Medical Editor: John P. Cunha, DO, FACOEP
What Is Lopressor HCT?
Lopressor HCT (metoprolol tartrate and hydochlorothiazide) is a combination of a beta-blocker and thiazide diuretic (water pill) used to treat high blood pressure (hypertension). Lopressor HCT is available in generic form.
What Are Side Effects of Lopressor HCT?
Common side effects of Lopressor HCT include:
- dizziness,
- lightheadedness,
- spinning sensation,
- drowsiness,
- headache,
- slow heartbeat,
- tiredness,
- diarrhea,
- constipation,
- upset stomach,
- sore throat,
- body aches,
- blurred vision, or
- ringing in your ears
Seek medical care or call 911 at once if you have the following serious side effects:
- Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
- Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheartedness, or passing out;
- Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.
This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.
Dosage for Lopressor HCT?
The usual initial dosage of Lopressor is 100 mg daily in single or divided doses. The effective dosage range is 100 to 450 mg per day.
What Drugs, Substances, or Supplements Interact with Lopressor HCT?
Lopressor HCT may interact with insulin or oral diabetes medicines, colestipol, cholestyramine, theophylline, steroids, HIV or AIDS medicines, antidepressants, antibiotics, anti-malaria medication, medicine to treat psychiatric or mood disorders, aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs), or other heart or blood pressure medications. Tell your doctor all medications you use.
Lopressor HCT During Pregnancy and Breastfeeding
During pregnancy, Lopressor HCT should be used only when prescribed. It may harm a fetus. Metoprolol and hydrochlorothiazide pass into breast milk, but are unlikely to harm a nursing infant. Consult your doctor before breastfeeding.
Additional Information
Our Lopressor HCT (metoprolol tartrate and hydochlorothiazide) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
QUESTION
Salt and sodium are the same. See AnswerGet emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
- bronchospasm (wheezing, chest tightness, trouble breathing);
- slow heart rate, weak pulse, fainting, slow breathing (breathing may stop);
- blurred vision, tunnel vision, eye pain, or seeing halos around lights;
- low potassium level--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling; or
- low sodium level --headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady.
Common side effects may include:
- tired feeling; or
- stuffy nose, sore throat.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
SLIDESHOW
How to Lower Blood Pressure: Exercise Tips See SlideshowSIDE EFFECTS
Lopressor HCT (metoprolol tartrate and hydochlorothiazide)
The following adverse reactions were reported in controlled clinical studies of the combination of Lopressor and hydrochlorothiazide.
Body as a Whole: Fatigue or lethargy and flu syndrome have each been reported in about 10 in 100 patients.
Nervous System: Dizziness or vertigo, drowsiness or somnolence, and headache have each occurred in about 10 in 100 patients. Nightmare has occurred in 1 in 100 patients.
Cardiovascular: Bradycardia has occurred in about 6 in 100 patients. Decreased exercise tolerance and dyspnea have each occurred in about 1 of 100 patients.
Digestive: Diarrhea, digestive disorder, dry mouth, nausea or vomiting, and constipation have each occurred in about 1 in 100 patients.
Metabolic and Nutritional: Hypokalemia has occurred in fewer than 10 in 100 patients. Edema, gout, and anorexia have each occurred in 1 in 100 patients.
Special Senses: Blurred vision, tinnitus, and earache have each been reported in 1 in 100 patients.
Skin: Sweating and purpura have each occurred in 1 in 100 patients.
Urogenital: Impotence has occurred in 1 in 100 patients.
Musculoskeletal: Muscle pain has occurred in 1 in 100 patients.
Lopressor
Most adverse effects have been mild and transient.
Central Nervous System: Tiredness and dizziness have occurred in about 10 of 100 patients. Depression has been reported in about 5 of 100 patients. Mental confusion and short-term memory loss have been reported. Headache, nightmares, and insomnia have also been reported, but a drug relationship is not clear.
Cardiovascular: Shortness of breath and bradycardia have occurred in approximately 3 of 100 patients. Cold extremities; arterial insufficiency, usually of the Raynaud type; palpitations; and congestive heart failure have been reported. Gangrene in patients with pre-existing severe peripheral circulatory disorders has also been reported very rarely (see CONTRAINDICATIONS, WARNINGS, and PRECAUTIONS).
Respiratory: Wheezing (bronchospasm) has been reported in fewer than 1 of 100 patients (see WARNINGS). Rhinitis has also been reported.
Gastrointestinal: Diarrhea has occurred in about 5 of 100 patients. Nausea, gastric pain, constipation, flatulence, and heartburn have been reported in 1 of 100, or fewer, patients. Vomiting was a common occurrence. Postmarketing experience reveals very rare reports of hepatitis, jaundice and non-specific hepatic dysfunction. Isolated cases of transaminase, alkaline phosphatase, and lactic dehydrogenase elevations have also been reported.
Hypersensitive Reactions: Pruritus has occurred in fewer than 1 of 100 patients. Rash has been reported. Very rarely, photosensitivity and worsening of psoriasis has been reported.
Miscellaneous: Peyronie's disease has been reported in fewer than 1 of 100,000 patients. Alopecia has been reported. There have been very rare reports of weight gain, arthritis, and retroperitoneal fibrosis (relationship to Lopressor has not been definitely established).
The oculomucocutaneous syndrome associated with the beta blocker practolol has not been reported with Lopressor.
Potential Adverse Reactions
A variety of adverse reactions not listed above have been reported with other beta-adrenergic blocking agents and should be considered potential adverse reactions to Lopressor.
Central Nervous System: Reversible mental depression progressing to catatonia; visual disturbances; hallucinations; an acute reversible syndrome characterized by disorientation for time and place, short-term memory loss, emotional lability, slightly clouded sensorium, and decreased performance on neuropsychometrics.
Cardiovascular: Intensification of AV block (see CONTRAINDICATIONS).
Hematologic: Agranulocytosis, nonthrombocytopenic purpura, thrombocytopenic purpura.
Hypersensitive Reactions: Fever combined with aching and sore throat, laryngospasm, and respiratory distress.
Postmarketing Experience
The following adverse reactions have been reported during postapproval use of Lopressor: confusional state, an increase in blood triglycerides and a decrease in High Density Lipoprotein (HDL). Because these reports are from a population of uncertain size and are subject to confounding factors, it is not possible to reliably estimate their frequency.
Hydrochlorothiazide
The following adverse reactions have been observed, but there has not been enough systematic collection of data to support an estimate of their frequency. Consequently the reactions are categorized by organ systems and are listed in decreasing order of severity and not frequency.
Digestive: Pancreatitis, jaundice (intrahepatic cholestatic), sialadenitis, vomiting, diarrhea, cramping, nausea, gastric irritation, constipation, anorexia.
Cardiovascular: Orthostatic hypotension (may be potentiated by alcohol, barbiturates, or narcotics).
Neurologic: Vertigo, dizziness, transient blurred vision, headache, paresthesia, xanthopsia, weakness, restlessness.
Musculoskeletal: Muscle spasm.
Hematologic: Aplastic anemia, agranulocytosis, leukopenia, thrombocytopenia. Metabolic: Hyperglycemia, glycosuria, hyperuricemia.
Hypersensitive Reactions: Necrotizing angiitis, Stevens-Johnson syndrome, respiratory distress including pneumonitis and pulmonary edema, purpura, urticaria, rash, photosensitivity.
Read the entire FDA prescribing information for Lopressor HCT (Metoprolol Tartrate and Hydochlorothiazide)
© Lopressor HCT Patient Information is supplied by Cerner Multum, Inc. and Lopressor HCT Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.
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