Slideshows Images Quizzes

Copyright © 2018 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. See additional information.


Last reviewed on RxList: 1/13/2021
Lopid Side Effects Center

What Is Lopid?

Lopid (gemfibrozil) is a lipid regulating agent used to treat very high cholesterol and triglyceride levels in people with pancreatitis, and is also used to lower the risk of stroke, heart attack, or other heart complications in people with high cholesterol and triglycerides who have not been helped by other treatments. Lopid is available in generic form.

What Are Side Effects of Lopid?

Common side effects of Lopid include:

Lopid may infrequently cause gallstones and liver problems.

Tell your doctor if you notice any of the following unlikely, but serious side effects of Lopid including:

  • severe stomach/abdominal pain,
  • persistent nausea or vomiting,
  • yellowing eyes or skin, and
  • dark urine.

Dosage for Lopid

The recommended dose of Lopid for adults is 1200 mg administered in two divided doses 30 minutes before the morning and evening meals.

What Drugs, Substances, or Supplements Interact with Lopid?

Lopid may interact with blood thinners, insulin or oral diabetes medication, or other cholesterol-lowering drugs. Tell your doctor all medications you use.

Lopid During Pregnancy and Breastfeeding

Lopid is not recommended for use during pregnancy. It is unknown if this medication passes into breast milk. Because of the possible risk to the infant, breastfeeding while using this drug is not recommended.

Additional Information

Our Lopid (gemfibrozil) Tablets Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


What is cholesterol? See Answer
Lopid Consumer Information

3 pharmacies near 20147 have coupons for Lopid (Brand Names:Lopid for 600MG)

CVS Pharmacy
CVS Pharmacy

Est. Regular Price


with free coupon

View Coupon

Est. Regular Price


with free coupon

View Coupon
Harris Teeter Pharmacy
Harris Teeter Pharmacy

Est. Regular Price


with free coupon

View Coupon

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

In rare cases, gemfibrozil can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.

Also call your doctor at once if you have:

  • sharp pain in your upper stomach (especially after eating);
  • jaundice (yellowing of your skin or eyes);
  • pain or burning when you urinate;
  • blurred vision, eye pain, or seeing halos around lights; or
  • pale skin, easy bruising, unusual bleeding, feeling light-headed or short of breath, rapid heart rate, purple or red pinpoint spots under your skin.

Common side effects may include:

  • stomach pain, indigestion, diarrhea;
  • numbness or tingly feeling;
  • dizziness, drowsiness;
  • blurred vision;
  • muscle or joint pain; or
  • loss of interest in sex, impotence.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Lopid (Gemfibrozil)


How to Lower Your Cholesterol & Save Your Heart See Slideshow
Lopid Professional Information


In the double-blind controlled phase of the primary prevention component of the Helsinki Heart Study, 2046 patients received LOPID for up to five years. In that study, the following adverse reactions were statistically more frequent in subjects in the LOPID group:

(N = 2046)
(N = 2035)
Frequency in percent of subjects
Gastrointestinal reactions 34.2 23.8
Dyspepsia 19.6 11.9
Abdominal pain 9.8 5.6
Acute appendicitis (histologically confirmed in most cases where data were available) 1.2 0.6
Atrial fibrillation      0.7  0.1
Adverse events reported by more than 1% of subjects, but without a significant difference between groups:
Diarrhea 7.2 6.5
Fatigue 3.8 3.5
Nausea/Vomiting 2.5 2.1
Eczema 1.9 1.2
Rash 1.7 1.3
Vertigo 1.5 1.3
Constipation 1.4 1.3
Headache 1.2 1.1

Gallbladder surgery was performed in 0.9% of LOPID and 0.5% of placebo subjects in the primary prevention component, a 64% excess, which is not statistically different from the excess of gallbladder surgery observed in the clofibrate group compared to the placebo group of the WHO study. Gallbladder surgery was also performed more frequently in the LOPID group compared to the placebo group (1.9% versus 0.3%, p=0.07) in the secondary prevention component. A statistically significant increase in appendectomy in the gemfibrozil group was seen also in the secondary prevention component (6 on gemfibrozil versus 0 on placebo, p=0.014).

Nervous system and special senses adverse reactions were more common in the LOPID group. These included hypesthesia, paresthesias, and taste perversion. Other adverse reactions that were more common among LOPID treatment group subjects but where a causal relationship was not established include cataracts, peripheral vascular disease, and intracerebral hemorrhage.

From other studies it seems probable that LOPID is causally related to the occurrence of MUSCULOSKELETAL SYMPTOMS (see WARNINGS), and to ABNORMAL LIVER FUNCTION TESTS and HEMATOLOGIC CHANGES (see PRECAUTIONS).

Reports of viral and bacterial infections (common cold, cough, urinary tract infections) were more common in gemfibrozil treated patients in other controlled clinical trials of 805 patients. Additional adverse reactions that have been reported for gemfibrozil are listed below by system. These are categorized according to whether a causal relationship to treatment with LOPID is probable or not established:

General:   weight loss
Cardiac:   extrasystoles pancreatitis
Gastrointestinal: cholestatic jaundice hepatoma colitis
Central Nervous    
System: dizziness somnolence paresthesia peripheral neuritis decreased libido depression headache confusion convulsions syncope
Eye: blurred vision retinal edema decreased male fertility
Genitourinary: impotence renal dysfunction
Musculoskeletal: myopathy myasthenia myalgia painful extremities arthralgia s yno vitis rhabdomyolysis (see WARNINGS and DRUG INTERACTIONS under PRECAUTIONS)  
Clinical increased creatine phosphokinase increased bilirubin  
Laboratory: increased liver transaminases (AST, ALT) increased alkaline phosphatase anemia positive antinuclear antibody
Hematopoietic: leukopenia bone marrow hypoplasia eosinophilia angioedema thrombocytopenia anaphylaxis
Immunologic: laryngeal edema urticaria exfoliative dermatitis Lupus-like syndrome vasculitis
Integumentary: rash dermatitis pruritus alopecia photosensitivity

Additional adverse reactions that have been reported include cholecystitis and cholelithiasis (see WARNINGS).

Read the entire FDA prescribing information for Lopid (Gemfibrozil)

Related Resources for Lopid

Read the Lopid User Reviews »

© Lopid Patient Information is supplied by Cerner Multum, Inc. and Lopid Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.


What is cholesterol? See Answer

Health Solutions From Our Sponsors