawing the drug (see OVERDOSAGE).


Generalized hypersensitivity reactions have been reported, with chills, fever, and urticaria as the most usual manifestations, and asthma, rhinitis, lacrimation, headache, nausea and vomiting, and anaphylactoid reactions, including shock, occurring more rarely. Itching and burning, especially on the plantar side of the feet, may occur.

Thrombocytopenia has been reported to occur in patients receiving heparin with a reported incidence of 0% to 30%. While often mild and of no obvious clinical significance, such thrombocytopenia can be accompanied by severe thromboembolic complications such as skin necrosis, gangrene of the extremities that may lead to amputation, myocardial infarction, pulmonary embolism, stroke, and possibly death. (See WARNINGS and PRECAUTIONS.)

Certain episodes of painful, ischemic, and cyanosed limbs have in the past been attributed to allergic vasospastic reactions. Whether these are in fact identical to the thrombocytopenia-associated complications remains to be determined.

Read the entire FDA prescribing information for Lok Pak (Heparin Lock Flush Solution)

© Lok Pak Patient Information is supplied by Cerner Multum, Inc. and Lok Pak Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

Health Solutions From Our Sponsors