Lomotil vs. Viberzi

Are Lomotil and Viberzi the Same Thing?

Lomotil (diphenoxylate and atropine) and Viberzi (eluxadoline) are used treat diarrhea.

Viberzi is specifically used in adults to treat diarrhea associated with irritable bowel syndrome with diarrhea (IBS-D).

Viberzi and Lomotil belong to different drug classes. Viberzi is a mu-opioid receptor agonist and Lomotil is a combination antidiarrheal medication, and an anticholinergic.

What Are Possible Side Effects of Lomotil?

Common side effects of Lomotil include:

Tell your doctor if you experience unlikely but serious side effects of Lomotil including:

  • stomach or abdominal pain or swelling,
  • severe nausea or vomiting,
  • mental/mood changes (e.g., confusion, depression), or
  • numbness and tingling of arms or legs.

What Are Possible Side Effects of Viberzi?

Common side effects of Viberzi include:

What Is Lomotil?

Lomotil (diphenoxylate and atropine) is a combination antidiarrheal medication, and an anticholinergic used to treat diarrhea.

What Is Viberzi?

Viberzi (eluxadoline) is a mu-opioid receptor agonist used in adults to treat irritable bowel syndrome with diarrhea (IBS-D).


What is irritable bowel syndrome or IBS? See Answer

What Drugs Interact With Lomotil?

Lomotil may interact with barbiturates or MAO inhibitors. Lomotil may interact with other drugs. Tell your doctor all prescription and over-the-counter medications and supplements you use.

What Drugs Interact With Viberzi?

Viberzi may interact with other irritable bowel medications, narcotic pain medicines, or heart rhythm medications.

Viberzi may also interact with cyclosporine, gemfibrozil, antiretrovirals, rifampin, eltrombopag, ciprofloxacin, fluconazole, clarithromycin, paroxetine, bupropion, anticholinergics, opioids, rosuvastatin, dihydroergotamine, ergotamine, pimozide, sirolimus, or tacrolimus.

How Should Lomotil Be Taken?

The recommended initial adult dosage is two Lomotil tablets four times daily or 10 ml (two regular tsp) of Lomotil liquid four times daily (20 mg per day). The pediatric dose is determined by the child's weight.

How Should Viberzi Be Taken?

The recommended dosage of Viberzi in adults is 100 mg twice daily, taken with food.


Digestive Disorders: Common Misconceptions See Slideshow

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DailyMed. Lomotil Drug Information.
Allergan. Viberzi Product Information.

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