Lomotil vs. Imodium

Are Lomotil and Imodium the Same Thing?

Lomotil (diphenoxylate and atropine) and Imodium (loperamide hydrochloride) are antidiarrheal medications used to treat diarrhea.

Lomotil also contains an anticholinergic.

Imodium is also used to reduce the amount of stool in people who have an ileostomy (re-routing of the bowel through a surgical opening in the stomach).

Imodium is available in generic form and over-the-counter (OTC).

What Are Possible Side Effects of Lomotil?

Common side effects of Lomotil include:

Tell your doctor if you experience unlikely but serious side effects of Lomotil including:

  • stomach or abdominal pain or swelling,
  • severe nausea or vomiting,
  • mental/mood changes (e.g., confusion, depression), or
  • numbness and tingling of arms or legs.

What Are Possible Side Effects of Imodium?

Common side effects of Imodium include:

Tell your doctor if you experience serious side effects of Imodium including

  • severe constipation/nausea/vomiting,
  • stomach or abdominal pain, or
  • uncomfortable fullness of the stomach or abdomen.

What Is Lomotil?

Lomotil (diphenoxylate and atropine) is a combination antidiarrheal medication, and an anticholinergic used to treat diarrhea.

What Is Imodium?

Imodium (loperamide hydrochloride) is an antidiarrheal used to treat diarrhea. Imodium is also used to reduce the amount of stool in people who have an ileostomy (re-routing of the bowel through a surgical opening in the stomach). Imodium is available in generic form and over-the-counter (OTC).

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What Drugs Interact With Lomotil?

Lomotil may interact with barbiturates or MAO inhibitors. Lomotil may interact with other drugs. Tell your doctor all prescription and over-the-counter medications and supplements you use.

What Drugs Interact With Imodium?

Imodium may interact with saquinavir (Invirase). Other drugs may interact with Imodium. Tell your doctor all prescription and over-the-counter medications and supplements you use.

How Should Lomotil Be Taken?

The recommended initial adult dosage is two Lomotil tablets four times daily or 10 ml (two regular tsp) of Lomotil liquid four times daily (20 mg per day). The pediatric dose is determined by the child's weight.

How Should Imodium Be Taken?

The recommended initial adult dose of Imodium is 4mg (two capsules) followed by 2 mg (one capsule) after each unformed stool. Daily dose should not exceed 16mg (eight capsules). In children 2 to 5 years of age (20 kg or less), the non-prescription liquid formulation Imodium A-D Liquid 1 mg/5 mL should be used; for ages 6 to 12, either capsules or A-D Liquid may be used.

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References

DailyMed. Lomotil Drug Information.
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f170584a-1072-4fd7-b1dc-6756703483b9
Johnson & Johnson Consumer Inc.. Imodium Product Information.
https://www.imodium.com

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